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Vaccination: Influenza Vaccine

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Total 427 results found since Jan 2013.

Vaccinations: More than just kid stuff
Follow me on Twitter @RobShmerling This is the time of year when it’s important to think about flu vaccinations. And there’s good reason for that! The flu causes thousands of preventable hospitalizations and deaths each year. But what about other vaccinations? Do you think of them as something for kids? You aren’t alone. And it’s true, a number of vaccinations are recommended for young children as well as preteens and teenagers. These vaccinations have provided an enormous benefit to public health by preventing diseases that were common and sometimes deadly in the past, including polio, rubella, and whooping cough....
Source: Harvard Health Blog - February 7, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Infectious diseases Prevention Vaccines Source Type: blogs

"I wouldn't really believe statistics" - Challenges with influenza vaccine acceptance among healthcare workers in Singapore.
CONCLUSION: Our findings highlight a combination of misperceptions about influenza vaccination and cognitive biases at the individual level, and challenges at the institutional level limiting uptake. Findings indicate an urgent need to provide targeted education and communication. Rather than providing more data, we recommend a widely-disseminated, locally-compiled synthesis addressing specific concerns of hesitant HCWs. Tailoring interventions to specific vocational groups should be considered. Institutional norms and culture may have a powerful influence in setting default behaviours: more effort is needed in improving i...
Source: Vaccine - March 5, 2018 Category: Allergy & Immunology Authors: Sundaram N, Duckett K, Yung CF, Thoon KC, Sidharta S, Venkatachalam I, Chow A, Yoong J Tags: Vaccine Source Type: research

Intranasal Nebulizer with Disposable Drug Cartridge for Improved Delivery of Vaccines and Therapeutics
Intranasal delivery is a simple, inexpensive and needle-free route for administration of vaccines and therapeutics. This intranasal delivery technology, developed with Creare LLC., includes low-cost, disposable drug cartridges (DDCs) that mate with a durable hand-held device. The rechargeable-battery-powered device transmits ultrasonic energy to the DDC to aerosolize the drug and is capable of performing for eight hours at 120 vaccinations per hour. Potential applications for this platform technology include intranasal vaccination (e.g. seasonal or pandemic influenza vaccines) and intranasal delivery of locally active (e.g...
Source: NIH OTT Licensing Opportunities - November 19, 2013 Category: Research Authors: ajoyprabhu3 Source Type: research

Sudden death from acute epiglottitis in a toddler
AbstractThe bacteriumHaemophilus influenzae type b (Hib) can cause severe and life-threatening infections such as epiglottitis and meningitis. The course of the disease can be very rapid, resulting in sudden death. The incidence of Hib-induced epiglottitis in children has declined since the introduction of vaccinations in countries where such vaccinations are routinely administered. We herein present a case involving a 2.5-year-old boy who died suddenly at home. He had developed acute-onset throat and abdominal pain and a high fever. Despite an emergency cricothyrotomy due to a complicated intubation because of a massively...
Source: Forensic Science, Medicine, and Pathology - June 20, 2018 Category: Forensic Medicine Source Type: research

Prospective cohort studies to evaluate the safety and immunogenicity of the 2013, 2014, and 2015 seasonal influenza vaccines produced by Instituto Butantan.
Abstract Annual vaccination is the most effective way to prevent seasonal influenza illness. Instituto Butantan (IB) performed clinical studies with its 2013, 2014 and 2015 seasonal trivalent influenza vaccines (inactivated split-virion). Prospective cohort studies were carried out to describe the safety and immunogenicity of Instituto Butantan influenza vaccines, in healthy adults and elderly, from 2013 to 2015. Immediately after the informed consent was signed, participants underwent blood collection followed by vaccination. On study days 1, 2 and 3 post-vaccination participants were contacted by the staff to ev...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - July 30, 2018 Category: Tropical Medicine Authors: Mondini G, Braga PE, Lopes MH, Sartori AMC, Miyaji KT, Infante V, Randi BA, Timenetsky MDCST, Ferreira JCOA, Sakita NK, Precioso AR Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Immunogenicity and safety of MF59-adjuvanted and full-dose unadjuvanted trivalent inactivated influenza vaccines among vaccine-na ïve children in a randomized clinical trial in rural Senegal.
CONCLUSIONS: Both aTIV and full-dose TIV were well-tolerated and immunogenic in children aged 6-71 months. These vaccines may play a role in programmatically suitable strategies to prevent influenza in low-resource settings. PMID: 30224199 [PubMed - as supplied by publisher]
Source: Vaccine - September 14, 2018 Category: Allergy & Immunology Authors: Diallo A, Victor JC, Feser J, Ortiz JR, Kanesa-Thasan N, Ndiaye M, Diarra B, Cheikh S, Diene D, Ndiaye T, Ndiaye A, Lafond KE, Widdowson MA, Neuzil KM Tags: Vaccine Source Type: research

Yes, You Should Get a Flu Shot in 2018. Here ’s Everything to Know
The 2017-2018 flu season was a bad one. The dominant viral strain, H3N2, was a particularly severe form of influenza, leading to widespread and serious illness across the country. The flu and its complications killed around 80,000 people last year, the CDC estimates, including 180 children. That’s the highest flu death toll in four decades. Experts say early indications suggest that this year’s flu season will be milder, but the memory of last winter should still serve as motivation to get the flu shot this fall. Here’s what you need to know about the 2018 flu shot. When should I get the flu shot? The CD...
Source: TIME: Health - October 5, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime public health Source Type: news

