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High Expression of DEPDC1 Promotes Malignant Phenotypes of Breast Cancer Cells and Predicts Poor Prognosis in Patients With Breast Cancer
In this study, the immunohistochemistry results demonstrated that DEPDC1 was high-expressed in breast cancer tissues compared with the paired adjacent normal breast tissues, and its tendency at protein level was consistent with mRNA level from TCGA data. Moreover, DEPDC1 mRNA level revealed the strongest association with poor prognosis and development in breast cancer. In vitro assays showed that DEPDC1 overexpression resulted in significant promotion of proliferation by regulating cell cycle in MCF-7 cells, whilst an opposite effect was found in the MDA-MB-231 cells with DEPDC1 deletion. Notably, further investigation ind...
Source: Frontiers in Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research
Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research
The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
Conclusion and Perspectives
The IL-6/JAK/STAT signaling cascade plays a dominant role in skeletal muscle pathophysiology. IL-6 autocrine, paracrine, and endocrine functions assign to its downstream effectors pivotal importance in skeletal muscle-wasting-associated diseases and other multiple system diseases where muscle acts in communication with other organs. Targeting the components of the JAK/STAT pathway recently emerged as a strategic approach for the treatment of inflammatory diseases and human cancer.
This review highlights the opposite outcomes on muscle biology caused by the amount of local and systemic release ...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research
DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells
In conclusion, and in agreement with the other studies (Ford et al., 2007; Koh et al., 2015; Toy et al., 2015; Takai et al., 2018), our data suggest that during the acquisition of mesenchymal features, the level of full-length DDR1 expression should be considered, in addition to the other markers, as an important biomarker in the prognosis of aggressive breast carcinomas. As summarized in Figure 9, the regulation of cell proliferation and apoptosis by the collagen/DDR1 axis involves a differential activation of DDR1 signaling pathway and thus BIK expression. In the case of the basal-like bre...
Source: Frontiers in Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Source Type: research
Canonical Notch Signaling is Required for Bone Morphogenetic Protein ‐mediated Human Osteoblast Differentiation
BMP stimulation of bone ‐marrow derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMPinduced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induced os teoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow derived human mesenchymal stem cells (hMSC) can be induced by stimulation with either canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMP). However, it remains elusive how these two pathways lead to the ...
Source: Stem Cells - June 13, 2020 Category: Stem Cells Authors: Yadav Wagley,
Alessandra Chesi,
Parker K. Acevedo,
Sumei Lu,
Andrew D. Wells,
Matthew E. Johnson,
Struan F. A. Grant,
Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research
Canonical Notch signaling is required for bone morphogenetic protein ‐mediated human osteoblast differentiation
Bone morphogenetic protein (BMP) stimulation of bone ‐marrow‐derived human mesenchymal progenitor cells (hMSCs) increases Notch proteins via increased Notch ligand Jagged1 expression. Canonical Notch signaling is required for BMP‐induced ALPL expression and osteoblastic commitment of hMSCs. Both BMP‐induced osteoblastogenesis and Notch‐induc ed osteoblastogenesis require Runx2. AbstractOsteoblast differentiation of bone ‐marrow‐derived human mesenchymal stem cells (hMSC) can be induced by stimulation with canonical Notch ligand, Jagged1, or bone morphogenetic proteins (BMPs). However, it remains elusive how t...
Source: Stem Cells - June 23, 2020 Category: Stem Cells Authors: Yadav Wagley,
Alessandra Chesi,
Parker K. Acevedo,
Sumei Lu,
Andrew D. Wells,
Matthew E. Johnson,
Struan F. A. Grant,
Kurt D. Hankenson Tags: Tissue ‐Specific Stem Cells Source Type: research
Welcome the New RePORT and RePORTER Tools!
Ten years ago, NIH launched the RePORT (Research Portfolio Online Reporting Tools) website to serve as a one-stop shop for reports, data, and analyses of NIH research activities. Well, drum roll please, a new and modernized RePORT site as well as a faster and easier to use NIH RePORTER have now arrived.
The updated RePORT site strives to meet the needs of today’s users based on feedback received over the years. It is easier, simpler, and quicker to access the same information you have come to rely upon. Right from the homepage, for instance, you can jump into data with interactive charts that connect out to NIH Data Bo...
