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Drug: Methotrexate

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Total 7800 results found since Jan 2013.

Methotrexate for the Treatment of Pediatric Alopecia Areata.
This study present a case series reviewing the efficacy of methotrexate in our pediatric patients with alopecia areata, making use of a retrospective chart review design from 2011-2016. In this data set, 8/14 subjects (57%) experienced good regrowth with methotrexate, while 3/14 (21%) had a response that could not be assessed due to loss to follow-up or premature discontinuation of the medication. No cases discontinued the medication due to recognized methotrexate side effects. This review suggests methotrexate is a generally safe and often effective medication in pediatric alopecia areata. PMID: 28627278 [PubMed - as ...
Source: Journal of Dermatological Treatment - June 20, 2017 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Effect of ursodeoxycholic acid and vitamin E in the prevention of liver injury from methotrexate in pediatric leukemia.
CONCLUSION: Low-dose methotrexate does not cause significant liver fibrosis in pediatric leukemia. UDCA and vitamin E have minimal roles in hepatoprotection among pediatric patients with ALL. PMID: 29749328 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - March 1, 2018 Category: Gastroenterology Authors: Bordbar M, Shakibazad N, Fattahi M, Haghpanah S, Honar N Tags: Turk J Gastroenterol Source Type: research

Thiopurines are negatively associated with anthropometric parameters in pediatric Crohn's disease.
CONCLUSION: Our results suggest poor efficacy of thiopurines and a possible sex difference in statural growth response to infliximab in pediatric CD. Prospective longitudinal studies are required. PMID: 29760546 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 14, 2018 Category: Gastroenterology Authors: Gupta N, Lustig RH, Chao C, Vittinghoff E, Andrews H, Leu CS Tags: World J Gastroenterol Source Type: research

The Continental Divide: Anti-TNF Use in Pediatric IBD Is Different in North America Compared to Other Parts of the World.
Conclusions: Anti-TNF use in North America varies significantly from elsewhere. PMID: 30009157 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - July 18, 2018 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Disparities in Neurotoxicity Risk and Outcomes among Pediatric Acute Lymphoblastic Leukemia Patients.
Conclusion: Hispanic ethnicity was associated with increased risk of methotrexate neurotoxicity, which was associated with treatment modifications and relapse. Understanding the mechanism and predictors of methotrexate neurotoxicity is important to improving treatment outcomes in pediatric ALL. Clin Cancer Res; 1-6. ©2018 AACR. PMID: 30206159 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 11, 2018 Category: Cancer & Oncology Authors: Taylor OA, Brown AL, Brackett J, Dreyer ZE, Moore IK, Mitby P, Hooke MC, Hockenberry MJ, Lupo PJ, Scheurer ME Tags: Clin Cancer Res Source Type: research

Long term effectiveness of RA-1 as a monotherapy and in combination with disease modifying anti-rheumatic drugs in the treatment of rheumatoid arthritis
ConclusionRA-1 is safe and effective in the long term management of symptomatic active chronic RA. DMARDs and/or steroids can be used judiciously along with RA-1 to treat difficult disease/flares. Further studies are required to evaluate RA-1 in early RA. This paves way for research and application of integrative therapeutic approach in clinical medicine.
Source: Journal of Ayurveda and Integrative Medicine - September 21, 2018 Category: Complementary Medicine Source Type: research

Systemic Treatment of Moderate to Severe Psoriasis in Pediatric Patients in Galicia, Spain: A Descriptive Study.
CONCLUSIONS: Phototherapy, followed by methotrexate, was the most common treatment for moderate to severe psoriasis in this series of patients under 18 years. The treatments showed a favorable safety profile and were associated with a good response rate of 66% at week 12 (systemic treatment and phototherapy) and 36% at week 24 (systemic treatment only). PMID: 30293554 [PubMed - in process]
Source: Actas Dermo-Sifiliograficas - October 1, 2018 Category: Dermatology Authors: Batalla A, Fernández-Torres R, Rodríguez-Pazos L, Monteagudo B, Pardavila-Riveiro R, Rodríguez-Lojo R, Zulaica Á, Cabanillas M, Fonseca E, León Á, Fernández-Díaz L, Abalde T, Salgado-Boquete L, Valdés F, Seoane-Pose MJ, Vázquez-Veiga H, Suárez- Tags: Actas Dermosifiliogr Source Type: research

