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Total 186 results found since Jan 2013.

Prolonged transesophageal echocardiography during percutaneous closure of the left atrial appendage without general anesthesia: the utility of the Janus mask
Conclusion Deep sedation with noninvasive ventilation may be a reasonable and safe alternative to general endotracheal anesthesia in patients requiring prolonged TEE for noninvasive cardiac procedures, including LAA closure.
Source: Canadian Journal of Anesthesia - July 8, 2016 Category: Anesthesiology Source Type: research

Superselective Provocative Test with Propofol Using Motor-Evoked Potential Monitoring for Managing Cerebral Arteriovenous Malformations Fed by the Anterior Choroidal Artery
We report the case of a 57-year-old man who developed an intracerebral hematoma in the left internal temporal lobe and who had an AVM with a varix in the ambient cistern, which was primarily fed by a branch of the left anterior choroidal artery (AChA) and the posterior lateral choroidal artery, and drained into the basal vein.
Source: Journal of Stroke and Cerebrovascular Diseases - June 14, 2016 Category: Neurology Authors: Makoto Isozaki, Tetsu Satow, Toshinori Matsushige, Hisae Mori, Koji Iihara Tags: Case Studies Source Type: research

Status epilepticus: Refractory and super-refractory
Deepanshu Dubey, Jayantee Kalita, Usha K MisraNeurology India 2017 65(7):12-17Status epilepticus (SE) is an important neurological emergency. It is defined as seizures lasting for 5 minutes or more or recurrent seizures without recovery of consciousness to baseline between the attacks. Refractory SE (RSE) is defined as SE persisting despite sufficient dose of benzodiazepines and at least one antiepileptic drug (AED), irrespective of time. Super refractory SE (SRSE) is defined as SE that continues for 24 hours or more after the use of anesthetic therapy, including cases that recur on weaning of the anesthestic agent. RSE oc...
Source: Neurology India - March 7, 2017 Category: Neurology Authors: Deepanshu Dubey Jayantee Kalita Usha K Misra Source Type: research

Lactate/pyruvate monitoring during carotid endarterectomy under general anaesthesia versus cervical plexus block: A randomised controlled study
Conclusion: In patients undergoing Carotid endarterectomy, serum levels of both lactate and pyruvate were higher under general versus regional anaesthesia.
Source: Indian Journal of Anaesthesia - May 9, 2017 Category: Anesthesiology Authors: Gomaa Z Hussien Ahmed M Elbadawy Hossam A Elshamaa Source Type: research

Propofol-Induced Hypertriglyceridemia as a Cause of Stroke
None
Source: Journal of Clinical Lipidology - May 1, 2017 Category: Lipidology Authors: Matthew Weiss Source Type: research

Propofol Attenuates Inflammatory Response in LPS-Activated Microglia by Regulating the miR-155/SOCS1 Pathway
This study explored the anti-inflammatory effects of propofol in LPS-activated BV2 microglia. Propofol potently decreased the pro-inflammatory mediators, such as nitric oxide, TNF- α, and IL-6, at both the transcriptional and translational levels. Furthermore, propofol suppressed the expression of miR-155 in LPS-activated cells. Knockdown of miR-155 attenuated the anti-inflammatory effect of propofol in cells after LPS exposure. miR-155 was also confirmed as a negative regula tor of SOCS1 expression. The inhibitory effect of propofol on LPS-induced inflammation involved the upregulation of SOCS1. Overall, these results su...
Source: Inflammation - September 5, 2017 Category: Allergy & Immunology Source Type: research

Maternal and fetal effects of dexmedetomidine infusion in pregnant ewes anesthetized with sevoflurane.
CONCLUSIONS AND CLINICAL RELEVANCE Pregnant ewes receiving a combination of sevoflurane and an infusion of dexmedetomidine without a loading dose had cardiac index in acceptable ranges and maintained normoxia. This balanced anesthesia did not produce significant changes in fetal blood pressure or heart rate. However, the increase in fetal plasma lactate concentration and changes in maternal pulmonary vascular resistance and uterine blood flow require further investigation to better elucidate these effects. PMID: 29076367 [PubMed - in process]
Source: American Journal of Veterinary Research - October 28, 2017 Category: Veterinary Research Authors: Lépiz ML, Sayre R, Sawant O, Barr J, Pashmakova M, Washburn K, Washburn S Tags: Am J Vet Res Source Type: research

