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Therapy: Statin Therapy

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Total 73 results found since Jan 2013.

Changes in the prevalence of statin use in Germany - findings from national health interview and examination surveys 1997-1999 and 2008-2011.
CONCLUSION: The increase in the prevalence of statin use in Germany between the two national health surveys (1997-1999 and 2008-2011) reflects the implementation of current guideline recommendations without evidence for inequalities according to gender, education, type of health insurance or region of residence. These population-based data add to information on statin prescription obtained from statutory health insurance data. Limitations of survey-based information derive from potential misclassification and selection bias as well as large time gaps between the survey periods. Further studies are needed to examine why the...
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - May 19, 2017 Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research

CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation
This study aimed to evaluate the efficacy of statin treatment for atrial fibrillation prevention in elderly patients with hypertension, and to determine if comorbidity or CHADS2 (Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, prior Stroke or transient ischemic attack) score can predict the effectiveness of statin treatment. Methods: Patients aged ≥65 years with hypertension were identified from a National Health Insurance research database (a systemic sampling from 2000 to 2009 with a total of 1,000,000 subjects). Medical records of 27,002 patients were used in this study, in which 2400 (8....
Source: The American Journal of Medicine - January 17, 2013 Category: Journals (General) Authors: Chen-Ying Hung, Ching-Heng Lin, El-Wui Loh, Chih-Tai Ting, Tsu-Juey Wu Tags: Clinical research studies Source Type: research

Could statins also protect against dementia?
Conclusion This study using a large, older age, Asian population finds an association between statin use and reduced risk of developing dementia over an average five years of follow-up. The main limitation of this study is that it can demonstrate an association, but it cannot definitely prove cause and effect. The study has adjusted for a number of measured confounders, but this may not fully account for these or other factors (such as lifestyle habits) that may be involved in the relationship.  Also, while the research has used what can be expected to be a fairly reliable research database, there is also the possibility...
Source: NHS News Feed - April 14, 2014 Category: Consumer Health News Tags: Medication Neurology Source Type: news

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

The Jekyll and Hyde of Statins
By Drs. David Niesel and Norbert Herzog, Medical Discovery News Cholesterol-lowering drugs called statins are the most prescribed drug ever. About 30 percent of Americans are currently taking statins such as Crestor, Lipitor, Mevacor and Zocor. Overall, statins can be good thing, but as with all drugs, there are some negative effects. Statins lower cholesterol by inhibiting a protein called HMG-CoA reductase. Since high cholesterol levels are linked to heart disease, statins can reduce the risks of heart attack and stroke, two of the leading causes of death in the United States. Recent reports from the American Heart Assoc...
Source: Science - The Huffington Post - February 3, 2016 Category: Science Source Type: news

Predictors of Cardiovascular Hospitalization in Giant Cell Arteritis: Effect of Statin Exposure. A French Population-based Study.
CONCLUSION: Patients with GCA present a high risk of cardiovascular hospitalization after diagnosis. In patients with incident GCA from the Midi-Pyrenees region, southern France, statin therapy was associated with reduced cardiovascular hospitalizations. PMID: 27585686 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - September 3, 2016 Category: Rheumatology Tags: J Rheumatol Source Type: research

Comparative Effectiveness of Combination Therapy with Statins and Angiotensin ‐Converting Enzyme Inhibitors versus Angiotensin II Receptor Blockers in Patients with Coronary Heart Disease: A Nationwide Population‐Based Cohort Study in Korea
ConclusionA MACCE was less likely to occur in patients who received a statin ‐ARB than in those who received a statin‐ACEI. Similar trends were seen in cardiovascular mortality and the occurrence of recurrent MI but not stroke. The availability of statin‐ARB fixed‐dose combinations may have contributed to the improved outcomes in the statin‐ARB cohort by reducing p ill burden and improving medication adherence. Further research is warranted to validate our findings and to address whether a particular statin‐ARB combination is more effective than other combinations.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - November 6, 2018 Category: Drugs & Pharmacology Authors: Jimin Lee, Sukhyang Lee Tags: Original Research Article Source Type: research

Effects of Statin Therapy on the Risk of Intracerebral Hemorrhage in Korean Patients with Hyperlipidemia
ConclusionStatin therapy was associated with a decreased ICH risk and improvements in ischemic cardiovascular and cerebrovascular outcomes in Korean patients with hyperlipidemia. Further large ‐scale clinical studies are needed to clarify the impact of statins on the risk of developing ICH.This article is protected by copyright. All rights reserved.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 26, 2018 Category: Drugs & Pharmacology Authors: Minji Jung, Sukhyang Lee Tags: Original Research Article Source Type: research

The impact of statin therapy after surgical or endovascular treatment of cerebral aneurysms.
CONCLUSIONSConsistent statin therapy was significantly associated with better prognosis after coil embolization or surgical clipping of cerebral aneurysms. PMID: 31125972 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 23, 2019 Category: Neurosurgery Authors: Song TJ, Oh SH, Kim J Tags: J Neurosurg Source Type: research

Efficacy and Safety of High-intensity Statins in Patients with Acute Myocardial Infarction: An Asian Perspective
ConclusionsAMI patients in Taiwan with HIS had similar clinical outcomes to those with non-HIS. Using HIS for effective reduction of low-density lipoprotein cholesterol is safe in Taiwan.
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research

Mediation effect of herpes zoster derived by statin use on cardiovascular disease risk.
Conclusions: This study showed that statin use reduced CVD by 10%, but the protective effect of statin use against CVD was mitigated by approximately 10% through the development of HZ caused by statin use. PMID: 32550721 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - June 18, 2020 Category: Internal Medicine Authors: Kim SH, Yun SC, Khang YH, Kim MC, Kwon SU, Park GM, Cho YR, Lee KM, Kim MH Tags: Korean J Intern Med Source Type: research

Major adverse cardiovascular and limb events in patients with diabetes treated with GLP-1 receptor agonists vs DPP-4 inhibitors
Conclusions/interpretationIn individuals with diabetes, the use of GLP1RAs was associated with significantly lower risks of major adverse limb events when compared with the use of DPP4is. The reduction in risk was driven largely by reduced rate of amputations. Moreover, treatment with GLP1RAs was also associated with lower risks of cardiovascular death, non-fatal stroke, non-fatal myocardial infarction and death from any cause. However, some unexplored confounding factors may exist in this observation study and future large-scale randomised controlled trials are needed.Graphical abstract
Source: Diabetologia - August 24, 2021 Category: Endocrinology Source Type: research