G protein ‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes

In this study, we also demonstrate that selective activation of GPER induced astrocyte apoptosis via the phospholipase C pathway and subsequent intracellular calcium rise, whereas in neurons, this effect was not observed. Taken together, this evidence supports a direct impact of GPER activity on the viability of astrocytes, which seems to be associated with the regulation of different signaling pathways in astrocytes and neurons.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research