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Nutrition: Antidoxidants
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Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease
In conclusion, our study indicates that AST had a strong protective effect on PQ-induced oxidative stress and antagonized apoptotic cell death in SH-SY5Y cells and PQ-induced mice PD model, which might provide new insights of AST for PD treatment.PMID:37708917 | DOI:10.1016/j.brainresbull.2023.110762
Source: Brain Research - September 14, 2023 Category: Neurology Authors: Lei Wang Kunliang Lu Xingyue Lou Shenghui Zhang Wenxin Song Ranran Li Lujing Geng Binfeng Cheng Source Type: research
Can the Herbicide Dicamba Produce Oxidative Stress in the Native South American fish Jenynsia lineata at Environmentally Relevant Concentrations?
Bull Environ Contam Toxicol. 2023 Sep 14;111(3):41. doi: 10.1007/s00128-023-03796-4.ABSTRACTDicamba (DIC) is one of the most applied auxin herbicides worldwide. Sublethal effects in the South American native fish Jenynsia lineata exposed to DIC concentrations close to environmental concentrations (0.03-30 µg/L) during 48 h were analysed thorough the evaluation of catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD) activities and malondialdehyde (MDA) and H2O2 levels for detecting potential oxidative stress. In gills MDA increased showing oxidative damage probably because of an inefficient antioxida...
Source: Bulletin of Environmental Contamination and Toxicology - September 14, 2023 Category: Environmental Health Authors: Diana M Villagran Lucas R Lombardero Andrea C Crupkin Julieta R Mendieta Sandra K Medici Francisco Lavarello M Fernanda Simoniello Mirta L Menone Source Type: research
Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease
In conclusion, our study indicates that AST had a strong protective effect on PQ-induced oxidative stress and antagonized apoptotic cell death in SH-SY5Y cells and PQ-induced mice PD model, which might provide new insights of AST for PD treatment.PMID:37708917 | DOI:10.1016/j.brainresbull.2023.110762
Source: Brain Research Bulletin - September 14, 2023 Category: Neurology Authors: Lei Wang Kunliang Lu Xingyue Lou Shenghui Zhang Wenxin Song Ranran Li Lujing Geng Binfeng Cheng Source Type: research
Nose-to-Brain Delivery of Hesperidin Nanoparticles Loaded In-Situ Gel for Neuroprotective Action
CONCLUSION: This study showed the potential of HSP NPs to be an effective neuroprotective agent.PMID:37708993 | DOI:10.1016/j.pharma.2023.09.001
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Suraj Bamankar Vaishali Londhe Source Type: research
Anti-inflammatory effect of < em > Lactiplantibacillus plantarum < /em > T1 cell-free supernatants through suppression of oxidative stress and NF- κB- and MAPK-signaling pathways
This study showed the excellent antioxidant and anti-inflammatory properties of L. plantarum T1 through multiple pathways, highlighting its potential for further research and application as a probiotic strain. IMPORTANCE L. plantarum T1 stood out in a series of acid and bile salt tolerance and bacterial inhibition tests as a probiotic isolated from paocai, which provides many health benefits to the host by inhibiting the growth of harmful pathogenic microorganisms and suppressing excessive levels of oxidative stress and inflammation. Not all LAB have good probiotic functions and are used in various applications. The anti-i...
Source: Applied and Environmental Microbiology - September 13, 2023 Category: Microbiology Authors: Rui Hao Qianqian Liu Lu Wang Wenwen Jian Yu Cheng Qiuyue Zhang Kim Hayer Raja Kamarudin Raja Idris Yi Zhang He Lu Zeng Tu Source Type: research
In vitro establishment of cell suspension culture of Ceropegia bulbosa for improved production of cerpegin content through elicitation of engineered carbon and ZnO nanoparticles
Environ Sci Pollut Res Int. 2023 Sep 13. doi: 10.1007/s11356-023-29533-2. Online ahead of print.ABSTRACT The present investigations aimed to conserve C. bulbosa a threatened plant species and for production of cerpegin through cell culture technology using ENP elicitation. Leaf explants were aseptically cultured with normal MS medium-supplemented PGRs BA and NAA various concentrations, and the best callus induction response was recorded on 4.5 + 4.5 μM. The prospective special effects of the ENPs on plant cell cultures are the key part of our study and used to evaluate leaf callus culture proliferation with the reduction ...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Komal Kashyap Suman Parihar Gyan Singh Shekhawat Source Type: research
Oxidative stress in breast cancer after chemotherapy
Bioinformation. 2022 Dec 31;18(12):1141-1145. doi: 10.6026/973206300181141. eCollection 2022.ABSTRACTIt is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containin...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Tejaswi Pullakanam Sri Phani Murugan Mannangatti Ramakrishna Nekkala Venkata Madhavi Bellala Ravi Shankar Bellala Vijayalakshmi Payala Source Type: research
Oxidative stress associated with proteomic and fatty acid profiles of sperm from Nellore bulls at rest
Biol Reprod. 2023 Sep 13:ioad121. doi: 10.1093/biolre/ioad121. Online ahead of print.ABSTRACTSexual rest is a transient condition, that compromises conception rates, characterized by large volumes of ejaculate with high percentages of dead sperm observed in bulls. The biochemical mechanisms leading to this ejaculate pattern are not fully understood. Six adult resting Nellore bulls were submitted to Breeding Soundness Evaluation by four consecutive semen collections through the electroejaculation method during a 30 min period. Each ejaculate had its semen phenotypic parameters, morphology and physical aspects, evaluated. To...
