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Infectious Disease: Adenoviruses

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Total 114 results found since Jan 2013.

Administration of intramuscular AAV-BDNF and intranasal AAV-TrkB promotes neurological recovery via enhancing corticospinal synaptic connections in stroke rats
In this study, we performed non-invasive treatment methods focused on intramuscular injection into stroke-injured forelimb muscles, or intranasal administration using adeno-associated virus (AAV) vectors carrying genes encoding BDNF or TrkB. In a permanent rat middle cerebral artery occlusion (MCAO) model, we assessed the effects of combination therapy with AAV-BDNF and AAV-TrkB on motor functional recovery and synaptic plasticity of the corticospinal connections. Our results showed that BDNF or TrkB gene transduced in the spinal anterior horn neurons and cerebral cortical neurons. Compared to AAV vector treatment alone, b...
Source: Experimental Neurology - October 2, 2022 Category: Neurology Authors: Jing Wang Yichen Cai Jingyi Sun Hua Feng Xiaoyu Zhu Qian Chen Feng Gao Qingbin Ni Leilei Mao Mingfeng Yang Baoliang Sun Source Type: research

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery
Angiogenic response is essential for ischemic brain repair. The von Willebrand factor (VWF)–cleaving protease disintegrin and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) is required for endothelial tube formation in vitro, but there is currently no in vivo evidence supporting a function of ADAMTS13 in angiogenesis. Here we show that mice deficient in ADAMTS13 exhibited reduced neovascularization, brain capillary perfusion, pericyte and smooth muscle cell coverage on microvessels, expression of the tight junction and basement membrane proteins, and accelerated blood-brain barrier (BBB) break...
Source: Blood - July 6, 2017 Category: Hematology Authors: Xu, H., Cao, Y., Yang, X., Cai, P., Kang, L., Zhu, X., Luo, H., Lu, L., Wei, L., Bai, X., Zhu, Y., Zhao, B.-Q., Fan, W. Tags: Plenary Papers, Thrombosis and Hemostasis, Vascular Biology Source Type: research

Elabela, a Novel Peptide, Exerts Neuroprotective Effects Against Ischemic Stroke Through the APJ/miR-124-3p/CTDSP1/AKT Pathway
In conclusion, these results indicated that ELA could alleviate neuronal apoptosis and axonal damage by upregulating miR-124-3p and activating the CTDSP1/AKT signaling pathway. This study, for the first time, verified the protective effect of ELA against neuronal injury after ischemia and revealed the underlying mechanisms. We demonstrated the potential for the use of ELA as a therapeutic agent in the treatment of ischemic stroke.PMID:37106272 | DOI:10.1007/s10571-023-01352-6
Source: Cellular and Molecular Neurobiology - April 27, 2023 Category: Cytology Authors: Kang-Long Zhang Shuang-Mei Li Jing-Yu Hou Ying-Hui Hong Xu-Xiang Chen Chang-Qing Zhou Hao Wu Guang-Hui Zheng Chao-Tao Zeng Hai-Dong Wu Jia-Ying Fu Tong Wang Source Type: research

Gene therapy of adeno-associated virus (AAV) vectors in preclinical models of ischemic stroke
CNS Neurosci Ther. 2023 Aug 8. doi: 10.1111/cns.14392. Online ahead of print.ABSTRACTStroke has been associated with devastating clinical outcomes, with current treatment strategies proving largely ineffective. Therefore, there is a need to explore alternative treatment options for addressing post-stroke functional deficits. Gene therapy utilizing adeno-associated viruses (AAVs) as a critical gene vector delivering genes to the central nervous system (CNS) gene delivery has emerged as a promising approach for treating various CNS diseases. This review aims to provide an overview of the biological characteristics of AAV vec...
Source: CNS Neuroscience and Therapeutics - August 8, 2023 Category: Neuroscience Authors: Jing Wang Mengna Zhu Jingyi Sun Lina Feng Mingfeng Yang Baoliang Sun Leilei Mao Source Type: research

