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Drug: Folic Acid

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Total 203 results found since Jan 2013.

3 reasons your child shouldn’t go “gluten-free” (unless your doctor says so)
Follow me at @drClaire There is a puzzling and worrisome new phenomenon that I am seeing as a pediatrician: parents who are putting their children on gluten-free diets. It’s puzzling because in the vast majority of cases it isn’t necessary — and it’s worrisome because, although parents are doing it because they think it’s healthy, a gluten-free diet can be very unhealthy for children. Gluten is a protein found in wheat, rye, barley, and some other grains. It’s in bread and other baked goods, cereals, pastas — and in many other foods in small amounts. For people with celiac disease, even those small amounts ca...
Source: New Harvard Health Information - June 7, 2016 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Healthy Eating Parenting Source Type: news

PS042 Risk Factors Associated with Hyperhomocysteinemia Besides Folate in a Chinese Community-Based Population
Homocysteine (Hcy) has been demonstrated as a new risk factor for cardiovascular disease especially stroke. Folic acid supplementation is the most effective method to lower Hcy levels, however, not always useful for all patients with hyperhomocysteinemia.
Source: CVD Prevention and Control - May 31, 2016 Category: Global & Universal Authors: F. Fan, J. JIa, X. Xu, X. Qin, Y. Yang, J. Li, Y. Zhang, Y. Huo Tags: Poster Abstract Source Type: research

Effects of Folate on Chronic Kidney Disease Progression
This secondary analysis of China Stroke Primary Prevention Trial data compares the effects of folic acid and enalapril vs enalapril alone on progression of CKD.
Source: JAMA Internal Medicine - August 22, 2016 Category: Internal Medicine Source Type: research

Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia
Folic acid (FA) deficiency is not only associated with an increased risk of ischemic stroke, but also with increased oxidative DNA damage and brain injury after cerebral ischemia –reperfusion. However, the cellular and molecular mechanisms underlying FA deficiency-associated neuropathogenesis are not completely understood. In the present study, we tested the hypothesis that neuronal autophagy in focal cerebral ischemia rats may be involved in the mechanisms of FA deficienc y -induced injury to neuronal cells.
Source: The Journal of Nutritional Biochemistry - September 6, 2016 Category: Biochemistry Authors: Yaqian Zhao, Guowei Huang, Shuang Chen, Yun Gou, Zhiping Dong, Xumei Zhang Source Type: research

Efficacy of Folic Acid Therapy on the Progression of Chronic Kidney Disease The Renal Substudy of the China Stroke Primary Prevention Trial
In this substudy of eligible China Stroke Primary Prevention Trial (CSPPT), 15 104 participants with an estimated glomerular filtration rate (eGFR) 30 mL/min/1.73 m2 or greater, were randomized to receive a single tablet daily containing 10 mg enalapril and 0.8 mg folic acid (n = 7545) or 10 mg enalapril alone (n = 7559). Overall, 15 104 Chinese adults with a mean (range) age of 60 (45-75) years were recruited; median follow-up was 4.4 years. There were 164 and 132 primary events in the enalapril group and the enalapril-folic acid group, respectively. Compared with the enalapril group, the enalap...
Source: Nephrology Now - November 11, 2016 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Chronic Kidney Disease Clinical Nephrology Source Type: research

Elevated Homocysteine Concentrations Decrease the Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitors in Hypertensive Patients.
CONCLUSIONS: Elevated Hcy concentrations significantly decreased the antihypertensive effect of the short-term and long-term enalapril-based antihypertensive treatment in previously untreated hypertensive patients. PMID: 27834686 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - November 9, 2016 Category: Cardiology Authors: Qin X, Li Y, Sun N, Wang H, Zhang Y, Wang J, Li J, Xu X, Liang M, Nie J, Wang B, Cheng X, Li N, Sun Y, Zhao L, Wang X, Hou FF, Huo Y Tags: Arterioscler Thromb Vasc Biol Source Type: research

Folic acid supplementation and chronic kidney disease progression
In contrast to prior studies demonstrating no benefit or even increased harm from B vitamin supplementation in patients with chronic kidney disease, a large randomized trial from China recently demonstrated small but statistically significant reductions in the risk of first stroke and chronic kidney disease progression with the addition of folic acid to enalapril in adults with hypertension. Differences in the study population and study intervention may explain these discordant results.
Source: Kidney International - November 21, 2016 Category: Urology & Nephrology Authors: Christina M. Wyatt, J. David Spence Tags: Nephrology Digest Source Type: research

