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Total 44467 results found since Jan 2013.
Association between weight loss agents and elevated liver enzymes: a population-based cross-sectional study
This study aimed to investigate the associations between weight loss agents and elevated liver enzymes at the population-level. We conducted a cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data from 2013 to 2019. This study included 36,259 participants over 20 years of age who completed the questionnaire and had no history of hepatitis, cancer, or renal failure. In these participants, we analyzed associations between weight loss agents and elevated liver enzymes by constructing multiple logistic regression models with adjustment for confounding factors and stratified by sex, a...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ye-Jee Kim Seo Young Kang Mi-Sook Kim Joongyub Lee Bo Ram Yang Source Type: research
Alleviation of ultraviolet ‐B radiation‐induced photoaging using Saussurea medusa Maxim polysaccharide
Ultraviolet B radiation from sunlight can lead to photoaging, thickening of the dermis, and deep wrinkles. It triggers the production of inflammatory factors like TNF-a and IL-1, which then activate EGFR receptors in cells. This, in turn, activates MEK1/2 and ERK1/2, eventually causing an increase in the production of MMPs. The increased MMPs then degrade collagen and other extracellular matrix components, leading to skin inflammation and damage. However, the polysaccharides present inSaussurea medusa maxim can mitigate skin damage by this pathway. AbstractSaussureamedusa polysaccharide, the polysaccharide extract ofSaussu...
Source: Photochemistry and Photobiology - September 22, 2023 Category: Science Authors: Yan Guo,
Yue Kong,
Juan Sun,
Yang Jiao,
Yan Hong,
Yan Wang Tags: RESEARCH ARTICLE Source Type: research
Molecules, Vol. 28, Pages 6767: Antioxidant Properties and Secondary Metabolites Profile of Hyptis colombiana at Various Phenological Stages
In this study, H. colombiana plants at different phenological stages (vegetative, flowering, and post-flowering) were harvested to obtain essential oils (EOs) and extracts (from fresh plant materials or post-distillation waste) whose chemical compositions and antioxidant activities were determined. H. colombiana EOs distilled by microwave-assisted hydrodistillation were analyzed by GC/MS/FID, and hydroalcoholic extracts obtained from fresh plant materials or post-distillation waste were analyzed by UHPLC-ESI+/−-Orbitrap-MS. The antioxidant activity was evaluated by the ABTS+• and ORAC assays. The...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Sheila B. Beltr án Lady J. Sierra Jos é L. Fernández-Alonso Angie K. Romero Jairo R. Mart ínez Elena E. Stashenko Tags: Article Source Type: research
Molecules, Vol. 28, Pages 6751: Investigation of the Mechanism of Action of Periploca forrestii Schltr. Extract on Adjuvant Collagen Rats Based on UPLC-Q-Orbitrap-HRMS Non-Targeted Lipidomics
in Zhou
Periploca forrestii Schltr. (P. forrestii) is a classical medicinal plant and is commonly used in traditional medicine for the treatment of rheumatoid arthritis, soft tissue injuries, and traumatic injuries. The aim of this study was to evaluate the anti-arthritic effects of three fractions of P. forrestii alcoholic extracts (PAE), P. forrestii water extracts (PWE), and total flavonoids from P. forrestii (PTF) on Freund’s complete adjuvant (FCA)-induced arthritis in rats, and to use a non-targeted lipidomic method to investigate the mechanism of action of the three fractions of P. forrestii in the...
Source: Molecules - September 22, 2023 Category: Chemistry Authors: Silan An Xiaoting Yan Huaguo Chen Xin Zhou Tags: Article Source Type: research
Practice of complementary and alternative medicine use in North Indian children with type 1 diabetes: an exploratory study
ConclusionCAM, mostly herbal, is frequently used among children with T1DM in North India and has detrimental effects on glycemic control. This information should be used during diabetes education to avoid medical emergencies related to sub-optimal insulin dosing.
