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Total 41192 results found since Jan 2013.

The Search for the Elusive Elixir of Life
By TOM EMERICK Here’s the executive summary: Most disease and health spending is age-related. As we age we get infirmities ranging from dementia to cancer to vascular disease. Nothing can prevent aging. Period. For millennia mankind has been been on a futile search to prevent aging. Search for the Elusive Elixir of Life For 3500 or more years mankind has been searching for the mythological Elixir of Life, the fountain of youth, the philosophers stone, pool of nectar, etc, that will defeat aging and extend life, if not achieve immortality. According to Wiki, “The elixir of life, also known as the elixir of immortality a...
Source: The Health Care Blog - February 4, 2016 Category: Consumer Health News Authors: Simon Nath Tags: THCB Tom Emerick Source Type: blogs

Association Between Vitamin D and Novel SARS-CoV-2 Respiratory Dysfunction – A Scoping Review of Current Evidence and Its Implication for COVID-19 Pandemic
ConclusionOur rapid review of literature supports the need for observational studies with COVID-19 infected populations to measure and assess vitamin D levels in relation to risk/severity and outcomes; alongside RCTs designed to evaluate the efficacy of supplementation both in preventive and therapeutic contexts. The overlap in the vitamin D associated biological pathways with the dysregulation reported to drive COVID-19 outcomes warrants further investigation.
Source: Frontiers in Physiology - November 26, 2020 Category: Physiology Source Type: research

Evidence From Web-Based Dietary Search Patterns to the Role of B12 Deficiency in Non-Specific Chronic Pain: A Large-Scale Observational Study
Conclusions: Our findings show that Internet search patterns are a useful way of investigating health questions in large populations, and suggest that low B12 intake may be associated with a broader spectrum of neurological disorders than previously thought.
Source: Journal of Medical Internet Research - January 5, 2018 Category: General Medicine Authors: Eitan Giat Elad Yom-Tov Source Type: research

Nutritional Factors and Preservation of C-Peptide in Youth With Recently Diagnosed Type 1 Diabetes: SEARCH Nutrition Ancillary Study.
CONCLUSIONS Increased intake of branched-chain amino acids and long-chain omega-3 fatty acids may support preservation of β-cell function. This represents a new direction for research to improve prognosis for type 1 diabetes. PMID: 23801797 [PubMed - in process]
Source: Diabetes Care - July 1, 2013 Category: Endocrinology Authors: Mayer-Davis EJ, Dabelea D, Crandell JL, Crume T, D'Agostino RB, Dolan L, King IB, Lawrence JM, Norris JM, Pihoker C, The N Tags: Diabetes Care Source Type: research

Serum biochemical, blood gas and antioxidant status in search and rescue dogs before and after simulated fieldwork
Publication date: Available online 6 July 2015 Source:The Veterinary Journal Author(s): J.W. Spoo , D.L. Zoran , R.L. Downey , K. Bischoff , J.J. Wakshlag The aim of the study was to assess the physiological and antioxidant status before and after a 4 h search and rescue field exercise, with handlers, under warm-weather conditions performing activities compared to a control group of similarly trained dogs at rest. Serum chemistry demonstrated a decrease in serum sodium (Na) and potassium (K) in both exercising and control groups, however only Na was decreased significantly (P < 0.05) after exercise and hematocrits...
Source: The Veterinary Journal - July 7, 2015 Category: Veterinary Research Source Type: research

Health economic analyses of psoriasis management: a systematic literature search
The objective was to identify health economic evaluations of psoriasis treatments that have been published to date. Of particular interest were the mostly used analysis and outcome parameters, the compared treatments, and the question, if available health economic studies may be used to perform a meta-analysis of qualitative findings. A systematic literature search using PubMed Medline, Ovid Medline, and Cochrane Library was performed for articles, published and available until mid of January 2016. Among the key words were the terms “psoriasis” and “cost-effectiveness”. The search resulted in 318 articles without d...
Source: Archives of Dermatological Research - July 18, 2016 Category: Dermatology Source Type: research

Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer
Conclusions: Many RCTs of anticoagulation in patients with cancer appear to use insufficiently rigorous outcome assessment methods and to have deficiencies in key methodological features. It is not clear whether this reflects a problem in the design, conduct or the reporting of these trials, or both. Future trials should avoid the shortcomings described in this article.
Source: BioMed Central - February 14, 2013 Category: Journals (General) Authors: Gabriel RadaHolger J SchünemannNawman LabediPierre El-HachemVictor KairouzElie A Akl Source Type: research