Total Intravenous Versus Volatile Induction and Maintenance of Anesthesia in Elective Carotid Endarterectomy: Effects on Cerebral Oxygenation and Cognitive Functions
Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD.
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 2, 2018 Category: Anesthesiology Authors: Vsevolod V. Kuzkov, Maxim Y. Obraztsov, Oleg Y. Ivashchenko, Nadezhda Y. Ivashchenko, Valery M. Gorenkov, Mikhail Y. Kirov Tags: Original Article Source Type: research

Effect of different analgesic techniques on hemodynamic variables recorded with an esophageal Doppler monitor during ovariohysterectomy in dogs.
This study compared the efficacy of intravenous (IV) fentanyl and ketamine with lumbosacral epidural lidocaine in dogs undergoing ovariohysterectomy. Dogs with esophageal Doppler monitoring (n = 112) were included in this retrospective study. All dogs were premedicated with dexmedetomidine and methadone, induced with IV propofol or alfaxalone and maintained using isoflurane and IV fentanyl, IV ketamine, or epidural lidocaine. Heart rate (HR), mean arterial pressure (MAP), expired fraction of isoflurane (ETIso), stroke distance (SD), minute distance (MD), peak velocity (PV) and mean acceleration (MA) were recorded before an...
Source: The Canadian Veterinary Journal - April 1, 2018 Category: Veterinary Research Authors: Sández I, Soto M, Torralbo D, Rioja E Tags: Can Vet J Source Type: research

Total Intravenous Versus Volatile Induction and Maintenance of Anesthesia in Elective Carotid Endarterectomy: Effects on Cerebral Oxygenation and Cognitive Functions
Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD.
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 2, 2018 Category: Anesthesiology Authors: Vsevolod V. Kuzkov, Maxim Y. Obraztsov, Oleg Y. Ivashchenko, Nadezhda Y. Ivashchenko, Valery M. Gorenkov, Mikhail Y. Kirov Tags: Original Article Source Type: research

Evaluation of Propofol in Comparison with Other General Anesthetics for Surgery in Children Younger than 3 Years: a Systematic Review and Meta-Analysis.
CONCLUSION: This systematic review and meta-analysis indicates that propofol use for general anesthesia in young healthy children undergoing surgery does not increase complications and that propofol could be at least comparable to other anesthetic agents. PMID: 31001938 [PubMed - in process]
Source: Journal of Korean Medical Science - April 20, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Pharmacodynamic Analysis of the Influence of Propofol on Left Ventricular Long-Axis Systolic Performance in Cardiac Surgical Patients.
CONCLUSION: Propofol reduces LV systolic long-axis performance in a dose-dependent manner. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01826149. PMID: 31020819 [PubMed - in process]
Source: Journal of Korean Medical Science - April 26, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Neuroanesthesia and outcomes: evidence, opinions, and speculations on clinically relevant topics
The objective of this review is to identify outstanding topics most relevant to neuroanesthesia practice and patient outcomes. We discuss the role of awake craniotomy, choice of general anesthetic agents, monitoring of anesthetic ‘depth’, mannitol-induced diuresis, neurophysiological monitoring, hyperventilation, and cerebral hypoperfusion. Recent findings Awake craniotomy, although a technique likely underused, is associated with enhanced recovery after surgery and prolonged survival after brain tumor resection compared with surgery under general anesthesia. The choice of general anesthetic must balance patient and...
Source: Current Opinion in Anaesthesiology - August 30, 2019 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Lingzhong Meng Source Type: research

Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway
Background: Our previous study showed that propofol, one of the widely used anesthetic agents, can attenuate subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) via inhibiting inflammatory and oxidative reaction. However, it is perplexing whether propofol attenuates inflammatory and oxidative reaction through modulating PI3K/Akt pathway. The present study investigated whether PI3K/Akt pathway is involved in propofol's anti-inflammation, antioxidation, and neuroprotection against SAH-induced EBI.
Source: Journal of Stroke and Cerebrovascular Diseases - October 3, 2019 Category: Neurology Authors: Hua-bin Zhang, Xian-kun Tu, Quan Chen, Song-sheng Shi Source Type: research

Comparison of the effect of propofol and desflurane on S-100β and GFAP levels during controlled hypotension for functional endoscopic sinus surgery: A randomized controlled trial
Conclusion: On comparing the effects of propofol and desflurane anesthesia for controlled hypotension on the levels of S-100β and GFAP, we noted that there was no significant difference in S-100β and GFAP levels between the 2 study groups. Clinical trial registration: Available at: http://cris.nih.go.kr, KCT0002698.
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research