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Specialty: Biochemistry

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Total 1283 results found since Jan 2013.

Formononetin recovered injured nerve functions by enhancing synaptic plasticity in ischemic stroke rats.
CONCLUSIONS: Formononetin recovered injured nerve functions after ischemic stroke. PI3K/AKT/ERK pathway might involve in the beneficial effect of formononetin on the neuronal differentiation and synaptic plasticity. PMID: 32081422 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - February 16, 2020 Category: Biochemistry Authors: Wu QL, Cheng YQ, Liu AJ, Zhang WD Tags: Biochem Biophys Res Commun Source Type: research

Stroke treatment: Is exosome therapy superior to stem cell therapy?
In this study, we reviewed the research progress in the application of BMSCs-derived exosomes (BMSCs-exos) and BMSCs in the treatment of stroke. In addition, the advantages and disadvantages of cell therapy and cell-free exosome therapy were described, and the possible factors that hinder the introduction of these two treatments into the clinic were analyzed. Furthermore, we reviewed the current optimization methods of cell therapy and cell-free exosome therapy. Taken together, we hypothesize that cell-free exosome therapy will have excellent research prospects in the future, and therefore, it is worth further exploring. T...
Source: Biochimie - September 29, 2020 Category: Biochemistry Authors: Cai Y, Liu W, Lian L, Xu Y, Bai X, Xu S, Zhang J Tags: Biochimie Source Type: research

Integrating serum proteomics and metabolomics to compare the common and distinct features between acute aggressive ischemic stroke (APIS) and acute non-aggressive ischemic stroke (ANPIS)
In this study, we integrated serum proteomics and metabolomics to explore the similarities and differences in pathophysiological processes between APIS and ANPIS. The global metabolic networks have been constructed, and the crucial common pathophysiological processes and the key distinct pathophysiological features between APIS and ANPIS were investigated based on the differentially expressed proteins and metabolites (DEPs/DEMs). Furthermore, pivotal serum proteins (SAA1 and S100A9) were detected in a dependent set to validate the key pathophysiological characteristics, as well as to assess the possibility of them being us...
Source: Journal of Proteomics - April 14, 2022 Category: Biochemistry Authors: Minchao Lai Xiaojun Zhang Danya Zhou Xiaojuan Zhang Mengting Zhu Qingxian Liu Ye Zhang Dian Wang Source Type: research

Therapeutic effect of fastigial nucleus stimulation is mediated by the microRNA-182 & amp; microRNA-382/BDNF signaling pathways in the treatment of post-stroke depression
In conclusion, FN stimulation increases the expression of BDNF via down-regulating the expression of miR-382/miR-182, thus exhibiting a positive effect in the management of PSD.PMID:36030655 | DOI:10.1016/j.bbrc.2022.05.038
Source: Biochemical and Biophysical Research communications - August 28, 2022 Category: Biochemistry Authors: Zhuang Zhang Dong-Jian Xia An-Ding Xu Source Type: research

MALT1 promotes necroptosis in stroke rat brain via targeting the A20/RIPK3 pathway
This study aims to explore whether MALT1 is upregulated in the brain during ischemic stroke and promotes brain cell necroptosis through enhancing the degradation of A20. Ischemic stroke model was established in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion, which showed brain injury (increase in neurological deficit score and infarct volume) concomitant with an upregulation of MALT1, a decrease in A20 level, and increases in necroptosis-associated protein levels [RIPK3, mixed lineage kinase domain-like protein (MLKL) and p-MLKL] and k63-ubiquitination of RIPK3 in...
Source: Archives of Biochemistry and Biophysics - January 5, 2023 Category: Biochemistry Authors: Zi-Mei Peng Yi-Yue Zhang Dan Wei Xiao-Jie Zhang Bin Liu Jun Peng Xiu-Ju Luo Source Type: research

Relationship between the induction of inflammatory processes and infectious diseases in patients with ischemic stroke.
Abstract Pro-inflammatory cytokines participate in the induction of ischemic stroke. So far, their participation in the cerebral ischemia was proven for the tumor necrosis factor TNF-α, interleukin-1 (IL-1), and interleukin-6 (IL-6). The release of the pro-inflammatory cytokines into the extracellular space causes the enlargement of the brain damage region, and consequently increases the neurological deficit and negatively affects the survival rate prognoses. That is confirmed by the increased concentration of pro-inflammatory cytokines in blood and the cerebrospinal fluid of patients with brain stroke, as well a...
Source: Acta Biochim Pol - September 18, 2013 Category: Biochemistry Authors: Cieślak M, Wojtczak A, Cieślak M Tags: Acta Biochim Pol Source Type: research

