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Total 2417 results found since Jan 2013.

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

'Safe' stem cell therapy may help stroke recovery
Conclusion This study provides evidence that a new technique using a patient's own stem cells to aid the recovery from severe ischaemic stoke is feasible and appears to be safe. It was not designed to test whether the technique was better than doing nothing or better than other types of care or treatment. The authors are perfectly clear that this "proof-of-concept study was not designed with a control group or powered to be able to detect efficacy". This means we cannot be sure that the improvements seen in the five patients were caused by the stem cell treatment. They could have occurred anyway as part of the na...
Source: NHS News Feed - August 11, 2014 Category: Consumer Health News Tags: Genetics/stem cells Heart/lungs Source Type: news

Perioperative stroke.
CONCLUSIONS: Perioperative stroke carries a significant clinical burden. The incidence of perioperative stroke may be higher than previously recognized, and there are diverse pathophysiologic mechanisms. There are many opportunities for further investigation of the pathophysiology, prevention, and management of perioperative stroke. PMID: 26391795 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - September 21, 2015 Category: Anesthesiology Authors: Vlisides P, Mashour GA Tags: Can J Anaesth Source Type: research

Perioperative stroke
Conclusions Perioperative stroke carries a significant clinical burden. The incidence of perioperative stroke may be higher than previously recognized, and there are diverse pathophysiologic mechanisms. There are many opportunities for further investigation of the pathophysiology, prevention, and management of perioperative stroke.
Source: Canadian Journal of Anesthesia - January 20, 2016 Category: Anesthesiology Source Type: research

Impact of Mechanical Thrombectomy on the Organization of the Management of Acute Ischemic Stroke
Background: Several trials and meta-analyses have recently demonstrated the superiority of endovascular therapy over standard medical treatment in patients presenting with acute ischemic stroke. In order to offer the best possible treatment to a maximum number of patients, many stroke care networks probably have to be reorganized. After analyzing the reliability of data in the literature, an algorithm is suggested for a pre-hospital and in-hospital alert system to improve the timeliness of subsequent treatment: a drip-and-ship approach. Summary: Five recent well-designed randomized studies have demonstrated the benefit of ...
Source: European Neurology - January 16, 2016 Category: Neurology Source Type: research

Increased Plasma Matrix Metalloproteinase-9 Levels Contribute to Intracerebral Hemorrhage during Thrombolysis after Concomitant Stroke and Influenza Infection
Conclusion: Preexisting influenza A virus infection led to increased plasma MMP-9 and TIMP-1 levels in mice undergoing thrombolysis after induced stroke. MMP-9 levels closely correlated with intracerebral bleeding after thrombolysis during concomitant infection and stroke. Thus, our data indicate that thrombolysis may be dangerous during influenza infection. MMP-9 inhibitors might be considered to reduce the side effects of thrombolysis during concomitant infection and stroke.Cerebrovasc Dis Extra 2016;6:50-59
Source: Cerebrovascular Diseases Extra - August 24, 2016 Category: Neurology Source Type: research

The Association Between Mild Intraoperative Hypotension and Stroke in General Surgery Patients.
CONCLUSIONS: In our propensity score-matched case-control study, we did not find an association between intraoperative hypotension, defined as MAP < 70 mm Hg, and postoperative stroke. PMID: 27636576 [PubMed - in process]
Source: Anesthesia and Analgesia - September 19, 2016 Category: Anesthesiology Authors: Hsieh JK, Dalton JE, Yang D, Farag ES, Sessler DI, Kurz AM Tags: Anesth Analg Source Type: research

Perioperative Low Arterial Oxygenation Is Associated With Increased Stroke Risk in Cardiac Surgery.
CONCLUSIONS: Odds of stroke after cardiac surgery are increased in patients with a low minimum PaO2 within 24 hours of surgery. Results should be validated in an independent cohort. Further characterizing the underlying etiology of hypoxic episodes will be important to improve patient outcomes. PMID: 28614129 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - June 12, 2017 Category: Anesthesiology Authors: Dunham AM, Grega MA, Brown CH, McKhann GM, Baumgartner WA, Gottesman RF Tags: Anesth Analg Source Type: research

Defining an Intraoperative Hypotension Threshold in Association with Stroke in Cardiac Surgery
Conclusions Hypotension is a potentially modifiable risk factor for perioperative stroke. The study ’s findings suggest that mean arterial pressure may be an important intraoperative therapeutic hemodynamic target to reduce the incidence of stroke in patients undergoing cardiopulmonary bypass.
Source: Anesthesiology - August 14, 2018 Category: Anesthesiology Source Type: research

