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Nutrition: Diets
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Tumor lipid metabolism: a mechanistic link between diet and cancer progression
Curr Opin Biotechnol. 2023 Sep 13;84:102993. doi: 10.1016/j.copbio.2023.102993. Online ahead of print.ABSTRACTThe potential for 'anti-cancer' diets to markedly alter cancer risk and prognosis has captured the imagination of patients, physicians, and researchers alike, but many of these dietary recommendations come from correlative studies that attribute certain diets to altered cancer risk. While provocative, little is known about the molecular mechanisms behind how these dietary interventions impact cancer progression. Within this context, however, changes in tumor lipid metabolism are emerging as a key contributor. In th...
Source: Current Opinion in Biotechnology - September 16, 2023 Category: Biotechnology Authors: Yu-Jin Jeong Thomas J Rogers Carolyn E Anderson Evan C Lien Source Type: research
Mandibular glands secrete 24-methylenecholesterol into honey bee (Apis mellifera) food jelly
Insect Biochem Mol Biol. 2023 Sep 14:104011. doi: 10.1016/j.ibmb.2023.104011. Online ahead of print.ABSTRACTHoney bee (Apis mellifera) workers feed their larvae with food jelly that is secreted by specialized glands in their heads - the hypopharyngeal and the mandibular glands. Food jelly contains all the nutrients the larvae need to develop into adult honey bees, including essential dietary sterols. The main sterol in food jelly, 24-methylenecholesterol (24 MC), is pollen-derived and delivered in food jelly to the larvae in a complex with two proteins, major royal jelly protein 1 (MRJP1) and apisim. Whereas the proteins a...
Source: Insect Biochemistry and Molecular Biology - September 16, 2023 Category: Biochemistry Authors: Anja Buttstedt Christian W W Pirk Abdullahi A Yusuf Source Type: research
Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice
Amino Acids. 2023 Sep 16. doi: 10.1007/s00726-023-03332-y. Online ahead of print.ABSTRACTAbnormal fat accumulation, enhanced free fatty acids (FFA) release, and their metabolites cause insulin resistance (IR) in major glucose-lipid metabolic organs such as skeletal muscle and adipose tissue. However, excessive lipolysis and FFA release from adipose tissue elevate plasma FFA levels leading to oxidative stress and skeletal muscle IR. Indeed, in obese individuals, there is enhanced pro-inflammatory secretion from adipose tissue influencing insulin signaling in skeletal muscles. Here, we investigated the effect of PSTi8 on FFA...
Source: Amino Acids - September 16, 2023 Category: Biochemistry Authors: Richa Garg Arun Agarwal Roshan Katekar Umesh Kumar Goand Naveen Singh Shubhi Yadav Shivam Rathaur Saurabh Verma Debalina Maity Sachin Vishwakarma Jiaur R Gayen Source Type: research
Tumor lipid metabolism: a mechanistic link between diet and cancer progression
Curr Opin Biotechnol. 2023 Sep 13;84:102993. doi: 10.1016/j.copbio.2023.102993. Online ahead of print.ABSTRACTThe potential for 'anti-cancer' diets to markedly alter cancer risk and prognosis has captured the imagination of patients, physicians, and researchers alike, but many of these dietary recommendations come from correlative studies that attribute certain diets to altered cancer risk. While provocative, little is known about the molecular mechanisms behind how these dietary interventions impact cancer progression. Within this context, however, changes in tumor lipid metabolism are emerging as a key contributor. In th...
Source: Current Opinion in Biotechnology - September 16, 2023 Category: Biotechnology Authors: Yu-Jin Jeong Thomas J Rogers Carolyn E Anderson Evan C Lien Source Type: research
Mandibular glands secrete 24-methylenecholesterol into honey bee (Apis mellifera) food jelly
Insect Biochem Mol Biol. 2023 Sep 14;161:104011. doi: 10.1016/j.ibmb.2023.104011. Online ahead of print.ABSTRACTHoney bee (Apis mellifera) workers feed their larvae with food jelly that is secreted by specialized glands in their heads - the hypopharyngeal and the mandibular glands. Food jelly contains all the nutrients the larvae need to develop into adult honey bees, including essential dietary sterols. The main sterol in food jelly, 24-methylenecholesterol (24MC), is pollen-derived and delivered in food jelly to the larvae in a complex with two proteins, major royal jelly protein 1 (MRJP1) and apisim. Whereas the protein...
Source: Insect Biochemistry and Molecular Biology - September 16, 2023 Category: Biochemistry Authors: Anja Buttstedt Christian W W Pirk Abdullahi A Yusuf Source Type: research
Sports Nutrition Knowledge Questionnaires Developed for the Athletic Population: a Systematic Review
AbstractPurpose of ReviewSports nutrition (SN) is pivotal in aiding athletes to reach peak performance, minimize sport-related injuries, enhance career longevity, and improve general health. An accurate assessment of athletes ’ sports nutrition knowledge (SNK) is required to design targeted nutrition education programs aimed at enhancing both nutritional knowledge and dietary practices. This review systematically evaluates studies that use questionnaires to assess the SNK of athletes engaged in athletics.Recent FindingsThe literature search was conducted in PubMed®, Web of Science®, and Scopus®, and 375 potentially re...
