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Nutrition: Iron

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Efficacy and Safety of Iron Chelation Therapy After Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Thalassemia Patients: A Retrospective Observational Study
In this study, we present the outcomes of our patients who received posttransplant oral chelation therapy. Patients and Methods: This retrospective observational study evaluated the outcomes of pediatric patients with thalassemia major who used oral chelation therapy after allogeneic HSCT at the Akdeniz University Pediatric Bone Marrow Unit between January 2008 and October 2019. Results: Deferasirox therapy was initiated in 58 pediatric patients who underwent HSCT for thalassemia. Pretreatment mean serum ferritin was 2166±1038 ng/mL. Treatment was initiated at a mean of 12±6.7 months after transplantation...
Source: Journal of Pediatric Hematology Oncology - January 1, 2022 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

The Paradigm Shift from Polycythemia to Anemia in COPD: The Critical Role of the Renin-Angiotensin System Inhibitors
Expert Rev Respir Med. 2022 Feb 25. doi: 10.1080/17476348.2022.2045958. Online ahead of print.ABSTRACTINTRODUCTION: Although polycythemia has been considered a common adverse event in COPD, anemia is reported more often and has gained more importance than polycythemia over the last thirty years.AREAS COVERED: Factors considered to be associated with the development of anemia in COPD have included: Aging and kidney dysfunction with erythropoietin deficiency and bone marrow suppression due to uremic toxins; heart failure (HF), which is often encountered in COPD and is accompanied by anemia in one third of the cases; Low-grad...
Source: Respiratory Care - February 25, 2022 Category: Respiratory Medicine Authors: Vassilios Vlahakos Katerina Marathias Sofia Lionaki Stelios Loukides Spyros Zakynthinos Demetrios Vlahakos Source Type: research

A Yersiniabactin-producing Klebsiella aerogenes Strain Causing an Outbreak in an Austrian Neonatal Intensive Care Unit
Conclusion: This is the first report of an outbreak of a yersiniabactin-producing K. aerogenes strain causing invasive infection in preterm infants. We hypothesize that, due to improved iron uptake, this strain was associated with higher virulence than non-yersiniabactin-producing strains. Extended search for virulence factors and genetic sequencing could be pivotal in the management of NICU outbreaks in the future.
Source: The Pediatric Infectious Disease Journal - June 13, 2022 Category: Infectious Diseases Tags: Maternal-Neonatal Reports Source Type: research

Iron as a catalyst of human low-density lipoprotein oxidation: Critical factors involved in its oxidant properties
Publication date: Available online 20 February 2017 Source:Journal of Trace Elements in Medicine and Biology Author(s): Domenico Lapenna, Giuliano Ciofani, Gabriele Obletter Iron-induced human LDL oxidation, which is relevant to atherosclerosis, has not yet been properly investigated. We addressed such issue using iron(II) and (III) basically in the presence of phosphates, which are present in vivo and influence iron oxidative properties, at pH 4.5 and 7.4, representative, respectively, of the lysosomal and plasma environment. In 10mM phosphate buffered saline (PBS), iron(II) induces substantial LDL oxidation at pH 4.5 at...
Source: Journal of Trace Elements in Medicine and Biology - February 20, 2017 Category: Biochemistry Source Type: research

Pediatric gastric ganglioneuroma presenting as anemia
In this report, we describe a 12-year-old female who presented with iron deficiency anemia and melena. Endoscopy was performed to elucidate the source of her symptoms, and revealed a gastric mass with overlying ulceration. Following resection and pathologic examination, the mass was diagnosed as a solitary polypoid ganglioneuroma. A solitary polypoid ganglioneuroma is an uncommon, benign tumor of neural crest cell origin. They are most often asymptomatic and found incidentally, but can present with rectal bleeding, obstruction, pain, and changes in bowel function. Complete resection is the therapy of choice to prevent prog...
Source: Journal of Pediatric Surgery Case Reports - December 16, 2017 Category: Surgery Source Type: research

Pediatric Collagenous Gastritis and Colitis: A Case Series and Review of the Literature
Conclusions: Collagenous gastritis is a rare condition in children. A small proportion of children develop features of the “‘adult” phenotype at a very young age. Patients with collagenous gastritis require long-term follow-up and monitoring of their disease. Further randomized clinical trials are needed to establish an effective therapeutic strategy.
Source: Journal of Pediatric Gastroenterology and Nutrition - August 23, 2018 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Pharmacokinetics of ferric pyrophosphate citrate administered via dialysate and intravenously to pediatric patients on chronic hemodialysis
ConclusionsFPC iron can be administered to pediatric patients with CKD-5HD via dialysate or by the IV route. Further study of FPC administered to maintain hemoglobin concentration is indicated.
Source: Pediatric Nephrology - September 18, 2018 Category: Urology & Nephrology Source Type: research

