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Total 128 results found since Jan 2013.

Adsorptive stripping voltammetric determination of carbofuran in food using novel type of modified carbon-based electrode with grafted layers of nickel
Talanta. 2023 Aug 23;267:125116. doi: 10.1016/j.talanta.2023.125116. Online ahead of print.ABSTRACTA voltammetric determination of carbofuran (CBF) was developed using a novel type of carbon-containing electrode (CCE) modified with carbon ink (CI) and a chromatographic sorbent (CS) based of chromaton (Ch), polyethylene glycol and nickel acetylacetonate with grafted layers of nickel (NiCS, stands for Ni modified CS) further denoted as CI/NiCS/CCE. The surface morphology of this modified electrode was investigated by scanning electron microscopy (SEM) and by electrochemical impedance spectroscopy (EIS). CBF which is not elec...
Source: Talanta - September 15, 2023 Category: Chemistry Authors: A N Solomonenko E V Dorozhko J Barek E I Korotkova V O Semin A V Erkovich N V Aseeva Source Type: research

Unveiling pro-angiogenesis and drug delivery using dual-bio polymer with bio-ceramic based nanocomposite hydrogels
Chemosphere. 2023 Sep 8:140131. doi: 10.1016/j.chemosphere.2023.140131. Online ahead of print.ABSTRACTIn regenerative medicine, blood vessel development is of utmost importance as it enables the restoration of blood flow to tissues, and facilitate rapid vascularization in clinical tissue-engineered grafts. Herein, we fabricate the nanocomposite hydrogels from BG, alginate, Polyethylene glycol (PEG) and Dexamethasone (DEX) for the dual applications of drug delivery and angiogenesis assay. The hydrogels were fabricated through cross-linking approach and termed as alginate/PEG (A), alginate/PEG/clinophosinaite (AC), and algin...
Source: Chemosphere - September 10, 2023 Category: Chemistry Authors: K Elakkiya P Bargavi S Balakumar Source Type: research

Ferrocene/ β-cyclodextrin based supramolecular nanogels as theranostic systems
Biomed Pharmacother. 2023 Aug 31;166:115402. doi: 10.1016/j.biopha.2023.115402. Online ahead of print.ABSTRACTA supramolecular redox responsive nanogel (NG) with the ability to sense cancer cells and loaded with a releasing therapeutic agent was synthesized using hostguest interactions between polyethylene glycol-grafted-β-cyclodextrin and ferrocene boronic acid. Cyclic voltammetry matched with other spectroscopy and microscopy methods provided strong indications regarding host-guest interactions and formation of the NG. Moreover, the biological properties of the NG were evaluated using fluorescence silencing, confocal la...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Khadijeh Soleimani Siamak Beyranvand Zeinab Souri Zainab Ahmadian Abdollah Yari Abbas Faghani Azim Shams Mohsen Adeli Source Type: research

Loratadine oral bioavailability enhancement via solid dispersion loaded oro-dispersible films: Formulation, characterization and pharmacokinetics
Colloids Surf B Biointerfaces. 2023 Aug 25;230:113526. doi: 10.1016/j.colsurfb.2023.113526. Online ahead of print.ABSTRACTLoratadine (LRD) belongs to second-generation tricyclic H1 antihistamine class, known for its non-sedating properties in allergic reactions. H1 antihistamines avoid and block the responses to allergens or histamine in nose and conjunctivae, thereby abolishing itching, congestion and sneezing. LRD is a Biopharmaceutical Class System (BCS) class II drug with dissolution or solubility limited absorption which limited the oral bioavailability and therapeutic efficacy of LRD. To improve the oral bioavailabil...
Source: Colloids and Surfaces - August 30, 2023 Category: Biotechnology Authors: Nayyer Islam Naveed Ullah Khan Anam Razzaq Farid Menaa Zaheer Ullah Khan Abid Hussain Saif Ur Rehman Haroon Iqbal Jiang Ni Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tailoring the release of drugs having different water solubility by hybrid polymer-lipid microparticles with a biphasic structure
Eur J Pharm Biopharm. 2023 Jul 28:S0939-6411(23)00199-6. doi: 10.1016/j.ejpb.2023.07.017. Online ahead of print.ABSTRACTThe aim of this study is to investigate the potential of hybrid polymer-lipid microparticles with a biphasic structure (b-MPs) as drug delivery system. Hybrid b-MPs of Compritol®888 ATO as main lipid constituent of the shell and polyethylene glycol 400 as core material were produced by an innovative solvent-free approach based on spray congealing. To assess the suitability of hybrid b-MPs to encapsulate various types of APIs, three model drugs (fluconazole, tolbutamide and nimesulide) with extremely diff...
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 30, 2023 Category: Drugs & Pharmacology Authors: Serena Bertoni Beatrice Albertini Joanna Ronowicz-Pilarczyk Nadia Passerini Source Type: research

Development of κ-carrageenan-PEG/lecithin bioactive hydrogel membranes for antibacterial adhesion and painless detachment
Int J Biol Macromol. 2023 Jul 10:125789. doi: 10.1016/j.ijbiomac.2023.125789. Online ahead of print.ABSTRACTThe issue of wound dressing adherence poses a substantial challenge in the field of wound care, with implications both clinically and economically. Overcoming this challenge requires the development of a hydrogel dressing that enables painless removal without causing any secondary damage. However, addressing this issue still remains a significant challenge that requires attention and further exploration. The present study is focused on the synthesis of hydrogel membranes based on κ-carrageenan (CG), polyethylene gly...
Source: International Journal of Biological Macromolecules - July 12, 2023 Category: Biochemistry Authors: Pratibha Singh Chetna Verma Amlan Gupta Samrat Mukhopadhyay Bhuvanesh Gupta Source Type: research

Polymeric Networks Derived from UV-Curing of Bio-Based Polyesters for Methyl Violet Removal
In this study, firstly, the syntheses and characterizations of biobased polyesters with different acid values obtained from the condensation reaction of biobased itaconic acid and polyethylene glycol were investigated. Then, UV curing was applied to form polymeric networks as adsorbent material from these polyesters containing different acids. Fourier transform infrared spectrometry (FTIR), Nuclear Magnetic Resonance Spectroscopy (NMR), X-ray Photoelectron Spectroscopy (XPS), Gel Permeation Chromatography (GPC) and scanning electron microscope (SEM) were used for the characterization of polymeric networks. The effects of t...
Source: Environmental Science and Pollution Research International - July 7, 2023 Category: Environmental Health Authors: Elif Cerraho ğlu Kaçakgil Aleyna Turanl ı Cemil Dizman Source Type: research

Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery
Biomacromolecules. 2023 Jun 12. doi: 10.1021/acs.biomac.3c00265. Online ahead of print.ABSTRACTProtease-responsive multi-arm polyethylene glycol-based microparticles with biscysteine peptide crosslinkers (CGPGG↓LAGGC) were obtained for intradermal drug delivery through inverse suspension photopolymerization. The average size of the spherical hydrated microparticles was ∼40 μm after crosslinking, making them attractive as a skin depot and suitable for intradermal injections, as they are readily dispensable through 27G needles. The effects of exposure to matrix metalloproteinase 9 (MMP-9) on the microparticles were eval...
Source: Biomacromolecules - June 12, 2023 Category: Biochemistry Authors: Heidi K Noddeland Marianne Lind Karsten Petersson Frank Caruso Martin Malmsten Andrea Heinz Source Type: research