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Total 89913 results found since Jan 2013.
Prof. Transient receptor potential vanilloid 4 promotes the growth of non-small cell lung cancer by regulating Foxp3
CONCLUSIONS: Antitumor effects caused by TRPV4 inhibition in NSCLC might be attributed to the suppression of Foxp3 which induced subsequent cell apoptosis. Thus, pharmacological inhibition of TRPV4 may be a promising option for NSCLC treatment.PMID:34995050 | DOI:10.18388/abp.2020_5614
Source: Acta Biochim Pol - January 7, 2022 Category: Biochemistry Authors: Jiang-Tao Pu Tao Zhang Kai-Ming He Deng-Guo Zhang Zhang-Yu Teng Yun-Fei Wu Source Type: research
Mammalian diaphanous-related formin 1 is required for motility and invadopodia formation in human U87 glioblastoma cells.
In conclusion, our data demonstrate that mDRF1 is highly expressed in human glioma tissue. The knockdown of mDRF1 in U87 MG cells led to a sharp decline in their invasive and metastatic ability, which effectively reduced the spread of glioma cells into the surrounding areas. To our knowledge, this is the first report showing that mDRF1 is a promising target for the treatment of malignant gliomas.
PMID: 24317603 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - December 5, 2013 Category: Molecular Biology Authors: Li Z, Xu Y, Zhang C, Liu X, Jiang L, Chen F Tags: Int J Mol Med Source Type: research
Specific inhibition of HDAC4 in cardiac progenitor cells enhances myocardial repairs
We have recently shown that in vivo inhibition of histone deacetylase (HDAC) stimulates endogenous myocardial regeneration in infarcted hearts (Zhang L et al. J Pharmacol Exp Ther 341: 285–293, 2012). Furthermore, our observation demonstrates that HDAC inhibition promotes cardiogenesis, which is associated with HDAC4 reduction. However, it remains unknown as to whether specific inhibition of HDAC4 modulates cardiac stem cells (CSCs) to facilitate myocardial repair and to preserve cardiac performance. c-kit+ CSCs were isolated from adult mouse hearts and were transfected with HDAC4 siRNA to knockdown HDAC4 of c-kit+ C...
Source: AJP: Cell Physiology - August 15, 2014 Category: Cytology Authors: Zhang, L. X., DeNicola, M., Qin, X., Du, J., Ma, J., Tina Zhao, Y., Zhuang, S., Liu, P. Y., Wei, L., Qin, G., Tang, Y., Zhao, T. C. Tags: ARTICLES Source Type: research
Fighting against kidney diseases with small interfering RNA: opportunities and challenges
The significant improvements in siRNA therapy have been achieved, which have great potential applications in humans. The kidney is a comparatively easy target organ of siRNA therapy due to its unique structural and functional characteristics. Here, we reviewed recent achievements in siRNA design, delivery and application with focuses on kidney diseases, in particular kidney transplant-related injuries. In addition, the strategy for increasing serum stability and immune tolerance of siRNA was also discussed. At last, the future challenges of siRNA therapy including organ/tissue/cell-specific delivery and time-controlled sil...
Source: Journal of Translational Medicine - February 1, 2015 Category: Research Authors: Cheng YangChao ZhangZitong ZhaoTongyu ZhuBin Yang Source Type: research
The effects of RNA interference mediated VEGF gene silencing on biological behavior of renal cell carcinoma and transplanted renal tumor in nude mice.
CONCLUSION: The VEGF gene silencing could inhibit the cell proliferation, migration and invasion of RCC 786-O cells; inhibition of VEGF protein expression could prevent transplanted RCC growth and tumor angiogenesis.
PMID: 26484606 [PubMed - as supplied by publisher]
Source: Cancer Biomarkers : Section A of Disease Markers - September 30, 2015 Category: Cancer & Oncology Authors: Sun SQ, Cheng ZH, Wang S, Sun XW, Chen G, Zhang Y, Gu M, Yao HJ, Wang Z, Zhou J, Peng YB, Xu MX, Zhang K, Wang Q Tags: Cancer Biomark Source Type: research
Effect of lentivirus-mediated gene silencing, targeting toll-like receptor 2, on corneal allograft transplantation in rats
Conclusions LV mediated TLR2 siRNA could effectively down regulate the TLR2 expression via RNA interference and prolong the survival of corneal grafts, although not necessarily able to prevent the rejection.