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice
Publication date: 9 April 2019Source: Cell Reports, Volume 27, Issue 2Author(s): Jianxiong Zeng, Yaoming Wang, Zhifei Luo, Lin-Chun Chang, Ji Seung Yoo, Huan Yan, Younho Choi, Xiaochun Xie, Benjamin E. Deverman, Viviana Gradinaru, Stephanie L. Gupton, Berislav V. Zlokovic, Zhen Zhao, Jae U. JungSummaryExcessive and unresolved neuroinflammation is a key component of the pathological cascade in brain injuries such as ischemic stroke. Here, we report that TRIM9, a brain-specific tripartite motif (TRIM) protein, was highly expressed in the peri-infarct areas shortly after ischemic insults in mice, but expression was decreased ...
Source: Cell Reports - April 10, 2019 Category: Cytology Source Type: research

MST4 modulates the neuro-inflammatory response by regulating I κBα signaling pathway and affects the early outcome of experimental ischemic stroke in mice.
MST4 modulates the neuro-inflammatory response by regulating IκBα signaling pathway and affects the early outcome of experimental ischemic stroke in mice. Brain Res Bull. 2019 Nov 10;: Authors: Luan D, Zhang Y, Yuan L, Chu Z, Ma L, Xu Y, Zhao S Abstract MST4 limits peripheral, macrophage-dependent inflammatory responses through direct phosphorylation of the adaptor TRAF6; though its role in neuro-inflammation is unclear. We investigated microglia expression of MST4 and whether is attenuates neuro-inflammatory response after cerebral ischemia-reperfusion injury in mice. Adult male C57BL6 mice were su...
Source: Brain Research Bulletin - November 9, 2019 Category: Neurology Authors: Luan D, Zhang Y, Yuan L, Chu Z, Ma L, Xu Y, Zhao S Tags: Brain Res Bull Source Type: research

Knockdown of Arginyl-tRNA Synthetase Attenuates Ischemia-Induced Cerebral Cortex Injury in Rats After Middle Cerebral Artery Occlusion
AbstractSome researchers have previously shown that RNAi knockdown of arginyl-tRNA synthetase (ArgRS) before or after a hypoxic injury can rescue animals from death, based on the model organism,C. elegans. However, there has been no study on the application of arginyl-tRNA synthetase knockdown in treating mammalian ischemic stroke, and its potential mechanism and effect on ischemic brain damage are still unknown. Here, we focused on the Rars gene, which encodes an arginyl-tRNA synthetase, and examined the effects of Rars knockdown in a permanent middle cerebral artery occlusion model in rats. To achieve this aim, adult mal...
Source: Translational Stroke Research - March 26, 2020 Category: Neurology Source Type: research

Treatment with AAV1-Rheb(S16H) provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke
We recently reported that upregulation of the constitutively active ras homolog enriched in brain [Rheb(S16H)], which induces the activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, can protect adult neurons, mediated by the induction of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), in animal models of neurodegenerative diseases. Here we show that neuronal transduction of Rheb(S16H) using adeno-associated virus serotype 1 provides neuroprotection in a mouse model of photothrombosis-induced ischemic stroke. Rheb(S16H)-expressing neurons exhibited neurotrophic effec...
Source: NeuroReport - August 13, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research

Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3
CONCLUSIONS: This study is the first to indicate that inhibition of BRD4 delays fibrous scarring after ischemic stroke through mechanisms involving the phosphorylation of Smad2/3.PMID:36244457 | DOI:10.1016/j.brainres.2022.148126
Source: Brain Research - October 16, 2022 Category: Neurology Authors: Xuemei Li Huimin Zhu Jun Wen Jiagui Huang Yue Chen Mingfen Tian Jiangxia Ren Li Zhou Qin Yang Source Type: research

Peroxisome Proliferator-Activated Receptor {beta}/{delta} Alleviates Early Brain Injury After Subarachnoid Hemorrhage in Rats Basic Sciences
Conclusions— PPARβ/’s overexpression may attenuate early brain injury after rats’ SAH administration, which reduces neural apoptosis possibly through blocking NF-B/MMP-9 pathway.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Teng, Z., Jiang, L., Hu, Q., He, Y., Guo, Z., Wu, Y., Huang, Z., Cao, F., Cheng, C., Sun, X., Guo, Z. Tags: Animal Models of Human Disease, Cell Signaling/Signal Transduction, Cerebrovascular Disease/Stroke Basic Sciences Source Type: research