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Nutrition: Calcium
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Total 38423 results found since Jan 2013.
Molecular action mechanisms of two novel and selective calcium release-activated calcium channel antagonists
Int J Biol Macromol. 2023 Sep 16:126937. doi: 10.1016/j.ijbiomac.2023.126937. Online ahead of print.ABSTRACTThe prototypical calcium release-activated calcium (CRAC) channel, composed of STIM1 and Orai1, is a sought-after drug target for treating autoimmune disorders. Herein, we identified two novel and selective CRAC channel inhibitors, the indole-like compound C63368 and pyrazole core-containing compound C79413, potently and reversibly inhibiting the CRAC channel with low micromolar IC50s and sparing various off-target ion channels. These two compounds did not inhibit STIM1 activation or its coupling with Orai1, nor did ...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xiangjin Kong Feifan Wang Yan Chen Xinyao Liang Yuan Yin Hao Liu Guoqing Luo Yinping Li Songping Liang Youjun Wang Zhonghua Liu Cheng Tang Source Type: research
Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy
In conclusion, C5aR1 inhibition is proposed as a therapeutic option with the potential to exert long-term protective effect on PIPN-associated neuropathic pain and inflammation.PMID:37722320 | DOI:10.1016/j.cyto.2023.156370
Source: Cytokine - September 18, 2023 Category: Molecular Biology Authors: C Cristiano C Giorgio P Cocchiaro S Boccella M C Cesta V Castelli F M Liguori M R Cuozzo L Brandolini R Russo M Allegretti Source Type: research
Green preparation of magnetic ferroferric oxide-polyvinyl alcohol-alginate coated UiO-67 nanospheres: Characterization, adsorption properties and adsorption mechanism of methylene blue
Int J Biol Macromol. 2023 Sep 16:126967. doi: 10.1016/j.ijbiomac.2023.126967. Online ahead of print.ABSTRACTIn this paper, a kind of magnetic ferric oxide/polyvinyl alcohol/calcium alginate/UiO-67 (Fe3O4/PVA/CA/UiO-67) nanospheres with homogeneous surface interconnecting structures was prepared by using macromolecular polymer polyvinyl alcohol and sodium alginate as carriers and zirconium organic skeleton as nanocrystals. The properties of magnetic nanospheres were studied by SEM, FT-IR, TGA, XRD, BET, VSM and Zeta potential. The impression of diverse temperatures, MB concentrations, interaction time, pH, and magnetic aero...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenyu Jing Yanhui Li Qiuju Du Xinxin Pi Yuqi Wang Shiyong Zhao Yonghui Jin Source Type: research
Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signalling by lncRNA < em > Tug1 < /em > in cardiomyocytes
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00339.2023. Online ahead of print.ABSTRACTCardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca2+ levels and consists of pore-forming proteins including MCU, and various regulatory proteins such as mitochondrial calcium uptake proteins 1 and 2 (MICU1/2). The stoichiometry of these proteins influences the sensitivity to Ca2+ and activity of the complex. However, the factors that regulate their gene expression remain incompletely understood. Long non-coding RNAs (lncRNAs)...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Adam J Trewin Kate L Weeks Glenn D Wadley S éverine Lamon Source Type: research
Use of Coronary Artery Calcium Quantification and Distribution for Coronary Vascular Disease Risk Reclassification in a Primary Prevention Setting
In conclusion, the use of MESA-CACS, along with CAC distribution in primary prevention clinics, results in differential and significant reclassification of traditional scores when calculating the 10-years coronary vascular disease risk. Overall, RRS underestimates and ASCVD overestimates the cardiovascular disease risk compared with MESA-CACS.PMID:37722228 | DOI:10.1016/j.amjcard.2023.08.054
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Adel Hajj Ali Michael Nakhla Leslie Cho Raul Seballos Richard Lang Steve Feinleib Scott Flamm Paul Schoenhagen Tom Wang Milind Y Desai Source Type: research
Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina
In this study, we examined by Western blot the expression of TRPC1 in healthy control rat retinas (Sprague-Dawley, SD) and retinas with RP (P23H-1 rats). We also analyzed its specific cellular distribution by immunofluorescence to recognize changes during neurodegeneration and to determine whether its presence is consistent with high basal calcium levels and cellular survival in degenerating retinas. We found that TRPC1 immunostaining was widely distributed across the retina in both rat strains, SD and P23H, and its expression levels significantly increased in the retinas with advanced degeneration compared to the age-cont...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Elena Caminos Marina Murillo-Mart ínez Mar ía García-Belando Jos é Julio Cabanes-Sanchís Juan R Martinez-Galan Source Type: research
Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research
2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Circulation. 2023 Sep 18. doi: 10.1161/CIR.0000000000001161. Online ahead of print.ABSTRACTIn this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on structured evidence reviews, guidelines are provided for the treatment of critical poisoning from benzodiazepines, β-adrenergic receptor antagonists (also known as β-blockers), L-type calcium channel antagonists (commonly called calcium channel blockers), cocaine, cyanide, digoxin and related cardiac glycosides, local anesthetics, meth...
