Stroke treatment: Is exosome therapy superior to stem cell therapy?

In this study, we reviewed the research progress in the application of BMSCs-derived exosomes (BMSCs-exos) and BMSCs in the treatment of stroke. In addition, the advantages and disadvantages of cell therapy and cell-free exosome therapy were described, and the possible factors that hinder the introduction of these two treatments into the clinic were analyzed. Furthermore, we reviewed the current optimization methods of cell therapy and cell-free exosome therapy. Taken together, we hypothesize that cell-free exosome therapy will have excellent research prospects in the future, and therefore, it is worth further exploring. There are still some issues that need to be further addressed. For example, differences between the in vivo microenvironment and in vitro culture conditions will affect the paracrine effect of stem cells. Most importantly, we believe that more preclinical and clinical design studies are required to compare the efficacy of stem cells and exosomes.
PMID: 33010339 [PubMed - as supplied by publisher]

Source: Biochimie - September 29, 2020 Category: Biochemistry Authors: Cai Y, Liu W, Lian L, Xu Y, Bai X, Xu S, Zhang J Tags: Biochimie Source Type: research