Clinical Response to Procedural Stroke Following Carotid Endarterectomy: A  Delphi Consensus Study
CONCLUSION: In patients having a stroke following carotid endarterectomy, expedited diagnostics should be performed initially in most phases. In patients who experience an ipsilateral intra-operative stroke following carotid clamp release, immediate re-exploration of the index carotid artery is recommended.PMID:34312072 | DOI:10.1016/j.ejvs.2021.05.033
Source: PubMed: Eur J Vasc Endovasc ... - July 27, 2021 Category: Surgery Authors: Armelle J A Meershoek Djurre D de Waard Jaap Trappenburg Clark J Zeebregts Richard Bulbulia Jaap L J Kappelle Gert-Jan de Borst Delphi consensus experts panel Source Type: research

Neurological scoring and gait kinematics to assess functional outcome in an ovine model of ischaemic stroke
ConclusionThis study developed repeatable methods to assess function in sheep using composite scoring and gait kinematics, allowing for the evaluation of deficit 3 days post-stroke. Despite utility of each method independently, there was poor association observed between gait kinematics, composite scoring, and infarct volume on PCA. This suggests that each of these measures has discreet utility for the assessment of stroke deficit, and that multimodal approaches are necessary to comprehensively characterise functional impairment.
Source: Frontiers in Neurology - February 20, 2023 Category: Neurology Source Type: research

Improving the translation of animal ischemic stroke studies to humans
Abstract Despite testing more than 1,026 therapeutic strategies in models of ischemic stroke and 114 therapies in human ischemic stroke, only one agent tissue plasminogen activator has successfully been translated to clinical practice as a treatment for acute stroke. Though disappointing, this immense body of work has led to a rethinking of animal stroke models and how to better translate therapies to patients with ischemic stroke. Several recommendations have been made, including the STAIR recommendations and statements of RIGOR from the NIH/NINDS. In this commentary we discuss additional aspects that may be imp...
Source: Metabolic Brain Disease - March 6, 2015 Category: Neurology Source Type: research

Covert stroke after non-cardiac surgery: a prospective cohort study
Conclusions This international multicentre study suggests that 1 in 10 patients ≥65 yr of age experiences a perioperative covert stroke. A larger study is required to determine the impact of perioperative covert stroke on patient-important outcomes. Clinical trial registration NCT01369537.
Source: British Journal of Anaesthesia - July 19, 2016 Category: Anesthesiology Authors: Mrkobrada, M., Hill, M. D., Chan, M. T. V., Sigamani, A., Cowan, D., Kurz, A., Sessler, D. I., Jacka, M., Graham, M., Dasgupta, M., Dunlop, V., Emery, D. J., Gulka, I., Guyatt, G., Heels-Ansdell, D., Murkin, J., Pettit, S., Sahlas, D. J., Sharma, M., Shar Tags: Clinical Practice Source Type: research

Intraoperative hypotension and perioperative acute ischemic stroke in patients having major elective non-cardiovascular non-neurological surgery
ConclusionOur analysis suggests that when MAP is less than 60  mmHg for more than 20 min, there is increased odds of acute ischemic stroke. Further studies are needed to determine what MAP should be targeted during surgery to optimize cerebral perfusion and limit ischemic stroke risk.
Source: Journal of Anesthesia - February 9, 2021 Category: Anesthesiology Source Type: research

Type of anaesthesia for acute ischaemic stroke endovascular treatment
CONCLUSIONS: In early outcomes, general anaesthesia improves target artery revascularisation compared to non-general anaesthesia with moderate-certainty evidence. General anaesthesia may improve adverse events (haemodynamic instability) compared to non-general anaesthesia with low-certainty evidence. We found no evidence of a difference in neurological impairment, stroke-related mortality, all intracranial haemorrhage and haemodynamic instability adverse events between groups with low-certainty evidence. We are uncertain whether general anaesthesia improves functional outcomes and time to revascularisation because the cert...
Source: Cochrane Database of Systematic Reviews - July 20, 2022 Category: General Medicine Authors: Renato Tosello Rachel Riera Giuliano Tosello Caroline Nb Clezar Jorge E Amorim Vladimir Vasconcelos Benedito B Joao Ronald Lg Flumignan Source Type: research