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Feasibility and acceptability of miracle fruit application prior to the consumption of sour-tasting foods as a weight-loss strategy in adults with diabetes or prediabetes: A randomized crossover trial
Appetite. 2023 Sep 17:107046. doi: 10.1016/j.appet.2023.107046. Online ahead of print.ABSTRACTMiracle fruit (MF) has emerged as a promising option for healthy noncaloric sweeteners due to its sour-to-sweet taste-modifying effects and high antioxidant activity. We aimed to examine the feasibility and acceptability of using MF as a weight-loss strategy for individuals with diabetes or prediabetes. Fifty Korean-American men and women (25 participants each) aged 45-75 years with diabetes or prediabetes were recruited in this study. They participated in a randomized placebo-controlled crossover trial where they took the assigne...
Source: Appetite - September 19, 2023 Category: Nutrition Authors: Sung Eun Choi Taehwan Park Source Type: research

Effects of long-term consumption of two plant-based dietary supplements on cardiovascular health and low-grade inflammation in middle-aged and elderly people: study protocol for a randomised, controlled trial
This study will provide evidence whether long-term, plant-based dietary supplementation can support cardiovascular health, anti-inflammatory processes, immunity and nutritional status in ageing. Trial registration This trial was registered at ClinicalTrials.gov (NCT04763291) on February 21, 2021.PMID:37726820 | PMC:PMC10510179 | DOI:10.1186/s41043-023-00434-x
Source: Journal of Health, Population, and Nutrition - September 19, 2023 Category: International Medicine & Public Health Authors: Melina Tsiountsioura Gerhard Cvirn Lisa Meixner-Goetz Tobias Ziegler Manfred Lamprecht Source Type: research

Human health risk assessment based on direct and indirect exposure to endocrine disrupting herbicides in drinking, ground, and surface water in Croatia
The objective of this study was to assess the possible human health risks associated with terbuthylazine and endocrine-disrupting herbicides atrazine, acetochlor, and metolachlor in the drinking, surface, and groundwater of the Zagreb city region, Croatia. We relied on advanced statistical methods and principal component analysis (PCA), which revealed higher levels of atrazine and acetochlor in drinking and groundwater samples and higher presence of metolachlor and terbuthylazine in surface waters. To evaluate the danger to human health, various exposure scenarios have been assessed. The risk of direct human exposure to an...
Source: Environmental Science and Pollution Research International - September 19, 2023 Category: Environmental Health Authors: Gordana Menda š Tijana Mili ćević Sanja Fingler Vlasta Drevenkar Snje žana Herceg Romanić Aleksandar Popovi ć Dubravka Reli ć Source Type: research

Postsecondary Students' Knowledge of and Adherence to the 2019 Canada's Food Guide: A Cross-sectional Pilot Survey
Conclusions: Although half of the participants correctly answered all 8 questions that assessed knowledge of the CFG, there is an opportunity for dietitians and related health professionals to improve engagement with CFG.PMID:37725514 | DOI:10.3148/cjdpr-2023-008
Source: Canadian Journal of Dietetic Practice and Research - September 19, 2023 Category: Nutrition Authors: Heather J Zhao Rosain Stennett Sharon I Kirkpatrick Russell J de Souza Source Type: research

The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum
Fungal Genet Biol. 2023 Sep 16:103837. doi: 10.1016/j.fgb.2023.103837. Online ahead of print.ABSTRACTEpigenetic modification of chromosome structure has increasingly been associated with alterations in secondary metabolism and sporulation defects in filamentous fungal pathogens. Recently, the epigenetic reader protein SntB was shown to govern virulence, spore production and mycotoxin synthesis in the fruit pathogen Penicillium expansum. Through immunoprecipitation-coupled mass spectrometry, we found that SntB is a member of a protein complex with KdmB, a histone demethylase and the essential protein RpdA, a histone deacety...
Source: Fungal Genetics and Biology - September 18, 2023 Category: Biology Authors: Dianiris Luciano-Rosario Omer Barda Joanna Tannous Dean Frawley Özgür Bayram Dov Prusky Edward Sionov Nancy P Keller Source Type: research

Structural variations of lignin and lignin-carbohydrate complexes from the fruit shells of Camellia oleifera during ripening
Int J Biol Macromol. 2023 Sep 16:126946. doi: 10.1016/j.ijbiomac.2023.126946. Online ahead of print.ABSTRACTCamellia oleifera fruit shell (CFS), a waste lignocellulosic biomass resulting from Camellia oleifera oil production industry, is abundantly available in Southern China. Herein, to understand the structural variations of CFS lignins and lignin-carbohydrate complexes (LCC) during ripening, the native lignin and LCC fractions from CFS (harvested every seven days from October 1 to 30, 2022) were isolated and characterized systematically. The molecular weights of both MWL and DEL fractions steadily increased during ripen...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xichuang Cheng Ruxia Ning Pengfei Li Fenglun Zhang Kun Wang Jianxin Jiang Source Type: research

