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Vaccination: Hepatitis Vaccine

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Total 4934 results found since Jan 2013.

The Possible Protective Effect of Hepatitis B Vaccine Against Lymphomas: A Systematic Review
CONCLUSION: Although the literature is still largely lacking regarding the protective effect of anti-HBV vaccination on lymphoma subtypes, the association between HBV infection and lymphoma has been confirmed in several studies. Vaccination programs eliminate the risk of HBV infection and prevent liver disease but can also indirectly reduce the risk of lymphomas.PMID:35049430 | DOI:10.2174/1389201023666220113111946
Source: Current Pharmaceutical Biotechnology - January 20, 2022 Category: Biotechnology Authors: Lorenza Lia Daniela Grima Francesca Amici Linda Manzi Alessandro Monaci Giuseppe La Torre Source Type: research

PreHevbrio: A New 3-Antigen Hepatitis B Vaccine for Adults
CONCLUSIONS: The 3A-HepB represents another vaccine to prevent hepatitis B in adults. It is safe and immunogenic but is associated with more adverse reactions than 1A-HepB.PMID:35906803 | DOI:10.1177/10600280221114469
Source: The Annals of Pharmacotherapy - July 30, 2022 Category: Drugs & Pharmacology Authors: Allana J Sucher Brandon J Sucher Elias B Chahine Source Type: research

Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition.
CONCLUSIONS: Gianotti-Crosti syndrome is mainly a disease of early childhood, characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution. With the advent of more universal vaccination against hepatitis B virus, Epstein-Barr virus has become the most common etiologic agent of Gianotti-Crosti syndrome. Few cases of post-vaccination Gianotti-Crosti syndrome have been reported. Currently, the emphasis should be placed on its self-limiting attribution. PMID: 31134587 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - May 26, 2019 Category: Pediatrics Authors: Leung AKC, Sergi CM, Lam JM, Leong KF Tags: World J Pediatr Source Type: research

Efficient replication of blood borne Hepatitis C Virus in human fetal liver stem cells
Conclusion: Our data showed that the entire bbHCV life cycle could be naturally imitated in hFLSCs. This model is expected to provide a powerful tool for exploring the process and the mechanism of bbHCV infection at the cellular level, and evaluating the treatment and preventive strategies of bbHCV infection. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 13, 2017 Category: Internal Medicine Authors: Xuan Guo, Shu Wang, Zhi ‐Gang Qiu, Ya‐Ling Dou, Wei‐Li Liu, Dong Yang, Zhi‐Qiang Shen, Zhao‐Li Chen, Jing‐Feng Wang, Bin‐ Zhang, Xin‐Wei Wang, Xiang‐Fei Guo, Xue‐Lian Zhang, Min Jin, Jun‐Wen Li Tags: Viral Hepatitis Source Type: research

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination
Publication date: June 2018Source: Current Opinion in Virology, Volume 30Author(s): Claudia Dembek, Ulrike Protzer, Michael RoggendorfThe currently used nucleoside analogs (i.e. entecavir and tenofovir) with high barrier-to-resistance efficiently suppress viral replication, limit inflammation and reduce the sequelae of chronic hepatitis B, but cannot cure the disease and thus have to be applied long-term. Therapeutic vaccination as an approach to cure chronic hepatitis B has shown promising pre-clinical results, nevertheless the proof of its efficacy in clinical trials is still missing. This may be partially due to subopti...
Source: Current Opinion in Virology - July 5, 2018 Category: Virology Source Type: research

5′-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected mice
Publication date: Available online 15 November 2018Source: Antiviral ResearchAuthor(s): Qiuju Han, Zhaohua Hou, Chunlai Yin, Cai Zhang, Jian ZhangAbstractRNA with 5′-triphosphate (3p-RNA) is recognized by RNA sensor RIG-I (retinoic acid–inducible gene I protein). Previously, we reported that small interfering RNA targeting HBx (3p-siHBx) could confer potent anti–hepatitis B virus (HBV) efficacy via HBx silencing and RIG-I activation. However, the characteristics of innate and adaptive immunity especially exhaustion profiles in the liver microenvironment in response to 3p-siHBx therapy have not been fully elucidated. ...
Source: Antiviral Therapy - November 16, 2018 Category: Virology Source Type: research