Fatal Folic Acid Toxicity in Humans.
Abstract Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingestion of a large dose of folic acid generally manifests as neurological complications, which are reversible. In this present case, a 23-year-old pregnant woman committed suicide by consuming folic acid tablets and succumbed to death within 36 h. Postmortem toxicological analysis detected folic acid in viscera. Death following acute consumption of folic aci...
Source: Journal of Forensic Sciences - March 5, 2017 Category: Forensic Medicine Authors: Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A Tags: J Forensic Sci Source Type: research

Fatal folic acid toxicity in humans - Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A.
Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingest...
Source: SafetyLit - March 11, 2017 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news

Homocysteine and non-cardiac vascular disease.
Abstract Elevated homocysteine (Hcy) levels are predictors of cardiovascular disease (CVD). Hyperhomocysteinemia has also been associated with total and CVD mortality. However, whether Hcy is just a marker or plays a causal role in CVD remains to be elucidated. In this narrative review, we discuss the associations between Hcy and non-cardiac vascular diseases, namely stroke, peripheral artery disease (PAD), carotid artery disease, chronic kidney disease (CKD), atherosclerotic renal artery stenosis (ARAS), abdominal aortic aneurysm (AAA) and erectile dysfunction (ED). The effects of several drugs on Hcy levels are ...
Source: Current Pharmaceutical Design - March 17, 2017 Category: Drugs & Pharmacology Authors: Katsiki N, Perez-Martinez P, Mikhailidis DP Tags: Curr Pharm Des Source Type: research

How to Boost Your Stem Cells
A California man named Kris Boesen was completely paralyzed after breaking his neck in a terrible car crash last March. But now he can brush his teeth and hug his family again… He's even started to regain sensation in his legs. And it's all because of a simple procedure he underwent about a month after his accident: stem cell therapy. During Kris' procedure, researchers at the University of Southern California injected 10 million stem cells into his spinal cord. Within two weeks, he could wiggle his fingers. Three months later, he was able to feed himself, write his name and operate his wheelchair. His re...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news

Markers of early vascular ageing.
CONCLUSIONS: Vascular measurements may better represent the continuum of cardiovascular disease from a young healthy to an aged diseased vessel that is going to produce adverse clinical events. PMID: 28356037 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - March 28, 2017 Category: Drugs & Pharmacology Authors: Kotsis V, Antza C, Doundoulakis I, Stabouli S Tags: Curr Pharm Des Source Type: research

Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT) Vitamins, minerals, and phytochemicals
Conclusions: Enalapril–folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - April 3, 2017 Category: Nutrition Authors: Qin, X., Li, Y., He, M., Tang, G., Yin, D., Liang, M., Wang, B., Nie, J., Huo, Y., Xu, X., Hou, F. F. Tags: Research Need: Role of Nutrition in Health Maintenance, Research Need: Role of Nutrition in Medical Management Vitamins, minerals, and phytochemicals Source Type: research

Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling.
CONCLUSION: Folic acid inhibits dedifferentiation of PDGF-BB-induced VSMCs by suppressing mTOR/P70S6K signaling. PMID: 28386356 [PubMed]
Source: American Journal of Translational Research - April 9, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Association of Serum Uric Acid with Increased Risk of Cancer among Hypertensive Chinese
This study included 20577 adult hypertensive patients with valid SUA measurements who participated in the China Stroke Primary Prevention Trial where subjects were randomly assigned to receive a double‐blind treatment of either 10mg enalapril (n=10286) or 10.8mg enalapril‐folic acid (n=10291). Subjects were prospectively followed for a median of 4.5 years. Cox proportional hazards models were used to calculate hazards ratios (HR) of cancer risk associated with SUA. A total of 232 participants developed cancer. SUA was independently associated with increased cancer risk in the enalapril group [HR: 1.12, (95% CI: 1.03‐...
Source: International Journal of Cancer - April 10, 2017 Category: Cancer & Oncology Authors: Juan Yang, Yupeng Wang, Qianqian Zhao, Xianglin Zhang, Xiaobin Wang, Xianhui Qin, Rong Zhang, Lin Shen, Xiaodong Jiang, Hua Jiang, Yu Lei, Binyan Wang, Jin Gu, Fan Fan Hou, Yong Huo, Wei Gao, Xiping Xu Tags: Research Article Source Type: research