A phase III, open-label, single-arm, study to evaluate the safety and immunogenicity of a trivalent, surface antigen inactivated subunit influenza virus vaccine produced in mammalian cell culture (Optaflu ®) in healthy adults
AbstractVaccination is an essential tool in reducing the impact of seasonal influenza infections. The viral strains responsible for seasonal outbreaks vary annually, and preventive vaccines have to be adapted accordingly. The aim of this study was to evaluate the safety, clinical tolerability and the antibody response to each of the three influenza vaccine antigens after vaccination with a cell-derived, trivalent, surface antigen, inactivated influenza vaccine (TIVc), as measured by single radial haemolysis (SRH) or haemagglutination inhibition (HI) assay in accordance with European Union licensing guidelines in place for ...
Source: Infection - October 8, 2018 Category: Infectious Diseases Source Type: research

A 19-year old man with IgA vasculitis after vaccination
Publication date: Available online 30 October 2018Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Alexandre Malek, Sara Isabel Gomez-Villegas, Alejandro de la Hoz, Cima Nowbakht, Cesar A. AriasAbstractA 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72 h later. The diagnosis of influenza vaccine-related Henoch–Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis ...
Source: The Brazilian Journal of Infectious Diseases - October 31, 2018 Category: Infectious Diseases Source Type: research

A 19-year old man with IgA vasculitis after vaccination.
Abstract A 19-year-old patient who mistakenly received two doses of influenza vaccine 10 days before presentation, was admitted with malaise, weakness, and a purpuric non-blanching rash most prominent on the ankles followed by abdominal pain and hematochezia 72h later. The diagnosis of influenza vaccine-related Henoch-Schonlein vasculitis was made. This complication, although rare, is the most common vasculitis related to immunization. PMID: 30389353 [PubMed - as supplied by publisher]
Source: Braz J Infect Dis - October 30, 2018 Category: Infectious Diseases Authors: Malek A, Gomez-Villegas SI, de la Hoz A, Nowbakht C, Arias CA Tags: Braz J Infect Dis Source Type: research

Late Breaking Abstract - Safety and immunogenicity of non-typeable H. influenzae (NTHi) and M. catarrhalis (Mcat) adjuvanted vaccines in adults
Conclusion: NTHi-Mcat vaccines have an acceptable reactogenicity/safety profile and are immunogenic.Funding: GlaxoSmithKline Biologicals SA
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Van Damme, P., Leroux-Roels, G., Vandermeulen, C., De Ryck, I., Tasciotti, A., Dozot, M., Moraschini, L., Testa, M., Arora, A. K. Tags: Clinical Problems Source Type: research

Late Breaking Abstract - Safety and immunogenicity of non-typeable H. influenzae (NTHi) adjuvanted vaccine in older adults with chronic obstructive pulmonary disease (COPD)
Conclusion: NTHi vaccine has an acceptable safety profile, induces substantial increases in humoral responses and moderate CD4+ T-cell responses.Funding: GlaxoSmithKline Biologicals SA
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wilkinson, T., Schembri, S., Brightling, C., Bakerly, N. D., Macnee, W., Rombo, L., Hedner, J., Allen, M., Walker, P., De Ryck, I., Tasciotti, A., Casula, D., Testa, M., Arora, A. K. Tags: Clinical Problems Source Type: research

Racial Disparities in the Utilization of Recommended Supportive Care Among Patients with Multiple Myeloma in the United States
Conclusion: We found significant under-utilization of supportive care measures focused at bone health and infection prevention among elderly adults with MM in the US. Similar to prior work evaluating utilization of novel MM therapies and transplantation, we found significant racial disparities in receipt of MM supportive care. Future studies should seek to identify reasons for such under-utilization of supportive care during MM therapy so that appropriate interventions may be implemented.DisclosuresZeidan: Agios: Consultancy; Celgene: Consultancy; Novartis: Consultancy; Incyte: Employment; Gilead: Consultancy; Ariad: Consu...
Source: Blood - November 21, 2018 Category: Hematology Authors: Giri, S., Zhu, W., Wang, R., Zeidan, A. M., Podoltsev, N. A., Gore, S. D., Ma, X., Davidoff, A. J., Huntington, S. F. Tags: 902. Health Services Research-Malignant Diseases: Quality Of Life Studies Source Type: research

Quality of Care Indicators in Patients with Sickle Cell Disease (SCD): Influenza Vaccination and Routine Eye Examination Are Associated with Outpatient Utilization but Not Acute Hospital Care, Whereas Comorbidity Indexes Are Strongly Associated with Both
In conclusion, outpatient-based candidate quality indicators of care examined (influenza vaccination and eye examination), were associated with increased outpatient utilization, but not acute visits or hospitalizations. Co-morbidity indexes have significant confounding effects on outpatient and hospital utilization. Administrative data based quality indicators of care such as influenza vaccination, as well as SCD specific comorbidity indexes warrant further studies as these may help better understand optimal allocation of health care resources for patients with SCD.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Adamkiewicz, T., Baltrus, P., Li, C., Carter-Wicker, K., Gaglioti, A. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster II Source Type: research

Novel imiquimod nanovesicles for topical vaccination
Publication date: 1 February 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 174Author(s): Ayelen Tatiana Caimi, Maria Julia Altube, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Ana Paula Perez, Eder Lilia Romero, Maria Jose MorillaAbstractDevelopment of needle and pain free noninvasive immunization procedures is a top priority for public health agencies. In this work the topical adjuvant activity of the immunomodulator imiquimod (IMQ) carried by ultradeformable archaeosomes (UDA2) (nanovesicles containing sn-2,3 ether linked phytanyl saturated archaeolipids) was surveyed and compared with that of ult...
Source: Colloids and Surfaces B: Biointerfaces - November 28, 2018 Category: Biochemistry Source Type: research