Source: Circulation - September 18, 2023 Category: Cardiology Authors: Eric J Lavonas Peter D Akpunonu Ann M Arens Kavita M Babu Dazhe Cao Robert S Hoffman Christopher O Hoyte Maryann E Mazer-Amirshahi Andrew Stolbach Maude St-Onge Trevonne M Thompson George Sam Wang Amber V Hoover Ian R Drennan American Heart Association Source Type: research
Facile activation of natural calcium-rich sepiolite with oxalic acid for selective Pb(II) removal: Highly-efficient performance, mechanisms and site energy distribution
Chemosphere. 2023 Sep 16:140201. doi: 10.1016/j.chemosphere.2023.140201. Online ahead of print.ABSTRACTThe design and development of adsorbents with high efficiency, selectivity, and economy for Pb(II) are essential to environmental governance and ecological safety. Herein, an oxalic acid (OA) activated natural sepiolite (nSEP) composite for highly efficient Pb(II) removal was prepared by a facile impregnation strategy. The OA activated nSEP nanocomposite (OA-nSEP) was characterized by various instrumental techniques and its adsorption performance towards Pb(II) was further evaluated through a series of static and dynamic ...
Source: Chemosphere - September 18, 2023 Category: Chemistry Authors: Shoucheng Ma Song Wei Siyuan Li Wei Wei Yao Huang Source Type: research
Enhanced adsorption of Congo red from urea/calcium chloride co-modified biochar: Performance, mechanisms and toxicity assessment
Bioresour Technol. 2023 Sep 16:129783. doi: 10.1016/j.biortech.2023.129783. Online ahead of print.ABSTRACTAdsorbents with excellent physicochemical properties and green synthetic routes are desired for efficient removal of Congo red (CR) wastewater. Hence, a novel approach was proposed within this work. Biochar NCBC obtained from Medulla Tetrapanacis was synthesized through co-modification with urea/calcium chloride. NCBC exhibited an enormous surface area (750.09 m2/g) and a micro-mesoporous composite structure. Higher nitrogen content was detected on the surface of NCBC (8.17%) compared to that of urea directly modified ...
Source: Bioresource Technology - September 18, 2023 Category: Biotechnology Authors: Zepeng Liu Yueyao Hu Jie Zhang Ying Guan Liping Zhang Ping Ye Tongtong Zhang Xingyu Huang Meng Wang Hui Gao Source Type: research
NECAB2 is an endosomal protein important for striatal function
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00615-9. doi: 10.1016/j.freeradbiomed.2023.09.003. Online ahead of print.ABSTRACTSynaptic signaling depends on ATP generated by mitochondria. Dysfunctional mitochondria shift the redox balance towards a more oxidative environment. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction. We found that neuronal calcium-binding protein 2 (NECAB2) plays a role in striatal function and mitochondrial homeostasis. NECAB2 is a predominantly endosomal striatal protein which partially colocalizes with mitochondria. This colocalization is enhance...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Diones Bueno Partha Narayan Dey Teresa Schacht Christina Wolf Verena W üllner Elena Morpurgo Liliana Rojas-Charry Lena Sessinghaus Petra Leukel Clemens Sommer Konstantin Radyushkin Luise Florin Jan Baumgart Paul Stamm Andreas Daiber Guilherme Horta Leona Source Type: research
Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function
CONCLUSION: The TRPV1 at CV23 after EA treatment might play a key role in mediating local blood perfusion but was not involved in transferring EA signals to the central nervous system (CNS). These findings collectively suggested that TRPV1 may be one of the important regulators involved in the mechanism of EA treatment for improving swallowing function in PSD.PMID:37718934 | DOI:10.1111/cns.14457
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Si Yuan Bo Qiu Ying Liang Bing Deng Jing Xu Xiaorong Tang Junshang Wu Sheng Zhou Zeli Li Hongzhu Li Qiuping Ye Lin Wang Shuai Cui Chunzhi Tang Wei Yi Lulu Yao Nenggui Xu Source Type: research
Optimizing phosphorus fertigation management zones using electromagnetic induction, soil properties, and crop yield data under semi-arid conditions
Environ Sci Pollut Res Int. 2023 Sep 19. doi: 10.1007/s11356-023-29658-4. Online ahead of print.ABSTRACTThe impact of climate change on water resource availability and soil quality is more and more emphasized under the Mediterranean basin, mostly characterized by drought and extreme weather conditions. The present study aims to investigate how electromagnetic induction technique and soil mapping combined with crop yield data can be used to optimize phosphorus (P) use efficiency by chickpea crop under drip fertigation system. The study was carried out on a 2.5-ha agricultural plot and the agronomic experiments in two growin...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Mohamed Chtouki Frederic Nguyen Sarah Garr é Abdallah Oukarroum Source Type: research
Molecular docking analysis of calcium channel blockers with ALR2 and RAGE
We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery.PMID:37720280 | PMC:PMC10504517 | DOI:10.6026/97320630019028
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Samreen Kazmi Surekha Challa Malini Devi Alaparthi Indira Devi M Swetha Sudha Nagamalla Priya Ej Source Type: research