What Causes Hypercalcemia?
Discussion Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here. Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium. Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children.
Conclusions:Vitamin D deficiency, based on PTH elevation, was best defined by a 25OHD level of < 34 nmol/l. Since deficient calcium supply often co-exists with vitamin D deficiency and both can independently cause nutritional rickets, a threshold for the skeletal effects of vitamin D should not be based purely on 25OHD levels.Pediatric Research (2013); doi:10.1038/pr.2013.139. PMID: 23999068 [PubMed - as supplied by publisher]
Source: Pediatric Research - September 2, 2013 Category: Pediatrics Authors: Atapattu N, Shaw N, Högler W Tags: Pediatr Res Source Type: research

Title: In Search of “Just Right”: The Challenge of Regulating Arsenic in Rice
Charles W. Schmidt, MS, an award-winning science writer from Portland, ME, has written for Discover Magazine, Science, and Nature Medicine. Background image: © Koji Kitagawa/amanaimages/Corbis About This Article open Citation: Schmidt CW. 2015. In search of “just right”: the challenge of regulating arsenic in rice. Environ Health Perspect 123:A16–A19; http://dx.doi.org/10.1289/ehp.123-A16 News Topics: Agriculture and Farming, Arsenic, Diet and Nutrition, Drinking Water Quality, Food Safety and Regulation, Laws, Regulations, and Policy, Risk Assessment, Soil Pollution, Standards Published: 1 January 2015 PDF Ver...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Featured News Spheres of Influence Agriculture and Farming Arsenic Diet and Nutrition Drinking Water Quality Food Safety and Regulation Risk Assessment Soil Pollution Standards Source Type: research

Longitudinal associations of nutritional factors with glycated hemoglobin in youth with type 1 diabetes: the SEARCH Nutrition Ancillary Study.
CONCLUSIONS: Several nutritional factors may be associated with Hb A1c during early stages of disease progression in youth recently diagnosed with T1D. In addition to the overall role of major macronutrients such as carbohydrates and protein, leucine and n-3 fatty acid intakes, such as of EPA, may be important for long-term glycemic control. PMID: 25948670 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 6, 2015 Category: Nutrition Authors: Lamichhane AP, Crandell JL, Jaacks LM, Couch SC, Lawrence JM, Mayer-Davis EJ Tags: Am J Clin Nutr Source Type: research

Have we Been Hooked on Micronutrients in our Search for the Solution to Stunting?
Co-author Richard D. Semba, Johns Hopkins University Today, some 160 million children under five years of age don't get the food and nutrients that their bodies need for optimal growth and development. One hundred and sixty million children that are likely to remain trapped in a vicious cycle of malnutrition and poverty. No wonder the 'new' Sustainable Development Goals (SDGs) have 'no poverty' and 'zero hunger' as the first and second of the 17 Global Goals. This makes the eradication of malnutrition, with a special focus on children, a top priority for countries as they turn the SDGs into actions. To support the SDGs,...
Source: Science - The Huffington Post - April 1, 2016 Category: Science Source Type: news

WCRF-AICR continuous update project: Systematic literature review of prospective studies on circulating 25-hydroxyvitamin D and kidney cancer risk
Publication date: November 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology, Volume 164 Author(s): Andrea L. Darling, Leila Abar, Teresa Norat As part of the World Cancer Research Fund/American Institute for Cancer Research (WCRF–AICR) Continuous Update project we performed a systematic review of prospective studies with data for both measured or predicted 25(OH)D concentration and kidney cancer risk. PubMed was searched from inception until 1st December 2014 using WCRF/AICR search criteria. The search identified 4 papers suitable for inclusion, reporting data from three prospective cohort studies, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - October 30, 2016 Category: Biochemistry Source Type: research

Serum 25-Hydroxyvitamin D Insufficiency in Search of a Bone Disease.
Conclusion: At a threshold of 25(OH)D of 30 nmol/L or below, abnormalities in biochemical features are supportive of the notion of a 'deficiency' state predisposing to bone disease. However, no deleterious effects are found in subjects within an 'insufficient' threshold of 25(OH)D of 30 to 75 nmol/L which challenges the rationale in using supplementation of these individuals. PMID: 28379394 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 30, 2017 Category: Endocrinology Authors: Shah S, Chiang C, Sikaris K, Lu Z, Bui M, Zebaze R, Seeman E Tags: J Clin Endocrinol Metab Source Type: research