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Vaccination: Vaccines

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Total 86785 results found since Jan 2013.

Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection.
Abstract RV144 remains the only HIV-1 vaccine trial to demonstrate efficacy against HIV-1 acquisition. The prespecified analysis of immune correlates of risk showed that antibodies directed against the V1V2 region of gp120, in particular the IgG1 and IgG3 subclass mediating antibody-dependent cellmediated cytotoxicity, seem to play a predominant role in protection against HIV-1 acquisition and that plasma envelope (Env)-specific IgA antibodies were directly correlated with risk. RV144 and recent nonhuman primate challenge studies suggest that Env is essential, and perhaps sufficient, to induce protective antibody ...
Source: Annual Review of Medicine - October 17, 2014 Category: Journals (General) Authors: Kim JH, Excler JL, Michael NL Tags: Annu Rev Med Source Type: research

Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: search for the "magic bullet" to kill cccDNA.
This article forms part of a symposium in Antiviral Research on "An unfinished story: from the discovery of the Australia antigen to the development of new curative therapies for hepatitis". PMID: 26476376 [PubMed - as supplied by publisher]
Source: Antiviral Research - October 14, 2015 Category: Virology Authors: Zhang E, Kosinska A, Lu M, Yan H, Roggendorf M Tags: Antiviral Res Source Type: research

Abstract IA07: In search of racial disparities in HPV vaccination
Background: Racial disparities in cervical cancer deaths are longstanding, with African American and Latina women more likely to die from the disease. The advent of HPV vaccine created an opportunity to reduce or end these disparities, but only if uptake was either uniformly high across all females or higher among minority than non-minority females. Thus, interest in racial disparities in HPV vaccine coverage has been understandably high.Findings: Data from several sources show racial disparities and "reverse disparities" in HPV vaccination coverage. First, the most reliable national data are from the National Immunization...
Source: Cancer Epidemiology Biomarkers and Prevention - September 30, 2015 Category: Cancer & Oncology Authors: Brewer, N. T., Moss, J. L., Reiter, P. L. Tags: Vaccines and Immunoprevention: Oral Presentations - Invited Abstracts Source Type: research

Search Engine Ranking, Quality, and Content of Web Pages That Are Critical Versus Noncritical of Human Papillomavirus Vaccine
Online information can influence attitudes toward vaccination. The aim of the present study was to provide a systematic evaluation of the search engine ranking, quality, and content of Web pages that are critical versus noncritical of human papillomavirus (HPV) vaccination.
Source: Journal of Adolescent Health - November 7, 2015 Category: Child Development Authors: Linda Y. Fu, Kathleen Zook, Zachary Spoehr-Labutta, Pamela Hu, Jill G. Joseph Tags: Original article Source Type: research

Vaccine donation supports search dogs
DOGS belonging to the Search and Rescue Dog Association (SARDA) England have received a free health check and vaccinations thanks to support from the veterinary corporate group CVS. The charity's dogs are all owned by their handlers and have recently completed a deployment helping in the parts of the UK that were hit by flooding over the winter, including Cumbria and Yorkshire. During their March national training weekend at the Castleshaw Outdoor Centre in Oldham, Vicky Weedon, a vet at the CVS practice West Mount Vets, gave all the dogs a health check and vaccinated them. Ms Weedon has a long-standing relationship with t...
Source: Veterinary Record - March 23, 2016 Category: Veterinary Research Tags: News and Reports Source Type: research

Herpes zoster and the search for an effective vaccine.
This article reviews VZV pathogenesis, host responses and current vaccines available to prevent herpes zoster. This article is protected by copyright. All rights reserved. PMID: 27164323 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - May 9, 2016 Category: Allergy & Immunology Authors: Arnold N, Messaoudi I Tags: Clin Exp Immunol Source Type: research

Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets
Publication date: Available online 21 July 2017 Source:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Author(s): Mahmoud H. el Kouni Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is curren...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - July 21, 2017 Category: Molecular Biology Source Type: research

