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Post-stroke treatment with 17 β-estradiol exerts neuroprotective effects in both normotensive and hypertensive rats
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Wendy Stoop, Deborah De Geyter, Sofie Verachtert, Sofie Brouwers, Peggy Verdood, Jacques De Keyser, Ron Kooijman Although ischemic stroke is a major cause of death worldwide and the predominant cause of acquired disability, the only effective drug therapy that has been developed thus far is reperfusion by tissue plasminogen activator. Since most patients do not qualify for this treatment, new methods have to be developed. It is well known that estradiol (E2) exerts neuroprotective effects in different models of cerebral ischemia, but post-stroke tr...
Source: Neuroscience - March 15, 2017 Category: Neuroscience Source Type: research

The loss of estrogen efficacy against cerebral ischemia in aged postmenopausal female mice
Publication date: 13 January 2014 Source:Neuroscience Letters, Volume 558 Author(s): Min Cai , Yu-Long Ma , Pei Qin , Yan Li , Li-Xia Zhang , Huang Nie , Zhengwu Peng , Hui Dong , Hai-Long Dong , Wu-Gang Hou , Li-Ze Xiong Estrogen has been shown to have neuroprotective effects in numerous experimental studies involving young and adult animals. However, several clinical trials have found that in aged postmenopausal women who received estrogen replacement therapy, there did not appear to be a reduction in the incidence of stroke. The aim of this study was to investigate the effects of physiological dosages of estrogen on a...
Source: Neuroscience Letters - November 4, 2014 Category: Neuroscience Source Type: research

Periodic Estrogen Receptor-Beta Activation: A Novel Approach to Prevent Ischemic Brain Damage.
Abstract In women, the risk for cerebral ischemia climbs rapidly after menopause. At menopause, production of ovarian hormones; i.e., progesterone and estrogen, slowly diminishes. Estrogen has been suggested to confer natural protection to premenopausal women from ischemic stroke and some of its debilitating consequences. This notion is also strongly supported by laboratory studies showing that a continuous chronic 17β-estradiol (E2; a potent estrogen) regimen protects brain from ischemic injury. However, concerns regarding the safety of the continuous intake of E2 were raised by the failed translation to the cli...
Source: Neurochemical Research - June 7, 2014 Category: Neuroscience Authors: Cue L, Diaz F, Briegel KJ, Patel HH, Raval AP Tags: Neurochem Res Source Type: research

Comparative Analysis of Gonadal Steroid-Mediated Neuroprotection after Transient Focal Ischemia in Rats: Route of Application and Substrate Composition
Abstract Progesterone (P) and 17ß-estradiol (E2) mitigate neuronal damage after experimentally induced traumatic brain injury (TBI) and ischemic stroke. Fish oil components such as omega-3 polyunsaturated fatty acids (PUFA n3) also provide neuroprotection in these traumatic models. Steroids and PUFA n3 dampen neuroinflammatory processes and regulate glial function in the affected brain areas. Using a transient focal ischemic rat model, we demonstrate that the co-application of PUFA n3 and P/E2 and the choice of the application route have a clear impact on the prevention of ischemia-induced infarct volume and beha...
Source: Journal of Molecular Neuroscience - November 21, 2014 Category: Neuroscience Source Type: research

SIRT1-dependent AMPK pathway in the protection of estrogen against ischemic brain injury.
CONCLUSION: Our data support that estrogen protects against ischemic stroke through preventing neuron death via the SIRT1-dependent AMPK pathway. PMID: 28256111 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - March 1, 2017 Category: Neuroscience Authors: Guo JM, Shu H, Wang L, Xu JJ, Niu XC, Zhang L Tags: CNS Neurosci Ther Source Type: research

Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor- α
In conclusion, the results of the present study suggest miR-181a inhibition enhances E2-mediated stroke protection in females in part by augmenting ERα production, a mechanism detected in female mice and female astrocytes. Sex differences were observed with combined miR-181a inhibition/E2 treatment, and miR-181a targeting of ERα. Graphical abstract
Source: Molecular and Cellular Neuroscience - May 15, 2017 Category: Neuroscience Source Type: research

G protein ‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
In this study, we also demonstrate that selective activation of GPER induced astrocyte apoptosis via the phospholipase C pathway and subsequent intracellular calcium rise, whereas in neurons, this effect was not observed. Taken together, this evidence supports a direct impact of GPER activity on the viability of astrocytes, which seems to be associated with the regulation of different signaling pathways in astrocytes and neurons.
Source: Journal of Neurochemistry - January 28, 2019 Category: Neuroscience Authors: Cl áudio Roque, Julieta Mendes‐Oliveira, Graça Baltazar Tags: Original Article Source Type: research

GPER1 mediates estrogen-induced neuroprotection against oxygen-glucose deprivation in the primary hippocampal neurons
Publication date: 22 July 2016 Source:Neuroscience, Volume 328 Author(s): Tian-Zhi Zhao, Fei Shi, Jun Hu, Shi-Ming He, Qian Ding, Lian-Ting Ma It is well-known that the neuroprotective effects of estrogen have potential in the prevention and amelioration of ischemic and degenerative neurological disorders, while the underlying mechanisms for estrogen actions are undefined. As an important mediator for the non-genomic functions of estrogen, GPER1 (G Protein-coupled Estrogen Receptor 1) has been suggested to involve in the beneficial roles of estrogen in neural cells. Here our studies on primary hippocampal neurons h...
Source: Neuroscience - May 12, 2016 Category: Neuroscience Source Type: research

G protein ‐coupled estrogen receptor activates cell type specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - December 20, 2018 Category: Neuroscience Authors: C Roque, J. Mendes ‐Oliveira, G. Baltazar Tags: Original Article Source Type: research

Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils
ConclusionsICV thrombin injection induced more severe ventricular dilation and white matter damage in female rats compared to males. Estrogen appears to contribute to this difference which may involve greater neutrophil infiltration in females. Understanding sex differences in thrombin-induced brain injury may shed light on future interventions for hemorrhagic stroke.
Source: Fluids and Barriers of the CNS - August 16, 2021 Category: Neuroscience Source Type: research