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Nutrition: Sodium Chloride
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Folium < em > Ginkgo < /em > extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation
CONCLUSIONS: Xingxiong injection prevents cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome. These findings provide experimental evidence for clinical use of drugs in the treatment of ischaemic stroke.PMID:35060427 | DOI:10.1080/13880209.2021.2014895
Source: Pharmaceutical Biology - January 21, 2022 Category: Drugs & Pharmacology Authors: Ting Zhu Bin-Yu Fang Xiang-Bao Meng Shu-Xia Zhang Hong Wang Ge Gao Fei Liu Yu Wu Jin Hu Gui-Bo Sun Xiao-Bo Sun Source Type: research
Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research
Chronic Kidney Disease Is Poised To Become The Black Lung of Climate Change
It’s official. July was the world’s hottest month on record, scientists from the European climate monitoring agency confirmed on Aug. 8, a full 1.5°C (2.7°F) warmer than pre-industrial averages, offering a potent taste of what is to come in a world made hotter by climate change. The wildfires and heat waves that wreathed much of the northern hemisphere in smoke this summer? Expect more of the same. The surge in deaths and hospitalization from heat stress and stroke? Ditto. An increase in chronic kidney disease of non-traditional origin? Yup. Wait, what?
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Source: TIME: Health - August 9, 2023 Category: Consumer Health News Authors: Aryn Baker Tags: Uncategorized climate change Climate Is Everything healthscienceclimate Source Type: news
Dietary potassium: A key mediator of the cardiovascular response to dietary sodium chloride
Abstract: Potassium and sodium share a yin/yang relationship in the regulation of blood pressure (BP). BP is directly associated with the total body sodium and negatively correlated with the total body potassium. Epidemiologic, experimental, and clinical studies have shown that potassium is a significant regulator of BP and further improves cardiovascular outcomes. Hypertensive cardiovascular damage, stroke, and stroke-related death are accelerated by salt intake but might be curbed by increasing dietary potassium intake. The antihypertensive effect of potassium supplementation appears to occur through several mechanisms t...
Source: Journal of the American Society of Hypertension - June 3, 2013 Category: Cardiology Authors: Mehmet Kanbay, Yeter Bayram, Yalcin Solak, Paul W. Sanders Tags: Review Articles Source Type: research
Some types of vegetarian diet can raise heart disease risk
Conclusion
This large pooled cohort study seems to demonstrate an association between a healthy plant-based diet and reduced risk of coronary heart disease, and an increased risk of heart disease with an unhealthy plant-based diet.
This adds to the evidence base supporting the possible benefits of healthy plant-based diets in protecting against certain illnesses. However there are some limitations to the research:
The cohort included only health professionals from the US so might not be representative of wider populations in the UK or elsewhere.
The study can't provide information on the benefits or otherwise of this d...
Source: NHS News Feed - July 18, 2017 Category: Consumer Health News Tags: Food/diet Source Type: news
KL 10 Animal models for gestational hypertension
Publication date: July 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 9 Author(s): Christian Delles, Delyth Graham, Hannah L. Morgan, Heather Y. Small, Shona Ritchie The prevalence of cardiovascular diseases and particularly of hypertension is increasing worldwide. Consequently, the number of women with hypertension in pregnancy is also increasing. Several rodent models of hypertension have been characterised in depth but only few models exhibit the complex cardiovascular phenotype that is typically seen in human hypertension. The stroke-prone spontaneously hypertensi...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 13, 2017 Category: OBGYN Source Type: research
This diet advice could kill you
The American Heart Association says sodium in salt raises blood pressure. They say it increases the risk for heart disease and stroke.
But the latest science says otherwise…
A British review of 34 clinical trials showed that cutting down on salt reduced blood pressure only slightly for people with hypertension.1
And a new study in The Lancet found that some low-salt diets could put you at GREATER risk of heart disease and death.2
Researchers analyzed data from 133,118 people. They wanted to see if there was a link between high sodium and heart attack, stroke and death
The results were startling. People on “he...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Randall Hall Tags: Health Heart Health Men's Health Nutrition Women's Health Source Type: news
CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period.
Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.
Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF
Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.
CONCLUSION: Our findings suggest that chronic H2 gas inhalation may help prevent LV hypertrophy in hypertensive DS rats.
PMID: 29902079 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Hypertension - June 14, 2018 Category: Cardiology Authors: Matsuoka H, Miyata S, Okumura N, Watanabe T, Hashimoto K, Nagahara M, Kato K, Sobue S, Takeda K, Ichihara M, Iwamoto T, Noda A Tags: Clin Exp Hypertens Source Type: research
Molecules, Vol. 24, Pages 1722: Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats
The objective of the present work was to study the neuroprotective activity of a new specific JNK inhibitor, IQ-1S (11H-indeno[1,2-b]quinoxalin-11-one oxime sodium salt), in the model of global cerebral ischemia (GCI) in rats compared with citicoline (cytidine-5&prime;-diphosphocholine), a drug approved for the treatment of acute ischemic stroke and to search for pleiotropic mechanisms of neuroprotective effects of IQ-1S. The experiments were performed in a rat model of ischemic stroke with three-vessel occlusion (model of 3VO) affecting the brachiocephalic artery, the left subclavian artery, and the left common ca...
Source: Molecules - May 2, 2019 Category: Chemistry Authors: Mark B. Plotnikov Galina A. Chernysheva Oleg I. Aliev Vera I. Smol ’iakova Tatiana I. Fomina Anton N. Osipenko Victoria S. Rydchenko Yana J. Anfinogenova Andrei I. Khlebnikov Igor A. Schepetkin Dmitriy N. Atochin Tags: Article Source Type: research
Experimental study on healthy volunteers based on magnetic induction brain edema monitoring system.
CONCLUSIONS: We preliminarily verify that the system can be used for cerebral edema monitoring.
PMID: 31045546 [PubMed - as supplied by publisher]
Source: Technology and Health Care - April 27, 2019 Category: Medical Devices Authors: Xu J, Li G, Zhao S, Chen M, Chen J, Xu L, Wang F, Bai Z, Qin M, Sun J Tags: Technol Health Care Source Type: research
Hypertension and brachydactyly syndrome associated with vertebral artery malformation caused by a PDE3A missense mutation.
CONCLUSIONS: Genetic screening can significantly improve the diagnosis of HTNB patients at an early age. Our study not only adds to the spectrum of PDE3A mutations in the Chinese population and extends the phenotype of HTNB patients to include vertebral malformation but also improves the awareness of pathogenesis in HTNB patients. We emphasize the importance of antihypertensive treatment and long term follow-up to prevent stroke and adverse cardiovascular events.
PMID: 31549136 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - September 23, 2019 Category: Cardiology Authors: Fan P, Zhang D, Yang KQ, Zhang QY, Luo F, Lou Y, Liu YX, Zhang HM, Song L, Cai J, Wu HY, Zhou XL Tags: Am J Hypertens Source Type: research
IJERPH, Vol. 16, Pages 4151: Being Conscious of Water Intake Positively Associated with Sufficient Non-Alcohol Drink Intake Regardless of Seasons and Reasons in Healthy Japanese; the KOBE Study: A Cross Sectional Study
to
Tomonori Okamura
The present study sought to clarify if being conscious of water intake (CWI) is associated with sufficient non-alcohol drink (NAD) intake. We used data of healthy participants without diabetes, aged 40&ndash;74 years, in the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) study. The association between being CWI and NAD intake was evaluated by multivariate linear regression analyses after adjusting for age, sex, surveyed months (seasons), alcohol drinking, health-awareness life habits, socioeconomic factors, serum osmolarity, estimated daily salt intake, and reasons for NAD intake. Amo...
Source: International Journal of Environmental Research and Public Health - October 27, 2019 Category: Environmental Health Authors: Tomofumi Nishikawa Naomi Miyamatsu Aya Higashiyama Yoshimi Kubota Yoko Nishida Takumi Hirata Daisuke Sugiyama Kazuyo Kuwabara Sachimi Kubo Yoshihiro Miyamoto Tomonori Okamura Tags: Article Source Type: research