US Health Care Clinicians' Knowledge, Attitudes, and Practices Regarding Human Papillomavirus Vaccination: A  Qualitative Systematic Review
Publication date: March 2018 Source:Academic Pediatrics, Volume 18, Issue 2, Supplement Author(s): Brittany L. Rosen, Allie Shepard, Jessica A. Kahn Clinicians' recommendation for the human papillomavirus (HPV) vaccine appears to be an important driver of parental decisions about vaccination. Our aim was to synthesize the best available evidence exploring the perceptions and experiences regarding HPV vaccination, from the perspective of the US clinician. We conducted a comprehensive literature search of Academic Search Complete, CINAHL Plus, Communication & Mass Media Complete, Consumer Health Complete (EBSCOhost)...
Source: Academic Pediatrics - March 1, 2018 Category: Pediatrics Source Type: research

IJERPH, Vol. 15, Pages 1432: In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children Before the Administration of the First Booster
Conclusions: Immunomodulation considered on the example of titre of IgG antibody to pertussis can serve as a useful model of the assessment of development of acquired immunity after mandatory vaccinations.
Source: International Journal of Environmental Research and Public Health - July 6, 2018 Category: Environmental Health Authors: Anna Bednarek Anna Bodajko-Grochowska Barbara Hasiec Robert Klepacz Katarzyna Szczekala Danuta Zarzycka Andrzej Emeryk Tags: Article Source Type: research

Secret-AAR: A web server to assess the antigenic density of proteins and homology search against bacterial and parasite secretome proteins.
Abstract The secretome refers to all the Excreted/Secreted (ES) proteins, and these are involved in critical biological processes, such as cell-cell communication, and host immune response. Recently, we introduced the abundance of antigenic regions (AAR) value to assess the protein antigenic density and to evaluate the antigenic potential of secretomes. Here, to facilitate the AAR calculation, we implemented it as a user-friendly webserver. We extended the webserver capabilities implementing a sequence-based tool for searching homologous proteins across secretomes, including experimental and predicted secretomes o...
Source: Genomics - October 11, 2018 Category: Genetics & Stem Cells Authors: Cornejo-Granados F, Hurtado-Ramírez JM, Hernández-Pando R, Ochoa-Leyva A Tags: Genomics Source Type: research

Transcriptomics of Haemophilus (Gl ässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens
Haemophilus (Gl ässerella) parasuis is the etiological agent of Glässer’s disease in pigs. Control of this disorder has been traditionally based on bacterins. The search for alternative vaccines has focused mainly...
Source: BMC Veterinary Research - November 6, 2018 Category: Veterinary Research Authors: Álvaro Álvarez-Estrada, César B. Gutiérrez-Martín, Elías F. Rodríguez-Ferri and Sonia Martínez-Martínez Tags: Research article Source Type: research

Cancers, Vol. 10, Pages 492: Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?
nin To date, no targeted drugs, antibodies or combinations of chemotherapeutics have been demonstrated to be more efficient than temozolomide, or to increase efficacy of standard therapy (surgery, radiotherapy, temozolomide, steroid dexamethasone). According to recent phase III trials, standard therapy may ensure a median overall survival of up to 18–20 months for adult patients with newly diagnosed glioblastoma. These data explain a failure of positive non-controlled phase II trials to predict positive phase III trials and should result in revision of the landmark Stupp trial as a historical control for ...
Source: Cancers - December 5, 2018 Category: Cancer & Oncology Authors: Aleksei A. Stepanenko Vladimir P. Chekhonin Tags: Review Source Type: research

Search of Hepatitis-B infection in relatives of chronic carriers in the province of Huanta, Ayacucho, Peru.
In conclusion, we found a high frequency of HBV in relatives of carriers of HBsAg. This strategy would help identify chronic carriers that can be treated and to contribute to a plan for the elimination of HBV. PMID: 30726419 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - February 7, 2019 Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research

Twitter cracks down on anti-vaxx content with new search tools
Users will now be directed to a 'credible public health resource' when they conduct a search using specific keywords associated with vaccines, Twitter said on Tuesday.
Source: the Mail online | Health - May 15, 2019 Category: Consumer Health News Source Type: news

Africa: The Search for an Effective HIV Vaccine Continues
[The Conversation Africa] An HIV vaccine trial that started in 2016 in South Africa was halted in February 2020. The study sponsors made the call after interim results showed that the vaccine, known as HVTN 702, did not prevent HIV. This result was disappointing, but the search for an effective HIV vaccine continues. Anatoli Kamali speaks to The Conversation Africa's Ina Skosana about other developments in the field.
Source: AllAfrica News: HIV-Aids and STDs - February 17, 2020 Category: Infectious Diseases Source Type: news