Alleviation of ultraviolet ‐B radiation‐induced photoaging using Saussurea medusa Maxim polysaccharide

Ultraviolet B radiation from sunlight can lead to photoaging, thickening of the dermis, and deep wrinkles. It triggers the production of inflammatory factors like TNF-a and IL-1, which then activate EGFR receptors in cells. This, in turn, activates MEK1/2 and ERK1/2, eventually causing an increase in the production of MMPs. The increased MMPs then degrade collagen and other extracellular matrix components, leading to skin inflammation and damage. However, the polysaccharides present inSaussurea medusa maxim can mitigate skin damage by this pathway. AbstractSaussureamedusa polysaccharide, the polysaccharide extract ofSaussurea medusa Maxim, a traditional Chinese herbal medicine, is used to combat intense ultraviolet radiation, cold, and hypoxia in patients, as well as during drought. This polysaccharide has rich medicinal and ecological values. We aimed to determine whethersaussureamedusa polysaccharides can reduce ultraviolet B (UVB)-induced skin photoaging. Seventy-five male Kunming mice were divided into five groups: control, UVB-only, UVB plus vitamin E (VE group), UVB plussaussurea medusa (2  g/kg), and UVB plussaussurea medusa (6  g/kg). The control group was irradiated with normal light, while the other four groups were subcutaneously administered 10 mL/kg/day D-galactose and irradiated with narrow-spectrum UVB for 40 min daily. From day 11, the VE group was administered 0.25 g/kg/day vitamin E, while thesaussurea medusa intervention groups were administered 2...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research