Integrating Chemical Profiling, In Vivo Study, and Network Pharmacology to Explore the Anti-inflammatory Effect of < em > Pterocarpus dalbergioides < /em > Fruits and Its Correlation with the Major Phytoconstituents
ACS Omega. 2023 Aug 29;8(36):32544-32554. doi: 10.1021/acsomega.3c02940. eCollection 2023 Sep 12.ABSTRACTThe purpose of this study is to explore the anti-inflammatory activity of Pterocarpus dalbergioides fruit extract (PFE) and the underlying mechanism. Chemical profiling using ultraperformance liquid chromatography/mass spectrometry identified 28 compounds in PFE (12 flavonoids, 5 fatty acids, 4 phenolic compounds, 3 alkaloids, 2 sesquiterpenes, and 2 xanthophylls). PFE (2 g/kg) significantly inhibited carrageenan-induced rat paw edema after 4 h of administration (42% inhibition). A network-based strategy and molecular d...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Taghreed S Alnusaire Ibrahim Lahbib Sabouni Hanan Khojah Sumera Qasim Mohammad M Al-Sanea Sadaf Siddique Fatma Alzahraa Mokhtar Shaimaa R Ahmed Source Type: research

Analyzing the Potential Impacts of Three Interventions on Fruit and Vegetable Consumption in Urban Kenya Using Participatory Systems Modeling
CONCLUSIONS: The combination of Group Model Building and simulation modeling informed intervention priorities for an important public health nutrition issue.PMID:37721018 | DOI:10.1017/S1368980023002033
Source: Public Health Nutrition - September 18, 2023 Category: International Medicine & Public Health Authors: Charles F Nicholson Eva Monterrosa Source Type: research

Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research

Structural variations of lignin and lignin-carbohydrate complexes from the fruit shells of Camellia oleifera during ripening
Int J Biol Macromol. 2023 Sep 16:126946. doi: 10.1016/j.ijbiomac.2023.126946. Online ahead of print.ABSTRACTCamellia oleifera fruit shell (CFS), a waste lignocellulosic biomass resulting from Camellia oleifera oil production industry, is abundantly available in Southern China. Herein, to understand the structural variations of CFS lignins and lignin-carbohydrate complexes (LCC) during ripening, the native lignin and LCC fractions from CFS (harvested every seven days from October 1 to 30, 2022) were isolated and characterized systematically. The molecular weights of both MWL and DEL fractions steadily increased during ripen...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xichuang Cheng Ruxia Ning Pengfei Li Fenglun Zhang Kun Wang Jianxin Jiang Source Type: research

Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Brain Research - September 18, 2023 Category: Neurology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research

Integrating Chemical Profiling, In Vivo Study, and Network Pharmacology to Explore the Anti-inflammatory Effect of < em > Pterocarpus dalbergioides < /em > Fruits and Its Correlation with the Major Phytoconstituents
ACS Omega. 2023 Aug 29;8(36):32544-32554. doi: 10.1021/acsomega.3c02940. eCollection 2023 Sep 12.ABSTRACTThe purpose of this study is to explore the anti-inflammatory activity of Pterocarpus dalbergioides fruit extract (PFE) and the underlying mechanism. Chemical profiling using ultraperformance liquid chromatography/mass spectrometry identified 28 compounds in PFE (12 flavonoids, 5 fatty acids, 4 phenolic compounds, 3 alkaloids, 2 sesquiterpenes, and 2 xanthophylls). PFE (2 g/kg) significantly inhibited carrageenan-induced rat paw edema after 4 h of administration (42% inhibition). A network-based strategy and molecular d...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Taghreed S Alnusaire Ibrahim Lahbib Sabouni Hanan Khojah Sumera Qasim Mohammad M Al-Sanea Sadaf Siddique Fatma Alzahraa Mokhtar Shaimaa R Ahmed Source Type: research

Analyzing the Potential Impacts of Three Interventions on Fruit and Vegetable Consumption in Urban Kenya Using Participatory Systems Modeling
CONCLUSIONS: The combination of Group Model Building and simulation modeling informed intervention priorities for an important public health nutrition issue.PMID:37721018 | DOI:10.1017/S1368980023002033
Source: Public Health Nutrition - September 18, 2023 Category: International Medicine & Public Health Authors: Charles F Nicholson Eva Monterrosa Source Type: research

The histone demethylase KdmB is part of a trimeric protein complex and mediates virulence and mycotoxin production in Penicillium expansum
Fungal Genet Biol. 2023 Sep 16:103837. doi: 10.1016/j.fgb.2023.103837. Online ahead of print.ABSTRACTEpigenetic modification of chromosome structure has increasingly been associated with alterations in secondary metabolism and sporulation defects in filamentous fungal pathogens. Recently, the epigenetic reader protein SntB was shown to govern virulence, spore production and mycotoxin synthesis in the fruit pathogen Penicillium expansum. Through immunoprecipitation-coupled mass spectrometry, we found that SntB is a member of a protein complex with KdmB, a histone demethylase and the essential protein RpdA, a histone deacety...
Source: Fungal Genetics and Biology - September 18, 2023 Category: Biology Authors: Dianiris Luciano-Rosario Omer Barda Joanna Tannous Dean Frawley Özgür Bayram Dov Prusky Edward Sionov Nancy P Keller Source Type: research

Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Brain Research - September 18, 2023 Category: Neurology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research