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Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Approach to the Patient: Pharmacological therapies for fracture risk reduction in adults with osteogenesis imperfecta
CONCLUSION: Fracture rates are elevated in adults with OI. Although clinical trial data are limited, bisphosphonates and teriparatide may be useful in improving BMD. Further research is needed to develop medications for adults with OI that will lead to definite fracture rate reduction.PMID:36658750 | DOI:10.1210/clinem/dgad035
Source: The Journal of Clinical Endocrinology and Metabolism - January 20, 2023 Category: Endocrinology Authors: Winnie Liu Brendan Lee Sandesh C S Nagamani Lindsey Nicol Frank Rauch Eric T Rush V Reid Sutton Eric Orwoll Source Type: research
Clomiphene citrate for male infertility: A systematic review and meta ‐analysis
ConclusionsClomiphene citrate increased sperm concentration and -motility and could be considered as a safe therapy for improving sperm parameters in infertile males.This article is protected by copyright. All rights reserved
Source: Andrology - January 22, 2023 Category: Urology & Nephrology Authors: M. Huijben,
R.L.N. Huijsmans,
M.T.W.T Lock,
V.F. Kemp,
L.M.O. Kort,
H.M.K Breda Tags: REVIEW ARTICLE Source Type: research
Approach to the Patient: Pharmacological therapies for fracture risk reduction in adults with osteogenesis imperfecta
CONCLUSION: Fracture rates are elevated in adults with OI. Although clinical trial data are limited, bisphosphonates and teriparatide may be useful in improving BMD. Further research is needed to develop medications for adults with OI that will lead to definite fracture rate reduction.PMID:36658750 | DOI:10.1210/clinem/dgad035
Source: The Journal of Clinical Endocrinology and Metabolism - January 20, 2023 Category: Endocrinology Authors: Winnie Liu Brendan Lee Sandesh C S Nagamani Lindsey Nicol Frank Rauch Eric T Rush V Reid Sutton Eric Orwoll Source Type: research
Ormeloxifene, a selective estrogen receptor modulator, protects against pulmonary hypertension
CONCLUSION: This study demonstrates that ormeloxifene promoted pulmonary 17β-estradiol synthesis, alleviated inflammation, improved the NOX4/HO1/Nrf/PPARγ/PGC-1α axis, and attenuated pulmonary hypertension. It is evidently safe at tested concentrations and may be effectively repurposed for pulmonary hypertension treatment.PMID:36731722 | DOI:10.1016/j.ejphar.2023.175558
Source: European Journal of Pharmacology - February 2, 2023 Category: Drugs & Pharmacology Authors: Adam Olaitan Abdulkareem Priya Tiwari Zahid Rasool Lone Hina Iqbal Satish Gupta Rajesh Kumar Jha Debabrata Chanda Kumaravelu Jagavelu Kashif Hanif Source Type: research
The effect of 17beta-estradiol plus norethisterone acetate on anthropometric indices: A systematic review and meta-analysis of randomized controlled trials
CONCLUSION: Administration of 17beta-estradiol plus norethisterone acetate for more than 3 months results in a decrease in BMI, which helps to reduce cardiovascular disease risk.PMID:37364427 | DOI:10.1016/j.ejogrb.2023.06.019
Source: Reproductive Biology - June 26, 2023 Category: Reproduction Medicine Authors: Yushan Li Xiao Chen Xingji Gong Dongyong He Xi Cheng Kousalya Prabahar Benjamin Hern ández-Wolters Periyannan Velu Wenjie Du Source Type: research
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Making sense of your IVF ovarian stimulation treatment protocols
Diagram of the time Menstrual Cycle a - follicle b - maturing follicle c - ovulation d - corpus luteum e - degenerate corpus luteum H O - ovarian histology T - body temperature O L - luteinizing hormone O P - progesterone hormone O E - estradiol hormone O F-S - follicle-stimulating hormone F - follicular phase O - ovulation L - luteal phase M - menstruation E - endometrial histology
Let's start with the basics ! Why do we need to stimulate your ovaries for IVF in the first place ?Your ovaries are the reservoir for your eggs. Eggs are the cells which carry half of the information (genetic blue print) necessary for cr...
Source: The Patient's Doctor - January 7, 2013 Category: Obstetricians and Gynecologists Tags: Luteinizing hormone In vitro fertilisation Follicle-stimulating hormone AMH Antral follicle Gonadotropin-releasing hormone FSH Anti-Müllerian hormone Source Type: blogs
Hormonal contraceptives and venous thromboembolism: An epidemiological update
In conclusion, newer generation formulations of hormonal contraceptives, as well as the non-oral hormonal contraceptive, seem to be more thrombogenic than second generation hormonal contraceptives.
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - February 1, 2013 Category: Endocrinology Authors: Genevieve Plu-Bureau, Lorraine Maitrot-Mantelet, Justine Hugon-Rodin, Marianne Canonico Source Type: research
Estrogen induce VEGF expression in dermal papilla cells
It is required to reveal the mechanisms of female pattern hair loss (FPHL) augmenting in Japanese women with age. Estrogen could have a pivotal role on the hair cycle control, because anagen extends during pregnancy. Estrogen levels in blood considerably drop in women who are in ages suffering FPHL. Therefore, we analyzed expressions of several genes associated with hair cycles using real time RT-PCR in human follicular dermal papilla cells (DPCs) after treatment with a various extent of estradiol. The cells were culture with serum-free medium without phenol red. We found that vascular endothelial growth factor (VEGF) expr...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yuuki Sakurai, Ichitaro Niibe, Satoshi Ogawa, Yasufumi Takeda, Takashi Matsuzaki Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research
Disorder of sexual development in a Yorkshire terrier (78, XY; SRY-positive).
Abstract
A 9-month-old Yorkshire terrier was admitted to the clinic because of abnormal sexual behaviour and clitoral hypertrophy. External examination confirmed standard development of caudal genital organs: vagina, vulva and cervix uteri. Serum profile of gonadotropin hormones 17 β-estradiol (<10.0 pg.ml(-1)) and testosterone (9.1 ng.ml(-1)) revealed the presence of testicular tissue. A midline laparotomy was performed to detect the cranial parts of the genital system. Gonads resembling testicles, structures indicating epididymis and rudimentary deferent ducts were resected, along with adherent part of the...
Source: J Appl Genet - February 2, 2013 Category: Genetics & Stem Cells Authors: Dianovský J, Holečková B, Hajurka J, Siviková K, Cigánková V Tags: J Appl Genet Source Type: research
Effect of missed combined hormonal contraceptives on contraceptive effectiveness: a systematic review
Conclusion: Most of the studies in this evidence base relied on surrogate measures of pregnancy risk and ranged in quality. For studies providing indirect evidence on the effects of missed CHCs, it is unclear how differences in surrogate measures correspond to pregnancy risk. Fewer studies examined the transdermal patch and vaginal ring than combined oral contraceptives.
Source: Contraception - October 22, 2012 Category: OBGYN Authors: Lauren B. Zapata, Maria W. Steenland, Dalia Brahmi, Polly A. Marchbanks, Kathryn M. Curtis Tags: Review Articles Source Type: research
