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Nutrition: Sodium
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Alterations of Bax/Bcl-2 ratio contribute to NaAsO < sub > 2 < /sub > induced thyrotoxicity in human thyroid follicular epithelial cells and SD rats
Ecotoxicol Environ Saf. 2023 Sep 6;264:115449. doi: 10.1016/j.ecoenv.2023.115449. Online ahead of print.ABSTRACTThe environmental toxicant arsenic causes various human diseases and threatens millions of people worldwide. Recently, a limited number of studies have revealed that exposure to arsenic is associated with thyroid dysfunction, indicating its toxicological impact on the thyroid gland, however, its precise forms of damage and underlying mechanisms remain largely unknown. Here, we sought to observe the thyrotoxicity of sodium arsenite (NaAsO2) on human thyroid follicular epithelial cells (Nthy-ori 3-1) and SD rats, a...
Source: Ecotoxicology and Environmental Safety - September 8, 2023 Category: Environmental Health Authors: Lili Fan Zhiqin He Lei Wang Huijie Gaoyang Dapeng Wang Peng Luo Source Type: research
A base-mediated synthesis of < em > N < /em > -hydroxy- and < em > N < /em > -alkoxyindoles from 2-nitrostyrenes
Tetrahedron. 2023 Sep 7;144:133578. doi: 10.1016/j.tet.2023.133578. Epub 2023 Aug 6.ABSTRACTSequential treatment of alkyl 2-(2-nitroaryl)-2-butenoates with potassium tert-butoxide and an electrophile, such as methyl iodide, benzyl bromide and allyl bromide, afforded N-alkoxyindoles. In related reactions, using sodium tert-pentoxide as the base with or without in situ addition of an electrophile afforded N-alkoxy- and N-hydroxyindoles, respectively. Electrophiles such as dimethylsulfate, p-tosyl chloride, and acetic anhydride afforded moderate yields of the respective N-methoxy-, N-tosyloxy, and N-acetoxyindoles, while meth...
Source: Tetrahedron - September 8, 2023 Category: Chemistry Authors: Blaine T McClay Katharine E Lambson Serge R Banini Tural N Akhmedov Bj örn C G Söderberg Source Type: research
More spice, less salt: How capsaicin affects liking for and perceived saltiness of foods in people with smell loss
Appetite. 2023 Sep 6:107032. doi: 10.1016/j.appet.2023.107032. Online ahead of print.ABSTRACTPeople who lose their sense of smell self-report consuming more salt to compensate for a lack of flavor and enhance eating enjoyment. However, this can contribute to excess sodium intake. Capsaicin may help increase salt taste intensity and eating enjoyment in people with smell loss, but this has not been studied in this population. The purpose of this study was to determine 1) whether salt intake in those with smell loss differs from population averages, 2) whether capsaicin increases flavor and salt taste intensity, and 3) if add...
Source: Appetite - September 8, 2023 Category: Nutrition Authors: Stephanie R Hunter Candelaria Beatty Pamela H Dalton Source Type: research
Double layer spherical Nanoparticles with Hyaluronic Acid Coating to Enhance Oral Delivery of Exenatide in T2DM rats
Eur J Pharm Biopharm. 2023 Sep 6:S0939-6411(23)00236-9. doi: 10.1016/j.ejpb.2023.09.003. Online ahead of print.ABSTRACTSoybean phospholipid was used as an amphiphilic material to form reverse micelles (RMs) in medium glycerol monolinoleate (Maisine) with Exenatide (EXT.) encapsulated in the polar core formed by the hydrophilic part of phospholipid. Cremopher RH40 and caprylocaproyl macrogol-8 glycerides EP/caprylocaproyl polyoxyl-8 glycerides NF (Labrasol) were added as surfactants to prepare reverse micelle-self emulsifying drug delivery system (RMs-SEDDS). On this basis, oil in water (O/W) emulsion was further prepared. ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 8, 2023 Category: Drugs & Pharmacology Authors: Yiying Lu Linjie Wu Mengting Lin Xiaoyan Bao Haiqing Zhong Peng Ke Qi Dai Qiyao Yang Xinjiang Tang WenHong Xu DongHang Xu Min Han Source Type: research
Combined Effects of Fluoride and Dietary Seleno-L-Methionine at Environmentally Relevant Concentrations on Female Zebrafish (Danio rerio) Liver: Histopathological Damages, Oxidative Stress and Inflammation
In this study, female zebrafish (Danio rerio) were exposed to fluoride (80 mg/L sodium fluoride) and/or dietary selenomethionine (Se-Met) for 30, 60 and 90 days, the effects on the liver of zebrafish were investigated. The results indicated that an increase in fluoride burden, inhibited growth and impaired liver morphology were recorded after fluoride exposure. Furthermore, fluoride alone caused oxidative stress and inflammation in the liver, as reflected by the increase in ROS and MDA contents, the reduction of anti-oxidative enzymes, the altered immune related enzymes (ACP, AKP, LZM and MPO) and the expression of IL-6, I...