Source: Biology of Reproduction - September 13, 2023 Category: Reproduction Medicine Authors: Camilo Jos é Ramírez-López Edvaldo Barros Pedro Marcus Vidigal Denise Okano Silva Lidiany Lopes Gomes Rener Philipe Rodrigues Carvalho Alex Gazolla Castro Maria Cristina Baracat-Pereira Simone Eliza Facioni Guimar ães Jos é Domingos Guimarães Source Type: research
Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice
Biol Trace Elem Res. 2023 Sep 13. doi: 10.1007/s12011-023-03845-3. Online ahead of print.ABSTRACTOverdose of acetaminophen (paracetamol), a widely used non-prescriptive analgesic and antipyretic medication, is one of the main causes of drug-induced acute liver failure around the world. Oxidative stress contributes to this hepatotoxicity. Antioxidants are known to protect the liver from oxidative stress. Selenium, a potent antioxidant, is a commonly used micronutrient. Here, we evaluated the protective effect of selenium on acetaminophen-induced hepatotoxicity. Treating Wistar albino mice with sodium selenite (1 mg/kg) befo...
Source: Biological Trace Element Research - September 13, 2023 Category: Biology Authors: Mylanayakanahosahalli Chandrashekar Indumathi Kamatam Swetha Kandahalli Venkataranganayaka Abhilasha Shiva Siddappa Shivamadhaiah Manjula Kumar Govinda Keerthi Prasad Chu-Huang Chen Gopal Kedihithlu Marathe Source Type: research
Oxidative stress associated with proteomic and fatty acid profiles of sperm from Nellore bulls at rest
Biol Reprod. 2023 Sep 13:ioad121. doi: 10.1093/biolre/ioad121. Online ahead of print.ABSTRACTSexual rest is a transient condition, that compromises conception rates, characterized by large volumes of ejaculate with high percentages of dead sperm observed in bulls. The biochemical mechanisms leading to this ejaculate pattern are not fully understood. Six adult resting Nellore bulls were submitted to Breeding Soundness Evaluation by four consecutive semen collections through the electroejaculation method during a 30 min period. Each ejaculate had its semen phenotypic parameters, morphology and physical aspects, evaluated. To...
Source: Reproductive Biology - September 13, 2023 Category: Reproduction Medicine Authors: Camilo Jos é Ramírez-López Edvaldo Barros Pedro Marcus Vidigal Denise Okano Silva Lidiany Lopes Gomes Rener Philipe Rodrigues Carvalho Alex Gazolla Castro Maria Cristina Baracat-Pereira Simone Eliza Facioni Guimar ães Jos é Domingos Guimarães Source Type: research
Higher cadmium and zinc accumulation in parsley (Petroselinum crispum) roots activates its antioxidants defense system
Biometals. 2023 Sep 13. doi: 10.1007/s10534-023-00529-2. Online ahead of print.ABSTRACTParsley (Petroselinum crispum) is herb with many biological and medicinal benefits for humans. However, growth on zinc (Zn) and cadmium (Cd) contaminated sites might get severely affected due to over accumulation of heavy metals (HM) in different plant tissues. Antioxidants play a crucial role in minimizing the negative effects of HM. The present study investigates the effects of Zn and Cd stress on P. crispum morphological parameters, enzymatic/non-enzymatic antioxidant profiling and metal accumulation in shoot/root. Plants were exposed...
Source: Biometals - September 13, 2023 Category: Biochemistry Authors: Ismat Nawaz Atifa Mehboob Aqib Hassan Ali Khan Tatheer Alam Naqvi Nazneen Bangash Sadia Aziz Wajiha Khan Irum Shahzadi Roc ío Barros Kifayat Ullah Mohammad Maroof Shah Source Type: research
Impact of Colored Shade Nets on Biomass Production, Essential Oil Composition and Orientin and Isoorientin Content in Lippia gracilis Schauer
The objective of this study was to evaluate the effect of ChromatiNet on vegetative growth, total antioxidant capacity, phenolic and essential oils (EOs) composition of Lippia gracilis. The plants were cultivated under full sunlight, black, blue and red ChromatiNet. The flavonoid content and antioxidant capacity were quantified spectrophotometrically. The C-glycosylflavone isomers (orientin and isoorientin) were isolated and identified by conventional spectroscopic techniques and measured using high-performance liquid chromatography-diode array detection. The EO was analysed by gas chromatography and gas chromatography-mas...
Source: Chemistry and Biodiversity - September 13, 2023 Category: Biochemistry Authors: Abra ão José Silva Viana Alexandre Alves de Carvalho Rafael Marlon Alves de Assis Simony Carvalho Mendon ça Jo ão Pedro Miranda Rocha Jos é Eduardo Brasil Pereira Pinto Suzan Kelly Vilela Bertolucci Source Type: research
In vitro establishment of cell suspension culture of Ceropegia bulbosa for improved production of cerpegin content through elicitation of engineered carbon and ZnO nanoparticles
Environ Sci Pollut Res Int. 2023 Sep 13. doi: 10.1007/s11356-023-29533-2. Online ahead of print.ABSTRACT The present investigations aimed to conserve C. bulbosa a threatened plant species and for production of cerpegin through cell culture technology using ENP elicitation. Leaf explants were aseptically cultured with normal MS medium-supplemented PGRs BA and NAA various concentrations, and the best callus induction response was recorded on 4.5 + 4.5 μM. The prospective special effects of the ENPs on plant cell cultures are the key part of our study and used to evaluate leaf callus culture proliferation with the reduction ...
Source: Environmental Science and Pollution Research International - September 13, 2023 Category: Environmental Health Authors: Komal Kashyap Suman Parihar Gyan Singh Shekhawat Source Type: research