Toward a Functional Cure for Hepatitis B: The Rationale and Challenges for Therapeutic Targeting of the B Cell Immune Response
The central role of the cellular immune response in the control and clearance of the hepatitis B virus (HBV) infection has been well-established. The contribution of humoral immunity, including B cell and antibody responses against HBV, has been investigated for a long time but has attracted increasing attention again in recent years. The anti-HBs antibody was first recognized as a marker of protective immunity after the acute resolution of the HBV infection (or vaccination) and is now defined as a biomarker for the functional cure of chronic hepatitis B (CHB). In this way, therapies targeting HBV-specific B cells and the ...
Source: Frontiers in Immunology - September 23, 2019 Category: Allergy & Immunology Source Type: research

A Novel Flavivirus-based System For Production Of Hepatitis C Virus (HCV): Production Of Infectious Virions And Development Of A Novel Reporter System For Studying HCV Virion Entry.
A Novel System for Producing Infectious Hepatitis C Virus (HCV) Virions and Development of a Novel Reporter System for Studying HCV EntryDescription of Technology: HCV has infected an estimated 3% of the world population in whom viral infection persists for more than two third of the cases, often resulting in life-threatening complications. The standard of care (pegylated interferon alpha-2 plus ribavirin) is efficient in only 50% of treated patients, costly and has numerous side effects. In addition, viral resistance to newly developed drugs -- targeting viral protease or RNA polymerase -- has been described, but no vacci...
Source: NIH OTT Licensing Opportunities - June 23, 2009 Category: Research Authors: ott-admin Source Type: research

A Novel System for Producing Infectious Hepatitis C Virus (HCV) Virions and Development of a Novel Reporter System for Studying HCV Entry
HCV has infected an estimated 3% of the world population in whom viral infection persists for more than two third of the cases, often resulting in life-threatening complications. The standard of care (pegylated interferon alpha-2 plus ribavirin) is efficient in only 50% of treated patients, costly and has numerous side effects. In addition, viral resistance to newly developed drugs -- targeting viral protease or RNA polymerase -- has been described, but no vaccine is yet available. The difficulty in developing HCV vaccines is largely due to the broad sequence-diversity displayed by HCV, the frequent occurrence of viral mut...
Source: NIH OTT Licensing Opportunities - June 23, 2009 Category: Research Authors: ott-admin Source Type: research

Viruses, Vol. 14, Pages 657: HBsAg Loss as a Treatment Endpoint for Chronic HBV Infection: HBV Cure
ung Despite the availability of effective vaccines and antiviral therapy over the past two to three decades, chronic hepatitis B virus (HBV) infection remains a major global health threat as a leading cause of cirrhosis and liver cancer. Functional HBV cure defined as hepatitis B surface antigen (HBsAg) loss and undetectable serum HBV DNA is associated with improved clinical outcomes in patients with chronic HBV infection. However, spontaneous loss of HBsAg is rare and occurs in only 1% of all HBsAg-positive individuals annually. Furthermore, the rate of functional cure with currently available antiviral therapy is eve...
Source: Viruses - March 22, 2022 Category: Virology Authors: Maryam Moini Scott Fung Tags: Review Source Type: research

Adult Vaccination as a Protective Factor for Dementia: A Meta-Analysis and Systematic Review of Population-Based Observational Studies
CONCLUSION: Routine adult vaccinations are associated with a significant reduction in dementia risk and may be an effective strategy for dementia prevention. Further research is needed to elucidate the causal effects of this association and the underlying mechanisms.PMID:35592323 | PMC:PMC9110786 | DOI:10.3389/fimmu.2022.872542
Source: Herpes - May 20, 2022 Category: Infectious Diseases Authors: Xinhui Wu Haixia Yang Sixian He Ting Xia Diang Chen Yexin Zhou Jin Liu MengSi Liu Zhen Sun Source Type: research