Comparison of intracerebral transplantation effects of different stem cells on rodent stroke models
In the present study, induced pluripotent stem cells (iPSCs), induced neural stem cells (iNSCs), mesenchymal stem cells (MSCs) and an immortalized cell line (RMNE6), representing different characteristics of stem cells, were transplanted into normal and/or injured brain areas of rodent stroke models, and their effects were compared to select suitable stem cells for cell replacement stroke therapy. The rat and mice ischaemic models were constructed using the middle cerebral artery occlusion technique. Both electrocoagulation of the artery and the intraluminal filament technique were used. The behaviour changes and fates of ...
Source: Cell Biochemistry and Function - April 1, 2015 Category: Biochemistry Authors: Yun Wu, Jianyu Wu, Rongkai Ju, Zhiguo Chen, Qunyuan Xu Tags: Research Article Source Type: research

Involvement of microRNA214 and transcriptional regulation in reductions in mevalonate pyrophosphate decarboxylase mRNA levels in stroke-prone spontaneously hypertensive rat livers.
Abstract Hypocholesterolemia has been epidemiologically identified as one of the causes of stroke (cerebral hemorrhage). We previously reported that lower protein levels of mevalonate pyrophosphate decarboxylase (MPD), which is responsible for reducing serum cholesterol levels in stroke-prone spontaneously hypertensive rats (SHRSP), in the liver were caused by a reduction in mRNA levels. However, the mechanism responsible for reducing MPD expression levels in the SHRSP liver remains unclear. Thus, we compared microRNA (miR)-214 combined with the 3'-untranslated region of MPD mRNA and heterogeneous nuclear RNA (hnR...
Source: Bioscience, Biotechnology, and Biochemistry - July 9, 2015 Category: Biochemistry Authors: Michihara A, Ide N, Mizutani Y, Okamoto M, Uchida M, Matsuoka H, Akasaki K Tags: Biosci Biotechnol Biochem Source Type: research

Protective features of peripheral monocytes/macrophages in stroke.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26584587 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 12, 2015 Category: Biochemistry Authors: Gliem M, Schwaninger M, Jander S Tags: Biochim Biophys Acta Source Type: research

Imaging of Neuroinflammation in Alzheimer's Disease, Multiple Sclerosis and Stroke: Recent Developments in Positron Emission Tomography.
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. PMID: 26643549 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 28, 2015 Category: Biochemistry Authors: Janssen B, Vugts DJ, Funke U, Molenaar GT, Kruijer PS, van Berckel BN, Lammertsma AA, Windhorst AD Tags: Biochim Biophys Acta Source Type: research

Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: a comparative study with 17 β-estradiol
Publication date: Available online 4 May 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Teresa Jover-Mengual, María Castelló-Ruiz, María C. Burguete, María Jorques, Mikahela A. López-Morales, Alicia Aliena-Valero, Andrés Jurado-Rodríguez, Salvador Pérez, José M. Centeno, Francisco J. Miranda, Enrique Alborch, Germán Torregrosa, Juan B. Salom As the knowledge on the estrogenic system in the brain grows, the possibilities to modulate it in order to afford further neuroprotection in brain damaging disorders so do it. We have previously demonstrated the ability of the selective estr...
Source: The Journal of Steroid Biochemistry and Molecular Biology - May 5, 2017 Category: Biochemistry Source Type: research

Correlation of Serum Nitric Oxide (NO) with Glasgow Coma Scale (GCS) in Acute Ischemic Stroke Patient: A Study in North India
AbstractNitric oxide (NO) is one of the key players in the pathogenesis of ischemic stroke. Limited reports are available about the serum level of NO and their correlation with Glasgow Coma Scale (GCS) score in acute (<24  h) ischemic stroke (AIS) patients. A hospital based, cross sectional study was done in North Indian population to find out correlation of serum NO and GCS in AIS patients. 50 patients of AIS and 25 healthy controls were chosen for the study. Serum NO level was measured by ELISA and GCS scores were assessed by a neurologist. Pearson correlation coefficients were analyzed to look for the relationship b...
Source: Indian Journal of Clinical Biochemistry - July 5, 2017 Category: Biochemistry Source Type: research