Filtered By:
Procedure: Gastroschisis Repair

This page shows you your search results in order of relevance. This is page number 17.

Order by Relevance | Date

Total 4990 results found since Jan 2013.

Inhibition of CD147 Improves Oligodendrogenesis and Promotes White Matter Integrity and Functional Recovery in Mice after Ischemic Stroke
In conclusion, inhibition of CD147 promotes long-term functional recovery after stroke, at least in part, by enhancing oligodendrogenesis and white matter repair.
Source: Brain, Behavior, and Immunity - July 26, 2019 Category: Neurology Source Type: research

Translating concepts of neural repair after stroke: Structural and functional targets for recovery.
Authors: Regenhardt RW, Takase H, Lo EH, Lin DJ Abstract Stroke is among the commonest causes of adult disability worldwide, and its disease burden is shifting towards that of a long-term condition. Therefore, the development of approaches to enhance recovery and augment neural repair after stroke will be critical. Recovery after stroke involves complex interrelated systems of neural repair. There are changes in both structure (at the molecular, cellular, and tissue levels) and function (in terms of excitability, cortical maps, and networks) that occur spontaneously within the brain. Several approaches to augment n...
Source: Restorative Neurology and Neuroscience - January 15, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Pathophysiology of Blood –Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central nervous system homeostasis. Its unique characteristics allow protecting the brain from unwanted compounds, but its impairment is involved in a vast number of pathological conditions. Disruption of the BBB and increase in its permeability are key in the development of several neurological diseases and have been extensively studied in stroke. Ischemic stroke is the most prevalent type of stroke and is characterized by a myriad of pathological events triggered by an arterial occlusion that can eventually lead to fatal outcomes such ...
Source: Frontiers in Neurology - December 9, 2020 Category: Neurology Source Type: research

Towards clinical translation of 'second-generation' regenerative stroke therapies: hydrogels as game changers?
Trends Biotechnol. 2021 Nov 20:S0167-7799(21)00255-9. doi: 10.1016/j.tibtech.2021.10.009. Online ahead of print.ABSTRACTStroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to 'first-generation' stem cell-based therapies. Hydrogels can remodel the hostile stroke microenvironment to aid endogenous and exogenous regenerative repair processes. However, no clinical trials have yet been successfully commissioned for these 'second-generation' hydrogel-based therapies for chronic ischaemic stroke regeneration. This review recommends a path forward to im...
Source: Trends in Biotechnology - November 24, 2021 Category: Biotechnology Authors: John D Totten Hani A Alhadrami Essam H Jiffri Calum J McMullen F Philipp Seib Hilary V O Carswell Source Type: research

Postoperative Stroke After Type A Aortic Dissection Repair: Hemorrhage Versus Ischemia
ConclusionsPostoperative hemorrhagic stroke was associated with poorer neurological outcomes and lower survival rates than those with ischemic stroke. Patients who have complex arch replacement, long cardiopulmonary bypass and aortic clamping times are at risk for postoperative hemorrhagic stroke and should have intensive neurological surveillance for early diagnosis and treatment after ATAAD repair surgery.
Source: World Journal of Surgery - February 1, 2022 Category: Surgery Source Type: research

Neutrophil Extracellular Trap Targeting Protects Against Ischemic Damage After Fibrin-Rich Thrombotic Stroke Despite Non-Reperfusion
Stroke is one of the most prevalent diseases worldwide caused primarily by a thrombotic vascular occlusion that leads to cell death. To date, t-PA (tissue-type plasminogen activator) is the only thrombolytic therapy approved which targets fibrin as the main component of ischemic stroke thrombi. However, due to its highly restrictive criteria, t-PA is only administrated to less than 10% of all stroke patients. Furthermore, the research in neuroprotective agents has been extensive with no translational results from medical research to clinical practice up to now. Since we first described the key role of NETs (Neutrophil Ext...
Source: Frontiers in Immunology - February 16, 2022 Category: Allergy & Immunology Source Type: research

Ischemic stroke and intestinal flora: an insight into brain –gut axis
AbstractStroke is a type of cerebrovascular disease that significantly endangers human health and lowers quality of life. This understandably places a heavy burden on society and families. In recent years, intestinal flora has attracted increasing attention from scholars worldwide, and its association with ischemic stroke is becoming a hot topic of research amongst researchers in field of stroke. After suffering from a stroke, intestinal microbial dysbiosis leads to increased intestinal permeability and activation of the intestinal immune system, which in turn leads to ectopic intestinal bacteria and pro-inflammatory cells...
Source: European Journal of Medical Research - May 25, 2022 Category: Research Source Type: research

Harnessing cortical plasticity via gabapentinoid administration promotes recovery after stroke
AbstractStroke causes devastating sensory-motor deficits and long-term disability due to disruption of descending motor pathways. Restoration of these functions enables independent living and therefore represents a high priority for those afflicted by stroke. Here, we report that daily administration of gabapentin, a clinically approved drug already used to treat various neurological disorders, promotes structural and functional plasticity of the corticospinal pathway after photothrombotic cortical stroke in adult mice. We found that gabapentin administration had no effects on vascular occlusion, haemodynamic changes nor s...
Source: Brain - May 23, 2022 Category: Neurology Source Type: research

Regulatory T lymphocytes as a therapy for ischemic stroke
AbstractUnrestrained excessive inflammatory responses exacerbate ischemic brain injury and impede post-stroke brain recovery. CD4+CD25+Foxp3+ regulatory T (Treg) cells play important immunosuppressive roles to curtail inflammatory responses and regain immune homeostasis after stroke. Accumulating evidence confirms that Treg cells are neuroprotective at the acute stage after stroke and promote brain repair at the chronic phases. The beneficial effects of Treg cells are mediated by diverse mechanisms involving cell –cell interactions and soluble factor release. Multiple types of cells, including both immune cells and non-i...
Source: Seminars in Immunopathology - December 5, 2022 Category: Pathology Source Type: research

Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8
AbstractAcidic postconditioning by transient CO2 inhalation applied within minutes after reperfusion has neuroprotective effects in the acute phase of stroke. However, the effects of delayed chronic acidic postconditioning (DCAPC) initiated during the subacute phase of stroke or other acute brain injuries are unknown. Mice received daily DCAPC by inhaling 5%/10%/20% CO2 for various durations (three cycles of 10- or 20-min CO2 inhalation/10-min break) at days 3 –7, 7–21, or 3–21 after photothrombotic stroke. Grid-walk, cylinder, and gait tests were used to assess motor function. DCAPC with all CO2 concentrations signi...
Source: Translational Stroke Research - February 28, 2023 Category: Neurology Source Type: research

Role of IL-17A in different stages of ischemic stroke
Int Immunopharmacol. 2023 Apr;117:109926. doi: 10.1016/j.intimp.2023.109926. Epub 2023 Mar 11.ABSTRACTInterleukin-17A (IL-17A) plays an important role in the progression of ischemic stroke. IL-17A mediates the endothelial inflammatory response, promotes water and sodium retention, and changes the electrophysiological structure of the atrium, accelerating the progression of ischemic stroke risk factors such as atherosclerotic plaques, hypertension, and atrial fibrillation. In the acute phase of ischemic stroke, IL-17A mediates neuronal injury through neutrophil chemotaxis to the site of injury, the induction of neuronal apo...
Source: International Immunopharmacology - April 4, 2023 Category: Allergy & Immunology Authors: Xiuping Chen Yi Zhang Qian Ding Yanru He Hui Li Source Type: research