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Total 86 results found since Jan 2013.

Compensatory functional reorganization may precede hypertension-related brain damage and cognitive decline: a functional magnetic resonance imaging study
This article reports the results of functional MRI during a Stroop color interference task and structural evaluations based on a modified Fazekas scale. Results: No intergroup differences were found in regards to the severity of white matter lesions (Mann–Whitney U test = 150.5, P > 0.1), nor from the task performance in the scanner (t(35) = 0.2, P > 0.1). However, brain activation patterns between patients and controls varied. Hypertensive patients involved significantly more cerebral areas during the processing, regardless of the task difficulty. Differences were found in 26 diverse regions of both pri...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke and cognitive decline Source Type: research

Higher blood –brain barrier permeability is associated with higher white matter hyperintensities burden
This study aimed to investigate the relationship between BBB permeability and the severity of WMH burden. Consecutive participants without symptomatic stroke history presented for physical examination were recruited in this cross-sectional stud y and divided into three WMH burden groups according to total Fazekas scores. They received dynamic contrast-enhanced-magnetic resonance imaging to measure BBB permeability, and received Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). A total of 102 participants aged 4 9–90 years (mean age of 69.82 years) were enrolled (36 with low WMH burden, 35 w...
Source: Journal of Neurology - June 26, 2017 Category: Neurology Source Type: research

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

Vertebral Artery Dissection Masquerading as Concussion in an Adolescent
Conclusions Detailed history and thorough neurological examination in conjunction with appropriate imaging are necessary to distinguish between brainstem/cerebellar ischemia from vertebral artery dissection and concussion.
Source: Pediatric Emergency Care - May 1, 2018 Category: Emergency Medicine Tags: Illustrative Cases Source Type: research

Crossed aphasia following cerebral infarction in a right-handed patient with atypical cerebral language dominance
ConclusionThe findings suggest that the patient has right-sided cerebral language dominance, or that both hemispheres have linguistic functions. Not all patients show linguistic capabilities on the side opposite hand preference. The language dominance should be predicted by a combination of clinical manifestations and functional imaging techniques.
Source: Journal of Neurology - May 18, 2018 Category: Neurology Source Type: research

Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia
Conclusions In a community-dwelling non-demented population, we describe patterns of association between hippocampal subregions with cognition and risk of dementia. Specifically, the subiculum was associated with both poorer cognition and higher risk of dementia.
Source: NeuroImage - May 26, 2018 Category: Neuroscience Source Type: research

Carotid artery atherosclerosis:plaque imaging in the personalized-medicine era
Conclusion: The evolution of atherosclerosis imaging and the emergence of new methods to measure atherosclerotic plaque vulnerability, particularly in the field of molecular imaging, have provided new insights into the pathophysiology of atherosclerosis and can be utilized in drug discovery and efficacy trials.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Gharavi, M., Saboury, B., Werner, T., Alavi, A. Tags: Educational Exhibits Source Type: research

Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging
ObjectiveRecent availability of amyloid and tau positron emission tomography (PET) has provided us with a unique opportunity to measure the association of systemic vascular health with brain health after accounting for the impact of Alzheimer disease (AD) pathologies. We wanted to quantify early cerebrovascular health –related magnetic resonance imaging brain measures (structure, perfusion, microstructural integrity) and evaluate their utility as a biomarker for cerebrovascular health.MethodsWe used 2 independent samples (discovery, n  = 390; validation, n = 1,035) of individuals, aged ≥ 60 years, along the...
Source: Annals of Neurology - October 25, 2018 Category: Neurology Authors: Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, Jonathan Graff ‐Radford, Robert I. Reid, Val J. Lowe, Samantha M. Zuk, Matthew L. Senjem, Christopher G. Schwarz, Jeffrey L. Gunter, Kejal Kantarci, Mary M. Machulda, Michelle M. Mi Tags: Research Article Source Type: research