Blood Loss Due to Laboratory Testing in Critical Care Patients: A Retrospective Cohort Study
Conclusions: Anemia and RBC transfusions are frequent in ICU patients with two-thirds of patients developing severe anemia (hemoglobin <9.0 g/dL) and 47.5% receiving RBC transfusion, respectively. Our results suggest that blood loss for laboratory testing remains substantial in contemporary medical-surgical ICU patients and is associated with the need for RBC transfusion. Strategies to reduce blood loss from laboratory testing represent an area for further prospective investigation.DisclosuresSiegal: BMS-Pfizer: Honoraria; Bayer: Honoraria; Portola Pharmaceuticals: Honoraria.
Source: Blood - November 21, 2018 Category: Hematology Authors: James, T. E., Barty, R., Liu, Y., Rochwerg, B., Heddle, N., Siegal, D. M. Tags: 101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron Source Type: research

Sickle cell diseases: What can nuclear medicine offer?
Authors: Niccoli Asabella A, Altini C, Nappi AG, Lavelli V, Ferrari C, Marzullo A, Loiodice A, Rubini G Abstract Sickle cell disease (SCD) is the best known haemoglobinopathy, caused by a mutation substituting valina for glutamic acid at position 6 of the beta-globin chain of adult hemoglobin A, resulting in hemoglobin S (HbS). The homozygous HbS disease (HbSS), an autosomal recessive disorder, is the most common form and the Mediterranean area, along with sub-Saharian African and India, have the highest prevalence (1%-15%). In particular, Sicily with a prevalence of 2%-5%, is among the most interested regions. How...
Source: Hellenic Journal of Nuclear Medicine - March 9, 2019 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Brazilian preschool children attending day care centers show an inadequate micronutrient intake through 24-hour duplicate diet
Publication date: Available online 30 April 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Isabelle Nogueira Leroux, Ana Paula Sacone da Silva Ferreira, Fernanda Pollo Paniz, Fábio Ferreira da Silva, Maciel Santos Luz, Bruno Lemos Batista, Dirce Maria Marchioni, Kelly Polido Kaneshiro OlympioAbstractInadequate micronutrient intake in childhood harms growth and development, and it is related to increased rates of morbidity and mortality. The aim of this study is to evaluate the dietary intake and prevalence of inadequate micronutrient intake in preschool children (1–4 years old) attending two-day...
Source: Journal of Trace Elements in Medicine and Biology - May 1, 2019 Category: Biochemistry Source Type: research

Insights Into Pediatric Autoimmune Gastritis: Is There a Role for: Helicobacter pylori: Infection?
Conclusions: Our findings highlight that AIG may have an age-dependent presentation; thus, we can consider a pediatric phenotype that in contrast to adults, is manifested by refractory iron-deficient anemia and associated with parietal cell autoantibody positivity, but not intrinsic factor autoantibodies. A correlation between H pylori and AIG was not evident in the current study and it is still unclear whether H pylori is a trigger for AIG.
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Vegan diet in children and adolescents. Recommendations from the French-speaking Pediatric Hepatology, Gastroenterology and Nutrition Group (GFHGNP).
Abstract The current craze for vegan diets has an effect on the pediatric population. This type of diet, which does not provide all the micronutrient requirements, exposes children to nutritional deficiencies. These can have serious consequences, especially when this diet is introduced at an early age, a period of significant growth and neurological development. Even if deficiencies have less impact on older children and adolescents, they are not uncommon and consequently should also be prevented. Regular dietary monitoring is essential, vitamin B12 and vitamin D supplementation is always necessary, while iron, ca...
Source: Archives de Pediatrie - October 11, 2019 Category: Pediatrics Authors: Lemale J, Mas E, Jung C, Bellaiche M, Tounian P, French-speaking Pediatric Hepatology, Gastroenterology and Nutrition Group (GFHGNP) Tags: Arch Pediatr Source Type: research

Comparison of liver T1 relaxation times without and with iron correction in pediatric autoimmune liver disease
ConclusionThere is excellent positive correlation between liver native T1 and cT1 measurements in pediatric patients with autoimmune liver disease. This relationship brings into question the need to perform T1 iron correction in this patient population. T1 and cT1 measurements are not interchangeable, however, due to considerable systematic bias with cT1 values being considerably higher.
Source: Pediatric Radiology - May 13, 2020 Category: Radiology Source Type: research

Hypoferritinemia and iron deficiency in youth with pediatric acute-onset neuropsychiatric syndrome.
CONCLUSION: Hypoferritinemia and iron deficiency appear to be more common in PANS patients. More research is needed to confirm and understand this association. IMPACT: Our study suggests hypoferritinemia and iron deficiency are more common in patients with pediatric acute-onset neuropsychiatric syndrome (PANS) than in the sex- and age-matched US population.Hypoferritinemia was commonly observed during a disease flare but not associated with dietary or demographic factors. In patients with PANS and iron deficiency, clinicians should consider possibility of inflammation as the cause especially if iron deficiency cannot ...
Source: Pediatric Research - August 2, 2020 Category: Pediatrics Authors: Chan A, Karpel H, Spartz E, Willett T, Farhadian B, Jeng M, Thienemann M, Frankovich J Tags: Pediatr Res Source Type: research