Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils

ConclusionsICV thrombin injection induced more severe ventricular dilation and white matter damage in female rats compared to males. Estrogen appears to contribute to this difference which may involve greater neutrophil infiltration in females. Understanding sex differences in thrombin-induced brain injury may shed light on future interventions for hemorrhagic stroke.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research