Source: Diabetology International - September 22, 2023 Category: Endocrinology Source Type: research
Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction
In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.PMID:37733287 | DOI:10.1007/s12272-023-01460-3
Source: Archives of Pharmacal Research - September 21, 2023 Category: Drugs & Pharmacology Authors: Jie Xu Aizhen Xiong Xunjiang Wang Xing Yan Yilin Chen Xuanling Ye Zhengtao Wang Lili Ding Li Yang Source Type: research
Randomised controlled trial of Jiandu granule in preventing chemoradiotherapy-induced oral mucositis
CONCLUSION: Jiandu granule reduced the incidence of severe oral mucositis in nasopharyngeal carcinoma patients during concurrent chemoradiotherapy and had an acceptable safety profile.PMID:37731218 | DOI:10.1111/odi.14745
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Huakang Li Jianlong Ke Xiaoyan Wang Bo Xu Qiang Li Ziliang Wu Yue Wang Bing Lin Source Type: research
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Biomed Pharmacother. 2023 Sep 19;167:115502. doi: 10.1016/j.biopha.2023.115502. Online ahead of print.ABSTRACTPatients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological mechanisms behind diabetic hepatopathy are complex, some of them include fatty acid accumulation, increased reactive oxygen species, increased advanced glycation end-products, hyperactivity of polyol pathways, increased apoptosis and necrosis, and promotion of fibrosis. A growing number of studies have shown that herbal extracts and their a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Leila Mobasheri Mitra Ahadi Ali Beheshti Namdar Mohaddeseh Sadat Alavi Abolfazl Bemidinezhad Seyed Mostafa Moshirian Farahi Mahdi Esmaeilizadeh Niloofar Nikpasand Elham Einafshar Ahmad Ghorbani Source Type: research
Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions
Biomed Pharmacother. 2023 Sep 19;167:115545. doi: 10.1016/j.biopha.2023.115545. Online ahead of print.ABSTRACTHypericin is widely utilized for its precise antidepressant properties, but its exact antidepressant mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes in the central nervous system, are concerned with the pathogenesis of depression. However, the role of hypericin in gap junctional dysfunction in depression has rarely been investigated. Here, we found that gap junctions were ultra-structurally broadened in the chronic unpredictable stress (CUS) rat model of depression, while ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Huiqin Wang Xueying Yang Huaqing Lai Yang Sun Xu Yan Qidi Ai Meiyu Lin Songwei Yang Yantao Yang Shifeng Chu Zhenzhen Wang Naihong Chen Source Type: research
Ivy leaf dry extract EA 575 for the treatment of acute and chronic cough in pediatric patients: review and expert survey
CONCLUSIONS: EA 575 has minimal side effects in pediatric patients with cough, as demonstrated by large, real-world studies. EA 575 may provide clinical benefits in pediatric patients; however, more robust clinical trials are needed to confirm its efficacy.PMID:37731370 | DOI:10.1080/03007995.2023.2258777
Source: Current Medical Research and Opinion - September 21, 2023 Category: Research Authors: Georg Seifert Laura Upstone Christopher P Watling Christian Vogelberg Source Type: research
Prevalence, Awareness, and Control of Hypertensive Disorders amongst Pregnant Women Seeking Healthcare in Ghana
This study was conducted to find out the prevalence, awareness, risk factors, control, and the birth outcomes of HDPs. This was a retrospective cohort study conducted among pregnant women seeking care in selected health facilities in the Ashanti Region. Data on demographics, HDPs, and its associated birth outcomes were collected. Logistic regression models were used to examine the association of the independent variables with HDPs. The burden of HDPs was 37.2% among the 500 mothers enrolled with chronic hypertension superimposed with preeclampsia accounting for 17.6%, chronic hypertension, 10.2%, and preeclampsia 6.8% whil...
Source: Journal of Pregnancy - September 21, 2023 Category: OBGYN Authors: Pauline Boachie-Ansah Berko Panyin Anto Afia Frimpomaa Asare Marfo Edward Tieru Dassah Constance Caroline Cobbold Morrison Asiamah Source Type: research
Advances in Phytochemistry and Modern Pharmacology of Saposhnikovia Divaricata (Turcz.) Schischk
AbstractSaposhnikovia divaricata (Turcz.) Schischk (S. divaricata, Fangfeng) is a herb in theApiaceae family, and its root has been used since the Western Han Dynasty (202 B.C.). Chromones and coumarins are the pharmacologically active substances inS. divaricata. Modern phytochemical and pharmacological studies have demonstrated their antipyretic, analgesic, anti-inflammatory, antioxidant, anti-tumor, and anticoagulant activities. Technological and analytical strategy theory advancements have yielded novel results; however, most investigations have been limited to the main active substances —chromones and coumarins. Henc...
Source: Chinese Journal of Integrative Medicine - September 21, 2023 Category: Internal Medicine Source Type: research
Quality of Life and Use of Complementary and Alternative Medicines among Narcotics Anonymous Patients: A Cross-Sectional Study in Southeast Iran
CONCLUSION: Although there was no difference in quality of life between CAM and non-CAM users, the present study showed that prayer and medicinal herbs were the most commonly used methods among narcotics anonymous patients. However, prayer and religious beliefs were successful in improving the quality of life of these individuals. Physicians and other healthcare providers must advise patients with addiction to use different CAMs in order to improve their quality of life and quit narcotics. Future in-depth studies could help these patients use CAMs and improve their quality of life.PMID:37727769 | PMC:PMC10506870 | DOI:10.1155/2023/3003247
Source: Evidence-based Complementary and Alternative Medicine - September 20, 2023 Category: Complementary Medicine Authors: Mahlagha Dehghan Hemn Kaka Mirza Sobhan Alaeifar Moazemeh Jazinizadeh Mohammad Hossein Iranmanesh Fateme Mohammadiakbarabadi Mina Salehi Asma Ghonchehpour Mohammad Ali Zakeri Source Type: research
The Man Who Thinks He Can Live Forever
In a neat little neighborhood in Venice, Calif., there’s a block of squat, similar homes, filled with mortals spending their finite days on the planet eating pizza with friends, blowing out candles on birthday cakes, and binging late-night television. Halfway down the street, there’s a cavernous black modern box. This is where Bryan Johnson is working on what he calls “the most significant revolution in the history of Homo sapiens.”
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Johnson, 46, is a centimillionaire tech entrepreneur who has spent most of the last three years in pursuit of a si...
Source: TIME: Health - September 20, 2023 Category: Consumer Health News Authors: Charlotte Alter Tags: Uncategorized feature Source Type: news