Source: NIH Extramural Nexus - October 13, 2020 Category: Research Authors: Mike Lauer Tags: blog Open Mike ExPORTER Funding data NIH Data Book RePORT RePORTER Source Type: funding
Training healthcare providers to respond to intimate partner violence against women
CONCLUSIONS: Overall, IPV training for HCPs may be effective for outcomes that are precursors to behaviour change. There is some, albeit weak evidence that IPV training may improve HCPs' attitudes towards IPV. Training may also improve IPV knowledge and HCPs' self-perceived readiness to respond to those affected by IPV, although we are not certain about this evidence. Although supportive evidence is weak and inconsistent, training may improve HCPs' actual responses, including the use of safety planning, identification and documentation of IPV in women's case histories. The sustained effect of training on these outcomes bey...
Source: Cochrane Database of Systematic Reviews - May 31, 2021 Category: General Medicine Authors: Naira Kalra Leesa Hooker Sonia Reisenhofer Gian Luca Di Tanna Claudia Garc ía-Moreno Source Type: research
Mitotherapeutix Awarded $2.2 Million SBIR Grant from the National...
siRNA Drug Candidates Suppress Novel NASH Target MCJ(PRWeb June 04, 2021)Read the full story at https://www.prweb.com/releases/mitotherapeutix_awarded_2_2_million_sbir_grant_from_the_national_institutes_of_health_for_sirna_nash_candidates/prweb17984798.htm
Source: PRWeb: Medical Pharmaceuticals - June 4, 2021 Category: Pharmaceuticals Source Type: news
Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis
CONCLUSIONS: There is currently insufficient evidence to determine the effect of ataluren as a therapy for people with CF with class I mutations. One trial reported favourable results for ataluren in a post hoc subgroup analysis of participants not receiving chronic inhaled aminoglycosides, but these were not reproduced in the later trial, suggesting that the earlier results may have occurred by chance. Future trials should carefully assess for adverse events, notably renal impairment, and consider the possibility of drug interactions. Cross-over trials should be avoided, given the potential for the treatment to change the...
Source: Cochrane Database of Systematic Reviews - March 3, 2023 Category: General Medicine Authors: Aisha A Aslam Ian P Sinha Kevin W Southern Source Type: research
A Systematic Comparison of Linear Regression –Based Statistical Methods to Assess Exposome-Health Associations
Conclusions: Correlation between exposures is a challenge for exposome research, and the statistical methods investigated in this study were limited in their ability to efficiently differentiate true predictors from correlated covariates in a realistic exposome context. Although GUESS and DSA provided a marginally better balance between sensitivity and FDP, they did not outperform the other multivariate methods across all scenarios and properties examined, and computational complexity and flexibility should also be considered when choosing between these methods.
Citation: Agier L, Portengen L, Chadeau-Hyam M, Basagaña X...
Source: EHP Research - December 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles December 2016 Source Type: research
Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis
We report many of them for the first time. For the already described citrullinated proteins MBP, GFAP, and vimentin, we could identify additional citrullinated sites. The number of modified proteins in MS white matter was higher than control tissue. Citrullinated peptides are considered neoepitopes that may trigger autoreactivity. We used newly identified epitopes and previously reported immunodominant myelin peptides in their citrullinated and non-citrullinated form to address the recognition of CSF-infiltrating CD4+ T cells from 22 MS patients by measuring proliferation and IFN-γ secretion. We did not detect ...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research
Ten things I wish I knew about Lane when I started my postdoc
by Arpi Siyahian PhD, Lane Library Bioresearch Informationist
1. Off-Campus Login for two weeks
On the librarys homepage at the top right-hand corner there is a link that reads Off Campus Login, visible only when you are off campus. Use that link to sign in; check the box that says keep me signed in for two weeks, and you will be able to access all Stanford resources as if you were on campus.
2. Different search options are available on Lanes website
Lane Search
The default search on the librarys homepage produces results from Pubmed, Scopus, and the librarys catalog. Click a title in Lane Search r...
Source: Lane News - October 6, 2011 Category: Databases & Libraries Source Type: news
7 strategies for funding med ed research
Studies show that medical education research suffers from a serious paucity of funding. As fewer institutions allocate dollars specifically for medical education projects, how can academic physicians ensure their innovative ideas find the financial support they deserve? Here are seven key strategies and resources to help.
Before writing a research proposal, physicians can take certain measures to make their search for funding more successful, according to a recent perspective article on medical education research in Academic Medicine. Some preliminary research steps the authors recommend include:
1. Looking in t...
Source: AMA Wire - December 11, 2015 Category: Journals (General) Authors: Troy Parks Source Type: news