Right hippocampus atrophy is independently associated with Alzheimer's disease with psychosis
ConclusionWe found that more severe hippocampal atrophy is associated with AD+P than with AD −P. In addition, atrophy of the right hippocampus remained significant among AD+P after adjustment for frontal volume. These findings suggest that right hippocampal atrophy is independently associated with AD+P.
Source: Psychogeriatrics - November 14, 2018 Category: Geriatrics Authors: Kangyoon Lee, Young Min Lee, Je ‐Min Park, Byung‐Dae Lee, Eunsoo Moon, Hee‐Jeong Jeong, Soo Yeon Kim, Young‐In Chung, Ji‐Hoon Kim Tags: ORIGINAL ARTICLE Source Type: research

Collectivism Is Associated With Greater Neurocognitive Fluency in Older Adults
This study aimed to evaluate the impact of self-construal on neurocognitive functions in older adults. A total of 86 community-dwelling older adults 60 years and older were assessed with three common self-report measures of self-construal along individualism and collectivism (IC). A cognitive battery was administered to assess verbal and non-verbal fluency abilities. Latent profile analysis (LPA) was used to categorize individuals according to IC, and one-way analyses of covariance (ANCOVA), including relevant covariates (e.g., ethnicity, gender, linguistic abilities), were used to compare neurocognitive functions between ...
Source: Frontiers in Human Neuroscience - April 10, 2019 Category: Neuroscience Source Type: research

Transcranial Direct Current Stimulation Use in Warfighting: Benefits, Risks, and Future Prospects
Conclusion The aim of this paper was to examine whether military tDCS use can be efficacious and ethical in military settings. Our assessment is that tDCS offers a number of cognitive, motor, and perceptual enhancement opportunities which could provide value in military situations like training and operations. There is potential scope for use in a number of key areas that directly affect practical battlefield advantage and survivability, such as deceptive capabilities, risk-taking, threat detection, perception, and physiological improvement. Additionally, tDCS has the potential to improve command and control decision maki...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research

Modulating Applied Task Performance via Transcranial Electrical Stimulation
Conclusion tES may prove valuable for modulating applied task performance, though research in this area warrants careful consideration of several individual-, context-, and task-related factors that may predict the robustness and directionality of tES effects. Whereas most applied research with tES has administered tDCS, tACS and tRNS have also shown potential to modulate cortical activity and behavior. Even in highly applied and dynamic tasks, such as navigation and driving, tES appears to carry some performance benefits. This is compelling because as tES is slowly incorporated into highly complex real-world environments...
Source: Frontiers in Human Neuroscience - April 29, 2019 Category: Neuroscience Source Type: research

Lifestyle Risk Factors and Findings on Brain Magnetic Resonance Imaging of Older Adult American Indians: The Strong Heart Study
Conclusions: This study found similar associations between smoking and vascular brain injury among American Indians, as seen in other populations. In particular, these findings support the role of smoking as a key correlate for cerebral atrophy.Neuroepidemiology
Source: Neuroepidemiology - June 4, 2019 Category: Epidemiology Source Type: research

Potential applications of FDG-PET/MRI in detecting vascular dementia
Conclusions: FDG-PET/MRI may be a valuable tool in the diagnosis of VaD. However, the paucity of data in the field necessitates a further analysis of its similarity to FDG-PET/CT in results. Novel studies should be conducted to explore various scanners, patient populations, and MRI protocols to better inform the identification of VaD.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Bhattaru, A., Zhang, V., Hancin, E., Borja, A., Rojulpote, K. V., Werner, T., Revheim, M.-E., Alavi, A. Tags: Educational Exhibits Poster Session I Source Type: research

Associations of Blood Pressure and Carotid Flow Velocity with Brain Volume and Cerebral Small Vessel Disease in a Community-Based Population
AbstractCerebral small vessel disease (CSVD) is a common finding on brain magnetic resonance imaging (MRI). We previously demonstrated that high blood pressure (BP) and low carotid flow velocity were associated with cerebrovascular disease. However, their associations with brain volume and CSVD remain to be determined. A total of 721 adults ( ≥ 50 years) from the community-based I-Lan Longitudinal Aging Study were included. Flow velocities at the common (CCA) and internal carotid artery (ICA), including peak systolic velocity (PSV) and end-diastolic velocity (EDV), were measured with Doppler ultrasound. We further det...
Source: Translational Stroke Research - July 31, 2020 Category: Neurology Source Type: research