Source: Biological Trace Element Research - September 8, 2023 Category: Biology Authors: Xiulin Zhang Jinling Cao Jianjie Chen Guodong Wang Lijuan Li Xiaobing Wei Runxiao Zhang Source Type: research
Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction
CONCLUSIONS: Cardiac conduction does not correlate with extracellular resistance but is biphasically related to perinexal separation, providing evidence that the relationship between CV and extracellular volume is determined by ephaptic mechanisms under conditions of normal gap junctional coupling.PMID:37681314 | DOI:10.1161/CIRCRESAHA.123.322567
Source: Circulation Research - September 8, 2023 Category: Cardiology Authors: William P Adams Tristan B Raisch Yajun Zhao Rafael Davalos Sarah Barrett D Ryan King Chandra B Bain Katrina Colucci-Chang Grace A Blair Alexandra Hanlon Alicia Lozano Rengasayee Veeraraghavan Xiaoping Wan Isabelle Deschene James W Smyth Gregory S Hoeker R Source Type: research
Potential protective effects of the water-soluble Chinese propolis on experimental ulcerative colitis
CONCLUSION: WSP downregulates OS by enhancing the function of endogenous antioxidant enzymes like SOD and GSH-Px, that inhibit neutrophil activity, as well as diminish pro-inflammatory cytokines like TNF-ɑ, IL-6, and IL-9, along with mechanisms that attenuate intestinal inflammation in UC rat model.PMID:37679980 | PMC:PMC10465833 | DOI:10.19852/j.cnki.jtcm.20230727.002
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Zhou Hua L I Hui Wang Haihua Source Type: research
Extraction, characterization and controlled release application of pectin-like/chitosan hydrogels system loaded Ciprofloxacin
CONCLUSION: The novel pectin-chitosan hydrogels hold the potential to enhance the quality of life for numerous patients by minimizing the need for frequent intake of chronic medications.PMID:37680160 | DOI:10.2174/1567201821666230901153513
Source: Current Drug Delivery - September 8, 2023 Category: Drugs & Pharmacology Authors: Amer Rashid Hameed Zeineb Mzoughi Mariem Itaimi Dammak Fawzi Habeeb Jabrail Didier Le Cerf Hatem Majdoub Source Type: research
Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction
CONCLUSIONS: Cardiac conduction does not correlate with extracellular resistance but is biphasically related to perinexal separation, providing evidence that the relationship between CV and extracellular volume is determined by ephaptic mechanisms under conditions of normal gap junctional coupling.PMID:37681314 | DOI:10.1161/CIRCRESAHA.123.322567
Source: Circulation Research - September 8, 2023 Category: Cardiology Authors: William P Adams Tristan B Raisch Yajun Zhao Rafael Davalos Sarah Barrett D Ryan King Chandra B Bain Katrina Colucci-Chang Grace A Blair Alexandra Hanlon Alicia Lozano Rengasayee Veeraraghavan Xiaoping Wan Isabelle Deschene James W Smyth Gregory S Hoeker R Source Type: research
Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism
This study provides novel insights into the mechanism of BBR in treating UC.PMID:37683590 | DOI:10.1016/j.biopha.2023.115430
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 8, 2023 Category: Drugs & Pharmacology Authors: Xiongjie Sun Yu Zhang Gang Cheng Tianxiang Zhu Zhigang Zhang Lei Xiong Haiming Hu Hongtao Liu Source Type: research
Treatment of salt from hides curing stage by electrocoagulation for use in the pickling stage of the tanning industry
Environ Res. 2023 Sep 6:117095. doi: 10.1016/j.envres.2023.117095. Online ahead of print.ABSTRACTThe raw materials for the tanning industry, namely hides and skins, are preserved (curing stage) and carried with common salt, i.e., sodium chloride (NaCl). Proceeding to conversion into leather, pickling is a key stage of the tannery process, which entails high demand of water and salt. In this work, the salt-derived brine (SdB) generated from the curing of hides was treated by iron-driven electrocoagulation (EC), aiming at its later application in the pickling stage of the tanning industry, promoting a transition to zero wast...
Source: Environmental Research - September 8, 2023 Category: Environmental Health Authors: Luana Sarinho Pedro Carvalho Diana Patoilo Jo ão Peres Ribeiro Jos é Baião da Cruz Joaquim Gai ão Catarina Marques Maria Isabel Nunes Source Type: research
A base-mediated synthesis of < em > N < /em > -hydroxy- and < em > N < /em > -alkoxyindoles from 2-nitrostyrenes
Tetrahedron. 2023 Sep 7;144:133578. doi: 10.1016/j.tet.2023.133578. Epub 2023 Aug 6.ABSTRACTSequential treatment of alkyl 2-(2-nitroaryl)-2-butenoates with potassium tert-butoxide and an electrophile, such as methyl iodide, benzyl bromide and allyl bromide, afforded N-alkoxyindoles. In related reactions, using sodium tert-pentoxide as the base with or without in situ addition of an electrophile afforded N-alkoxy- and N-hydroxyindoles, respectively. Electrophiles such as dimethylsulfate, p-tosyl chloride, and acetic anhydride afforded moderate yields of the respective N-methoxy-, N-tosyloxy, and N-acetoxyindoles, while meth...
Source: Tetrahedron - September 8, 2023 Category: Chemistry Authors: Blaine T McClay Katharine E Lambson Serge R Banini Tural N Akhmedov Bj örn C G Söderberg Source Type: research
Potential protective effects of the water-soluble Chinese propolis on experimental ulcerative colitis
CONCLUSION: WSP downregulates OS by enhancing the function of endogenous antioxidant enzymes like SOD and GSH-Px, that inhibit neutrophil activity, as well as diminish pro-inflammatory cytokines like TNF-ɑ, IL-6, and IL-9, along with mechanisms that attenuate intestinal inflammation in UC rat model.PMID:37679980 | PMC:PMC10465833 | DOI:10.19852/j.cnki.jtcm.20230727.002
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Zhou Hua L I Hui Wang Haihua Source Type: research
