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Nutrition: Vitamins
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Signaling mechanism of growth hormone-releasing hormone receptor
Vitam Horm. 2023;123:1-26. doi: 10.1016/bs.vh.2023.06.004. Epub 2023 Jul 7.ABSTRACTThe hypothalamic peptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Splice variants of GHRH-Rs (SV) in human tumors and other extra pituitary tissues were identified and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R an...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Gabor Halmos Zsuzsanna Szabo Eva Juhasz Andrew V Schally Source Type: research
Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti-inflammatory, anti-micro...
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Muahmmad Ali Khan Dina M El-Kersh Md Shafiqul Islam Shams Ara Khan Hossam Kamli Chandan Sarkar Md Shimul Bhuia Tawhida Islam Manik Chandra Shill Glenda C Gobe Eda S önmez Gürer William N Setzer Javad Sharifi-Rad Muhammad Torequl Islam Source Type: research
Vitamin D supplementation improves the therapeutic effect of mometasone on allergic rhinitis
This study aimed to investigate the efficacy and safety of vitamin D supplementation in the treatment of allergic rhinitis (AR) using mometasone. A total of 140 patients with moderate and severe AR treated at our hospital between January 2017 and August 2020 were recruited as subjects for this study. The patients were randomly divided into control and experimental groups, with 70 patients in each group. Mometasone nasal spray was used in both groups, and vitamin D was administered to the experimental group for four weeks. The total nasal symptom scores (TNSS) and rhinoconjunctivitis quality of life questionnaire (RQLQ) wer...
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Minfei Guo Source Type: research
Prevalence and predictors of vitamin D deficiency among adults with epilepsy: A cross-sectional study
CONCLUSION: Vitamin D deficiency among PWE is prevalent in our local population, suggesting that regular screening should be considered for those at risk. Early identification would allow intervention to reduce the risk of future complications.PMID:37716324 | DOI:10.1016/j.yebeh.2023.109432
Source: Epilepsy and Behaviour - September 16, 2023 Category: Neurology Authors: Ching Soong Khoo Mohd Fadzli Shukor Juen Kiem Tan Michelle Maryanne Tan Li Ling Yong Siti Zaleha Sahibulddin Siti Hajar Mat Desa Norasyikin A Wahab Rozita Hod Hui Jan Tan Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti-inflammatory, anti-micro...
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Muahmmad Ali Khan Dina M El-Kersh Md Shafiqul Islam Shams Ara Khan Hossam Kamli Chandan Sarkar Md Shimul Bhuia Tawhida Islam Manik Chandra Shill Glenda C Gobe Eda S önmez Gürer William N Setzer Javad Sharifi-Rad Muhammad Torequl Islam Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Environment International - September 16, 2023 Category: Environmental Health Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Environment International - September 16, 2023 Category: Environmental Health Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Chemical profile of Roselle extract and its inhibitory activities on three digestive enzymes in vitro and in vivo
Int J Biol Macromol. 2023 Sep 13:126902. doi: 10.1016/j.ijbiomac.2023.126902. Online ahead of print.ABSTRACTRoselle is rich in an extensive diversity of beneficial substances, including phenolic acids, amino acids, anthocyanins, vitamins, and flavonoids. Herein, the chemical constituents in Roselle extract (RE) were identified by UPLC-DAD-QTOF-MS. Besides, its inhibitory effects on three digestive enzymes, i.e. α-amylase, α-glucosidase, and pancreatic lipase, were investigated in both in vitro and in vivo. Thirty-three constituents including hibiscus acid, 18 phenolic acids, 2 anthocyanins and 12 flavonoids were identifi...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Dan Yang Xin-Yu-Yao Ding Hai-Xia Xu Yu-Xian Guo Qing-Feng Zhang Source Type: research
Method for Vitamin D Deficiency Screening
Biomed Environ Sci. 2023 Aug 20;36(8):785. doi: 10.3967/bes2023.109.NO ABSTRACTPMID:37711094 | DOI:10.3967/bes2023.109
Source: Biomedical and Environmental Sciences : BES - September 15, 2023 Category: Biomedical Science Source Type: research
Vitamin E and diabetic foot ulcers
Curr Diabetes Rev. 2023 Sep 14. doi: 10.2174/1573399820666230914155232. Online ahead of print.ABSTRACTThis narrative mini-review discusses vitamin E levels in subjects with diabetic foot ulcers (DFUs). Vitamin E may be reduced in subjects with DFUs, but this finding is inconsistent. Its administration appears to benefit patients with DM, delaying the onset of complications, including DFU. There is also evidence that it may promote DFU healing. Nonetheless, further studies are required to confirm these promising results and estimate vitamin E administration's cost-effectiveness.PMID:37711108 | DOI:10.2174/1573399820666230914155232
Source: Current Diabetes Reviews - September 15, 2023 Category: Endocrinology Authors: Nikolaos D Karakousis Elisavet E Pyrgioti Petros N Georgakopoulos Dimitrios S Karagiannakis Nikolaos Papanas Source Type: research
Managing osteoporosis in COPD
Endocr Metab Immune Disord Drug Targets. 2023 Sep 13. doi: 10.2174/1871530323666230913105752. Online ahead of print.ABSTRACTChronic obstructive pulmonary disease (COPD) is a serious respiratory disease with high morbidity, disability and mortality worldwide. Every year, many people die from the disease or its comorbidities. Osteoporosis is a common complication of COPD, which can lead to increased fractures in COPD patients, aggravate the disease, and then bring great pain and burden to patients. The possible factors leading to osteoporosis in COPD patients include systemic inflammation, corticosteroid use, vitamin D defic...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Lilan Shen Juanqin Lv Jie Li Jing Zhou Xiaomin Wang Source Type: research
