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Specialty: Neurology
Procedure: Transplants

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Total 269 results found since Jan 2013.

GATA3 improves the protective effects of bone marrow-derived mesenchymal stem cells against ischemic stroke induced injury by regulating autophagy through CREG
CONCLUSION: Our results indicated that GATA3 overexpression improved the therapeutic effects of rBMSCs transplantation against ischemic stroke induced injury by regulating autophagy through CREG.PMID:34500038 | DOI:10.1016/j.brainresbull.2021.09.001
Source: Brain Research - September 9, 2021 Category: Neurology Authors: Yongchang Li Wei Zhong Qianyi Huang Bing Lang Xiangqi Tang Source Type: research

Clinical neurorestorative cell therapies for stroke
Prog Brain Res. 2021;265:231-247. doi: 10.1016/bs.pbr.2021.06.006. Epub 2021 Aug 13.ABSTRACTClinical neurorestorative cell therapies for stroke have been explored for over 20 years. Majority cell therapies have shown neurorestorative effects for stroke on non-double-blind studies. In this review, we summarize types of cell transplantation, transplanted routes, therapeutic time windows, dosage, results of exploring trials or clinical studies, results of multicenter, double-blind or observing-blind, randomized, placebo-controlled clinical trials. The clinical application prospects of majority cell therapies for stroke need t...
Source: Brain Research - September 25, 2021 Category: Neurology Authors: Hongyun Huang Gengsheng Mao Lin Chen Hari Shanker Sharma Source Type: research

Late-onset cerebral embolism after transcatheter aortic valve implantation under direct oral anticoagulant therapy
We describe the case of a 92-year-old woman with delayed valve thrombosis causing stroke after TAVI, who developed recurrent strokes eight months after TAVI for severe aortic valve stenosis. Transesophageal echocardiography and cardiac computed tomography revealed a string-like thrombus attached to the implanted valve.
Source: Journal of Stroke and Cerebrovascular Diseases - April 28, 2022 Category: Neurology Authors: Shuhei Egashira, Takeshi Yoshimoto, Junpei Koge, Masafumi Ihara Tags: Case Report Source Type: research

Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges
AbstractIt is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells (MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander effects rather than to cell replacement in infarcted areas. This therapeutic plasticity is due to MSCs ’ ability to secrete a broad range of bioactive molecules including growth factors, trophic factors, cytokines, chemokines, and extracellular vesicles, overall known as the secretome. The secretome derivatives, such as conditioned medium (CM) or purified extracellular vesicles (EVs), exert remarka ble advantages over MSC transplantat...
Source: Molecular Neurobiology - August 3, 2022 Category: Neurology Source Type: research

Mesenchymal stem cell therapy for ischemic stroke: Novel insight into the crosstalk with immune cells
This study will discuss recent evidence that MSCs can harness the immune system by interacting with immune cells to boost neurologic recovery effectively. Moreover, a notion will be given to MSCs participating in multiple pathological processes, such as increasing cell survival angiogenesis and suppressing cell apoptosis and autophagy in several phases of ischemic stroke, consequently promoting neurological function recovery. We will conclude the review by highlighting the clinical opportunities for MSCs by reviewing the safety, feasibility, and efficacy of MSCs therapy.
Source: Frontiers in Neurology - November 8, 2022 Category: Neurology Source Type: research

The role of mesenchymal stem cell transplantation for ischemic stroke and recent research developments
Ischemic stroke is a common cerebrovascular disease that seriously affects human health. However, most patients do not practice self-care and cannot rely on the current clinical treatment for guaranteed functional recovery. Stem cell transplantation is an emerging treatment studied in various central nervous system diseases. More importantly, animal studies show that transplantation of mesenchymal stem cells (MSCs) can alleviate neurological deficits and bring hope to patients suffering from ischemic stroke. This paper reviews the biological characteristics of MSCs and discusses the mechanism and progression of MSC transpl...
Source: Frontiers in Neurology - November 16, 2022 Category: Neurology Source Type: research