Source: Molecular Immunology - September 8, 2017 Category: Allergy & Immunology Source Type: research
LncRNA ANRIL affects the sensitivity of ovarian cancer to cisplatin via regulation of let-7a/HMGA2 axis.
Abstract
This paper tried to explore ANRIL expression in ovarian cancer and how it affects cisplatin-sensitivity of ovarian cancer cells via regulation of let-7a/HMGA2 axis. qRT-PCR was used to detect ANRIL and let-7a levels in ovarian cancer tissues and cell lines (SKOV3 and SKOV3/DDP). Then cells were randomly assigned into Blank, NC siRNA, ANRIL siRNA, let-7a inhibitor, and ANRIL siRNA+let-7a inhibitor groups. CCK-8 assay was applied for assessing cell viability of cells treated with different concentrations of cisplatin . Flow cytometry was employed to test cell apoptosis rate. QRT-PCR and Western blot were pe...
Source: Bioscience Reports - June 11, 2019 Category: Biomedical Science Authors: Miao JT, Gao JH, Chen YQ, Chen H, Meng HY, Lou G Tags: Biosci Rep Source Type: research
Reviewing Approaches to Treating Transthyretin Amyloidosis
Transthyretin amyloidosis may be a primary component of the present limit on human longevity. Transthyretin is one of the few proteins in the human body that can misfold in ways that encourage other molecules of the same protein to misfold in the same way, joining together form solid aggregates that disrupt cell and tissue function. This is particularly an issue in the cardiovascular system, and while it is presently thought that transthyretin amyloidosis only contributes to a minority of fatal cardiovascular disease in younger old age, autopsies of supercentenarians suggested that it is the major cause of death in the old...
Source: Fight Aging! - November 3, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Pharmacological strategies for protection of extrahepatic islet transplantation.
This article gathers courses and conditions that lead to islet loss, from organ procurement through islet transplantation, with special emphasis on hypoxia, oxidative stress, and antigen non-specific inflammation, and reviews strategies using pharmacological agents that have shown effectiveness in protecting islets, including a new treatment approach utilizing siRNA. Pharmacological agents that support islet survival and promote β-cell proliferation are also included. Treatment of donor pancreata and/or islets with these agents should increase the effectiveness of islets transplanted into extrahepatic sites. Furthermore, ...
Source: Minerva Endocrinologica - June 4, 2015 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Abstract A07: Knockdown laminin-511 expression blocked endlthelial cell function in vitro and angiogenesis in vivo knockout skin model
In conclusion, our data suggested a possible involvement of laminin-511 in integrin alphaV and beta3-dependent angiogenesis and blood vessel maturation. Our works revealed the important roles of laminin-511 in endothelial cell activities, which proved its significance for angiogenesis.Citation Format: Jie Li, Tengjiao Cui. Knockdown laminin-511 expression blocked endlthelial cell function in vitro and angiogenesis in vivo knockout skin model. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Angiogenesis and Vascular Normalization: Bench to Bedside to Biomarkers; Mar 5-8, 2015; Orlando, FL. Philadelphia (PA...
Source: Molecular Cancer Therapeutics - December 6, 2015 Category: Cancer & Oncology Authors: Li, J., Cui, T. Tags: Antiangiogenic Therapy: Poster Presentations - Proffered Abstracts Source Type: research
Theranostical nanosystem‐mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma
In conclusion, the theranostic siRNA nanomedicine examined here possesses great theranostic potential for combined gene therapy and MRI diagnosis of HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 1, 2015 Category: Internal Medicine Authors: Yu Guo, Jing Wang, Lu Zhang, Shunli Shen, Ruomi Guo, Yang Yang, Wenjie Chen, Yiru Wang, Guihua Chen, Xintao Shuai Tags: Hepatobiliary Malignancies Source Type: research
Evaluation of umbilical cord blood CD34+ hematopoietic stem cells expansion with inhibition of TGF-β receptorII in co-culture with bone marrow mesenchymal stromal cells.
CONCLUSION: The results showed that transfection of CD34(+) cells with SiRNA targeting TGF-βRII and their co-culture with MSCs could considerably increase the number of progenitors. Therefore, this method could be useful for UCB-HSCs expansion.
PMID: 27344285 [PubMed - as supplied by publisher]
Source: Tissue and Cell - June 7, 2016 Category: Cytology Authors: Sohrabi Akhkand S, Amirizadeh N, Nikougoftar M, Alizadeh J, Zaker F, Sarveazad A, Joghataei MT, Faramarzi M Tags: Tissue Cell Source Type: research