Source: Current Nutrition Reports - September 16, 2023 Category: Nutrition Source Type: research
Promoting plant-based eating in meat-centric meal contexts: a field study
CONCLUSIONS: A short-term, theory-driven, operationally feasible intervention was effective in promoting increased plant-based meal choices in a collective meal context. Nevertheless, these changes were not entirely sustained over time. Future studies could test whether prolonged or more transformative interventions are necessary to unlock entrenched food practices more effectively in meat-centric collective meal contexts.PMID:37712383 | DOI:10.1017/S1368980023001763
Source: Public Health Nutrition - September 15, 2023 Category: International Medicine & Public Health Authors: David Guedes Vasco Braz ão Lisa Roque L úcia Campos Cristina Godinho Monica Truninger Markus Vinnari Jo ão Graça Source Type: research
Boosting thermophilic anaerobic digestion with conductive materials: Current outlook and future prospects
Chemosphere. 2023 Sep 13:140175. doi: 10.1016/j.chemosphere.2023.140175. Online ahead of print.ABSTRACTThermophilic anaerobic digestion (TAD) can provide superior process kinetics, higher methane yields, and more pathogen destruction than mesophilic anaerobic digestion (MAD). However, the broader application of TAD is still very limited, mainly due to process instabilities such as the accumulation of volatile fatty acids and ammonia inhibition in the digesters. An emerging technique to overcome the process disturbances in TAD and enhance the methane production rate is to add conductive materials (CMs) to the digester. Rece...
Source: Chemosphere - September 15, 2023 Category: Chemistry Authors: Monisha Alam Bipro Ranjan Dhar Source Type: research
Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex
This study was conducted to assess the neurotoxic and neuroprotective effects of these two dietary components in the rat cerebral cortex. Twenty-four Sprague Dawley rats were divided into 4 equal groups and were treated with MSG (2 g/kg) and TA (50 mg/kg) alone and in combination for 3 weeks. Alterations in oxidative stress indicators (MDA and GSH) were measured in the cortex tissues. In addition, changes in enzymatic activities and gene expression patterns of antioxidant system components (GST, GPx, CAT, and SOD) were investigated. Furthermore, mRNA expressions of FoxO transcription factors (Foxo1 and Foxo3) and apoptotic...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Medine Sibel Karagac Hamid Ceylan Source Type: research
Intratumoral Bacteria as Mediators of Cancer Immunotherapy Response
Cancer Res. 2023 Sep 15;83(18):2985-2986. doi: 10.1158/0008-5472.CAN-23-1857.ABSTRACTMultiple lines of evidence spanning from animal models to human clinical trials indicate that the microbiome influences cancer immunotherapy response. Whereas initial studies focused exclusively on the gastrointestinal (gut) microbiota-tumor axis, more recent studies have examined the possibility that bacteria located within tumor cells or within the tumor microenvironment mediate cancer treatment response. Strikingly, this phenomenon has been demonstrated in cancers that arise in anatomic locations that are traditionally thought to be dev...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Karen S Sfanos Source Type: research
Global burden of early-onset colorectal cancer among people aged 40-49 years from 1990 to 2019 and predictions to 2030
CONCLUSION: The current and future burden of EO-CRC among people aged 40-49 years is heavy. Substantial variation exists in disease burden across regions and countries. Urgent screening actions and policies are needed.PMID:37712957 | DOI:10.1007/s00432-023-05395-6
Source: Clinical Colorectal Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Xiaowei Tang Jieyu Peng Shu Huang Huan Xu Ping Wang Jiao Jiang Wei Zhang Xiaomin Shi Lei Shi Xiaolin Zhong Muhan L ü Source Type: research
A transcriptomic study of osteoporosis induced by ketogenic diet in mice
CONCLUSION: The differentially expressed genes and enriched pathways identified in the mouse models provide new clues for studying the molecular mechanism and prevention of KD-induced osteoporosis.PMID:37712283 | DOI:10.12122/j.issn.1673-4254.2023.08.23
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Wu Y Fan Y Ye P Li Q Zhu Z Chen B Li W Wang L Zheng Source Type: research
Energy expenditure deficits drive obesity in a mouse model of Alstr öm syndrome
CONCLUSIONS: Either loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.PMID:37712194 | DOI:10.1002/oby.23877
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Erin J Stephenson Clint E Kinney Amanda S Stayton Joan C Han Source Type: research
< em > Erchen < /em > Decoction improves iron homeostasis in mice with non-alcoholic fatty liver disease by regulating iron transport capacity in the spleen
CONCLUSION: Erchen Decoction can alleviate high-fat diet-induced iron metabolism disorder by improving the iron ion transport ability of the spleen cells to delay the progression of NAFLD.PMID:37712264 | DOI:10.12122/j.issn.1673-4254.2023.08.04
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: G Deng H Jia Y Li J Li C Wu H Shi M Qin J Zhao C Liu Y Liao L Gao Source Type: research
Lead, Cadmium, and Arsenic in Raw Milk Produced in the Vicinity of a Mini Mineral Concentrator in the Central Andes and Health Risk
This study evaluated the potential risk to human health from lead (Pb), cadmium (Cd), and arsenic (As) from the consumption of milk produced in an area of the Central Andes valley near a mini mineral concentrator by estimating the weekly intake (WI), dietary risk quotient (DRC), hazard quotient (THQ), and hazard index (HI) for the Peruvian population aged 2 to 85 years, in three scenarios of milk consumption by age (minimum, average, and maximum). Toxic element quantification was performed by flame atomic absorption spectrometry following standardized procedures. The mean amount ± standard deviation of Pb, Cd, and As in s...
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Doris Chirinos-Peinado Jorge Castro-Bedri ñana Elva R íos-Ríos Gianfranco Castro-Chirinos Yubaly Quispe-Poma Source Type: research