Bone marrow mononuclear cells exert long-term neuroprotection in a rat model of ischemic stroke by promoting arteriogenesis and angiogenesis.
Abstract Transplanted bone marrow-derived mononuclear cells (BMMNCs) can promote arteriogenesis and angiogenesis by incorporating into vascular walls and differentiating into smooth muscle cells (SMCs) and endothelial cells (ECs). Here, we explored whether BMMNCs can enhance arteriogenesis and angiogenesis and promote long-term functional recovery in a rat model of permanent middle cerebral artery occlusion (pMCAO). Sprague-Dawley rats were injected with vehicle or 1×10(7) BMMNCs labeled with BrdU via femoral vein 24h after induction of pMCAO. Functional deficits were assessed weekly through day 42 after pMCAO, a...
Source: Brain, Behavior, and Immunity - July 24, 2013 Category: Neurology Authors: Wang J, Yu L, Jiang C, Chen M, Ou C, Wang J Tags: Brain Behav Immun Source Type: research

123I-Iomazenil Single Photon Emission Computed Tomography Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy in Rat Infarct Brain Basic Sciences
Conclusions— The present findings strongly suggest that the BMSCs may enhance functional recovery by improving the neuronal integrity in the peri-infarct area, when directly transplanted into the infarct brain at clinically relevant timing. 123I-IMZ single photon emission computed tomography may be a promising modality to scientifically prove the beneficial effects of BMSC transplantation on the host brain in clinical situation.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Saito, H., Magota, K., Zhao, S., Kubo, N., Kuge, Y., Shichinohe, H., Houkin, K., Tamaki, N., Kuroda, S. Tags: Animal models of human disease, Acute Cerebral Infarction, PET and SPECT, Other Stroke Treatment - Medical, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke.
This study was undertaken to explore the potential mechanisms underlying the neuroprotective effects of BMRMNCs in middle cerebral artery occlusion (MCAO) rat model. Rats were intravenously pre-treated with 5-FU and BMRMNCs were collected at different time points. The contents of growth factors in the supernatant and CXCR4 expression were detected by ELISA and flow cytometry, respectively. MCAO was introduced to rats, and BMMNCs and BMRMNCs collected at 7 days after 5-FU pre-treatment were independently transplanted via the tail vein 24h later. The neurological function was evaluated before cell transplantation and at 24h,...
Source: Behavioural Brain Research - July 25, 2015 Category: Neurology Authors: Li Y, Mao WW, Zhang CG, Wan L, Jing CH, Hua XM, Li ST, Cheng J Tags: Behav Brain Res Source Type: research

Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli
<span class="paragraphSection"><div class="boxTitle">Abstract</div>Transplanted neurons derived from stem cells have been proposed to improve function in animal models of human disease by various mechanisms such as neuronal replacement. However, whether the grafted neurons receive functional synaptic inputs from the recipient’s brain and integrate into host neural circuitry is unknown. Here we studied the synaptic inputs from the host brain to grafted cortical neurons derived from human induced pluripotent stem cells after transplantation into stroke-injured rat cerebral cortex. Using the rabies virus-b...
Source: Brain - January 21, 2017 Category: Neurology Source Type: research

Evaluating the effect of transplanting umbilical cord matrix stem cells on ischemic tolerance in an animal model of stroke.
CONCLUSION: The pretreatment of the transplanted umbilical cord stem cells in the striatum of ischemic rats possibly leads to restorative events, exerting a decreasing effect on cell death. Subsequently, these events may improve the motor ability and reduce ischemic injuries. PMID: 33167823 [PubMed - as supplied by publisher]
Source: Neurological Research - November 12, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Injectable biomaterial shuttles for cell therapy in stroke
Brain Res Bull. 2021 Aug 12:S0361-9230(21)00242-2. doi: 10.1016/j.brainresbull.2021.08.002. Online ahead of print.ABSTRACTIschemic stroke (IS) is the leading cause of disability and contributes to a significant socio-economic cost in the western world. Brain repair strategies investigated in the pre-clinical models include the delivery of drug or cell-based therapeutics; which is hindered by the complex anatomy and functional organization of the brain. Biomaterials can be instrumental in alleviating some of these challenges by providing a structural support, localization, immunomodulation and/or modulating cellular cross-t...
Source: Brain Research Bulletin - August 15, 2021 Category: Neurology Authors: Juhi Samal Tatiana Segura Source Type: research