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10 What can we learn from the nervous sequelae of past pandemics?
Dr Mark Honigsbaum, medical historian and senior lecturer, City University of London. A regular contributor to The Observer & The Lancet, the author of five books including The Pandemic Century: One Hundred Years of Panic, Hysteria, and Hubris (New York and London: Norton; Hurst, 2019), The Fever Trail: In Search of the Cure for Malaria (Farrar Straus Giroux, 2002), and Living With Enza: The Forgotten Story of Britain and the Great Flu Pandemic of 1918 (Macmillan, 2009), which was longlisted for the Royal Society science book of the year in 2009. A specialist in the history of pandemics and infectious disease, his acad...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Honigsbaum, M. Tags: Speakers Short Biographies and Abstracts Source Type: research

Google ’s AI Lab, DeepMind, Offers ‘Gift to Humanity’ with Protein Structure Solution
Matt Higgins and his team of researchers at the University of Oxford had a problem. For years, they had been studying the parasite that spreads malaria, a disease that still kills hundreds of thousands of people every year. They had identified an important protein on the surface of the parasite as a focal point for a potential future vaccine. They knew its underlying chemical code. But the protein’s all-important 3D structure was eluding them. That shape was the key to developing the right vaccine to slide in and block the parasite from infecting human cells. [time-brightcove not-tgx=”true”] The team&rsqu...
Source: TIME: Science - July 28, 2022 Category: Science Authors: Billy Perrigo Tags: Uncategorized Artificial Intelligence biztech2030 Source Type: news

Corporate Efforts to Research and Develop Therapeutic Agents for Infectious Diseases That Threaten Human
Yakugaku Zasshi. 2022;142(7):691-696. doi: 10.1248/yakushi.21-00210-2.ABSTRACTOvercoming serious infectious diseases such as malaria, tuberculosis, and other neglected tropical diseases (NTDs) that threaten human life around the world is an important issue in global health. Most of these diseases are concentrated in developing and low-income countries, and in order to reinforce drug discovery activities, pharmaceutical companies are actively promoting industry-academia-government partnerships and utilizing funds to stimulate global health activities. In this presentation, three examples of our drug discovery activities are...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2022 Category: Drugs & Pharmacology Authors: Ryu Yoshida Rina Kaki Osamu Yoshida Takao Shishido Teruhisa Kato Yoshinori Yamano Source Type: research

Vaccines, Antibodies and Drug Libraries. The Possible COVID-19 Treatments Researchers Are Excited About
In early April, about four months after a new, highly infectious coronavirus was first identified in China, an international group of scientists reported encouraging results from a study of an experimental drug for treating the viral disease known as COVID-19. It was a small study, reported in the New England Journal of Medicine, but showed that remdesivir, an unapproved drug that was originally developed to fight Ebola, helped 68% of patients with severe breathing problems due to COVID-19 to improve; 60% of those who relied on a ventilator to breathe and took the drug were able to wean themselves off the machines after 18...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72�...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Why Science is Mistrusted
By, SAURABH JHA MD Recently, the Harvard Chan School of Public Health, in their press release, reported about the effect of surgical checklists in South Carolina. The release was titled, “South Carolina hospitals see major drop in post-surgical deaths with nation’s first proven statewide Surgical Safety Checklist Program.” The Health News Review, for which I review, grades coverage of research in the media. Based on their objective criteria, the Harvard press release would not score highly. The title exudes certainty – “nation’s first proven.” The study, not being a randomized controlled trial (RCT), though s...
Source: The Health Care Blog - April 22, 2017 Category: Consumer Health News Authors: at RogueRad Tags: Uncategorized Source Type: blogs

What Experts in Law and Medicine Have to Say About the Cost of Drugs
By ANDY ORAM Pharmaceutical drug costs impinge heavily on consumers’ consciousness, often on a monthly basis, and have become such a stress on the public that they came up repeatedly among both major parties during the U.S. presidential campaign–and remain a bipartisan rallying cry. A good deal of the recent conference named Health Law Year in P/Review, at the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School, covered issues with a bearing on drug costs. It’s interesting to take the academic expertise from that conference–and combine it with a bit of commo...
Source: The Health Care Blog - February 2, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Andy Oram Drug Pricing Pharma Source Type: blogs

Is Bill Gates a Humanitarian, Villain or Misguided Man?
Conclusion The Bill and Melinda Gates Foundation has donated money to 100 countries and the United States with their stated objective to improve education and world health. Investor Warren Buffet is a primary contributor to the foundation. Some of the foundation’s programs target schools, farmers, and sanitation needs, all worthy causes. One of their primary programs, with significant funding, has included vaccination programs focused on developing countries. These vaccine initiatives have resulted in documented deaths and injuries for thousands of previously healthy children. Are Melinda and Bill Gates simply misguided ...
Source: vactruth.com - July 16, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Top Stories Bill and Melinda Gates Foundation truth about vaccines Vaccine Death Source Type: blogs

Fight Aging! Newsletter, April 25th 2016
This study offers one useful data point, as the authors describe a genetic alteration that can boost the supply of new immune cells in old mice. The decline in that supply with age is one of the factors leading to poor immune function - and that means more than just vulnerability to infections, as the immune system is also responsible for destroying potentially cancerous and senescent cells, as well as clearing out forms of damaged proteins and unwanted metabolic waste. Various possibilities for increasing the number of new immune cells already exist in principle, such as regenerating the thymus, or cell therapies in which...
Source: Fight Aging! - April 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships
Publication date: Available online 19 September 2014 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Roopa Ramamoorthi , Katy M. Graef , Jennifer Dent Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of new drugs, vaccines, and diagnostics for these diseases by connecting the assets and resources of pharmaceutical companies, such as compound libraries and expertise, to academic or nonprofit researchers w...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 12, 2014 Category: Parasitology Source Type: research

Malaria: Hitches and Hopes.
Abstract Malaria, a devastating infectious disease caused by parasites of Plasmodium genera is transmitted from person to person through bites of infected mosquitoes. It generally traps underdeveloped nations with poor infrastructure and high population density. It has attracted considerable attention from academic institutions, pharmaceutical industries and government agencies but the efforts to eradicate this threat face a number of technical, economic, financial and institutional hurdles. In the absence of clinically proven vaccines to combat malaria,chemotherapy continues to be the best available option, altho...
Source: Mini Reviews in Medicinal Chemistry - April 28, 2014 Category: Chemistry Authors: Marella A, Verma G, Shaquiquzzaman M, Akhter M, Alam MM Tags: Mini Rev Med Chem Source Type: research