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Cluster of resistance-inducing genes in MCF-7 cells by estrogen, insulin, methotrexate and tamoxifen extracted via NMF
Pathol Res Pract. 2023 Jan 30;242:154347. doi: 10.1016/j.prp.2023.154347. Online ahead of print.ABSTRACTBreast cancer has become a leading cause of death for women as the economy has grown and the number of women in the labor force has increased. Several biomarkers with diagnostic, prognostic, and therapeutic implications for breast cancer have been identified in studies, leading to therapeutic advances. Resistance, on the other hand, is one of clinical practice's limitations. In this paper, we use Nonnegative Matrix Factorization to automatically extract two gene signatures from gene expression profiles of wild-type and r...
Source: Pathology, Research and Practice - February 4, 2023 Category: Pathology Authors: Angelina Boccarelli Nicoletta Del Buono Flavia Esposito Source Type: research

The Macro View – Health, Economics, and Politics and the Big Picture. What I Am Watching Here And Abroad.
September 29, 2022 Edition-----The world seems to be lurching to be overwhelmed by issues around most of the major powers being in conflict for a real risk of a global recession affecting the UK, Europe, the US and much of Asia. We seem to be in some pretty difficult times right now …In OZ Parliament is now back after the death of the Queen and it will be interesting to see how things play out and what the Budget looks like in the face of an upcoming recession.-----Major Issues.-----https://www.afr.com/politics/federal/a-nation-shorn-of-britishness-is-still-waiting-for-the-republic-20220915-p5bi90A nation shorn of Britis...
Source: Australian Health Information Technology - September 29, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Nuclear energy consumption and energy-driven growth nexus: a system GMM analysis of 27 nuclear utilizing countries across the globe
Environ Sci Pollut Res Int. 2022 Sep 12. doi: 10.1007/s11356-022-22951-8. Online ahead of print.ABSTRACTWhile the general environmental quality level continues to decline in today's global economy, aggregate energy consumption levels are often linked to countries' economic growth and environmental performances, thereby overlooking the specific roles of individual energy types. Thus, this study focuses on examining nuclear energy consumption-growth nexus in 27 selected nuclear energy-consuming countries across the globe. The system GMM estimator was applied to available post-2008 global financial crisis data spanning from 2...
Source: Environmental Science and Pollution Research International - September 11, 2022 Category: Environmental Health Authors: Mahmut Sami Duran Şeyma Bozkaya Stephen Taiwo Onifade Mustafa G öktuğ Kaya Source Type: research

Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Comprehensive analysis of carbon emissions, economic growth, and employment from the perspective of industrial restructuring: a case study of China
Environ Sci Pollut Res Int. 2021 May 10. doi: 10.1007/s11356-021-14040-z. Online ahead of print.ABSTRACTIndustrial restructuring is a significant measure for low-carbon transition. In principle, carbon emissions can be effectively reduced by limiting the output of high-emission sectors; however, the socio-economic effects of the sectors should also be considered. Moreover, owing to the limitations of the method or data, the interactions between households and production sectors have been neglected in the study of industrial restructuring, resulting in an incomplete and potentially biased understanding of the role of househ...
Source: Environmental Science and Pollution Research International - May 10, 2021 Category: Environmental Health Authors: Shukuan Bai Boya Zhang Yadong Ning Ying Wang Source Type: research

Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases. Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

American Compass Shouldn ’t Reject the Economics of Immigration
ConclusionCass and the other writers at American Compass can ignore economic theory, economic evidence, and the huge volume of peer ‐​reviewed and non‐​peer‐​reviewed research on the economics of immigration as much or as little as they choose. But they cannot get away with telling the world that it is “paper thin” and focused almost entirely on a “massive influx of Cuban refugees in Miami in 1980.” I do not hope to change Cass’s mind, but hopefully I can at least convince him and some other readers of American Compass that there is a lot more to the economics of immigration than research about Miami 40 years ago.
Source: Cato-at-liberty - December 30, 2020 Category: American Health Authors: Alex Nowrasteh Source Type: blogs

The Facts About the L-1 Visa Program
ConclusionMultinational companies play an exceptionally important role in the United States. U.S. parent companies account for nearly a  quarter of all private sector output, nearly half of all exports, and nearly three quarters of all private research and development.[44] More than 30 million American workers ’ jobs depend on multinationals. The U.S. government should not further upend investment and job growth by these companies in the United States during the economic recovery. The unemployment rate in computer occupations where many L‐​1s are employed did not increase at all during the downturn,[45] and the Unit...
Source: Cato-at-liberty - June 10, 2020 Category: American Health Authors: David J. Bier Source Type: blogs

Adaptation of the Human Gut Microbiota Metabolic Network During the First Year After Birth
This study was approved by the Ethics Committee of the Center for Public Health Research (CSISP), Valencia, Spain. All women participating in the study read and signed forms of informed consent specifically approved for this project by the Ethics Committee. Author Contributions MF, JR-H, and FP conceived this study. IA and AF carried out the computational implementation. SP-B performed the metabolomic experiments. YV generated and processed metagenomic data and collected food frequency questionnaires. All authors wrote, read, and approved the manuscript. Funding IA was supported by a Basque Government predoctoral grant...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

The Effect of Employment on Delinquent Behavior Among Youth in Hidden Situation
ConclusionResults showed that 15.1% of youths in hidden situations had jobs. They mainly worked in an Internet-based, home-based manner, with some of them being self-employed or working as freelancers, and they were able to make money from their jobs. This suggests that these youths’ being jobless is a prejudice; they are not necessarily those who lack social status as described in previous literature [e.g., Refs. (11, 12, 76)] but can engage in work during prolonged seclusion as their preferred lifestyle and use it to support their lives. Also, the relationship between employment and delinquent behavior was signifi...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

Curb Your Enthusiasm
KIP SULLIVAN Lawton Burns and Mark Pauly, economists at the Wharton School, just published an article that should be required reading for all policy makers and health services researchers. The article,  entitled “Transformation of the health care industry: Curb your enthusiasm,” appears in the latest edition of the Milbank Quarterly. Burns and Pauly undertook an enormous task and executed it well. They first sought to explain the assumptions underlying Managed Care (MC) 2.0 – the proposals promoted by the managed care movement in the wake of the HMO backlash of the late 1990s. Then they evaluated the probability t...
Source: The Health Care Blog - April 16, 2018 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Source Type: blogs

Working Cambodian Women ‘Too Poor’ to Have Children
Women in Cambodia’s garments sector work 10-12 hours a day. Credit: Michelle Tolson/IPSBy Michelle TolsonPHNOM PENH, May 31 2014 (IPS) The movement for reproductive justice sees women’s decision to have – or not have – children as a fundamental right. Should they choose to bear a child, women should have the right to care and provide for them; if they opt not to give birth, family planning services should be made available to enable women to space or prevent pregnancies. In Cambodia, where women make up 60 percent of the population of 14 million people, this fundamental right is being trampled by insecure labour co...
Source: IPS Inter Press Service - Health - May 31, 2014 Category: Global & Universal Authors: Michelle Tolson Tags: Asia-Pacific Democracy Development & Aid Economy & Trade Editors' Choice Featured Gender Gender Identity Headlines Human Rights Labour Population Poverty & MDGs Regional Categories TerraViva United Nations Women's Health Ca Source Type: news