Efficacy of High-Dose Methotrexate in Pediatric Non-Infectious Uveitis.
CONCLUSION: In this retrospective study on pediatric auto-immune uveitis, high dose MTX was associated with a shorter time to remission on medication as compared to low dose MTX, while side effects were comparable in both groups. PMID: 30346845 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - October 24, 2018 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia.
Abstract ETV6-RUNX1-positive B precursor acute lymphoblastic leukemia (B-ALL) is a common subtype of pediatric B-ALL that has shown excellent outcomes in contemporary clinical trials for pediatric B-ALL. Examinations of the possibility of reducing therapeutic intensity may thus be explored. This prospective study examined outcomes in 205 pediatric patients with ETV6-RUNX1-positive B-ALL uniformly treated following the Japan Association of Childhood Leukemia Study Group (JACLS) ALL-02 protocol. The JACLS ALL-02 protocol does not employ minimal residual disease detected by polymerase chain reaction (PCR-MRD)-based r...
Source: International Journal of Hematology - January 28, 2019 Category: Hematology Authors: Usami I, Imamura T, Takahashi Y, Suenobu SI, Hasegawa D, Hashii Y, Deguchi T, Hori T, Shimada A, Kato K, Ito E, Moriya-Saito A, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Sato A, Horibe K, Japan Association of Childhood Leukemia Study Group (JACLS) Tags: Int J Hematol Source Type: research

Improved outcome of Pediatric-inspired protocol for high risk adolescent and young adult (AYA) acute lymphoblastic leukemia utilizing peg-asparaginase and escalating dose of methotrexate, tolerability and outcome
ConclusionThe use of pediatric-inspired protocol for high risk AYA ALL was effective and well tolerated with improvement in OS and DFS compared to historical data using adult protocols in such population
Source: Clinical Lymphoma Myeloma and Leukemia - May 17, 2019 Category: Cancer & Oncology Source Type: research

Improved Outcome of a Pediatric-Inspired Protocol for High-Risk Adolescent and Young Adult Acute Lymphoblastic Leukemia Patients Using Peg-Asparaginase and Escalating Dose of Methotrexate: Tolerability and Outcome
ConclusionThe use of a pediatric-inspired protocol for high-risk AYA ALL patients was effective and well tolerated with improvement in OS and DFS compared with historical data using adult protocols in such populations.
Source: Clinical Lymphoma Myeloma and Leukemia - August 2, 2019 Category: Cancer & Oncology Source Type: research

Risk of brainstem necrosis in pediatric patients with central nervous system malignancies after pencil beam scanning proton therapy.
Conclusion: The rate of symptomatic brainstem necrosis was extremely low after treatment with PBS-PT in this study. Further work to clarify clinical and dosimetric parameters associated with risk of brainstem necrosis after PBS-PT is needed. PMID: 31512931 [PubMed - as supplied by publisher]
Source: Acta Oncologica - September 11, 2019 Category: Cancer & Oncology Authors: Vogel J, Grewal A, O'Reilly S, Lustig R, Kurtz G, Minturn JE, Shah AC, Waanders AJ, Belasco JB, Cole KA, Fisher MJ, Phillips PC, Balamuth NJ, Storm PB, Hill-Kayser CE Tags: Acta Oncol Source Type: research

Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients
ConclusionsThis study represents one of the most comprehensive evaluations of HD-MTX PK across a wide range of ages and disease types. After accounting for differences in renal function, age did not impact CL, although toxicity patterns differed by age. The model allows for early identification of patients with slowed MTX clearance and at higher risk of toxicity.
Source: Cancer Chemotherapy and Pharmacology - October 3, 2019 Category: Cancer & Oncology Source Type: research

Genes, Vol. 11, Pages 468: Pharmacogenomic Markers of Methotrexate Response in the Consolidation Phase of Pediatric Acute Lymphoblastic Leukemia Treatment
ukic Sonja Pavlovic Methotrexate (MTX) is one of the staples of pediatric acute lymphoblastic leukemia (ALL) treatment. MTX targets the folate metabolic pathway (FMP). Abnormal function of the enzymes in FMP, due to genetic aberrations, leads to adverse drug reactions. The aim of this study was to investigate variants in pharmacogenes involved in FMP and their association with MTX pharmacokinetics (MTX elimination profile) and toxicity in the consolidation therapy phase of pediatric ALL patients. Eleven variants in the thymidylate synthetase (TYMS), methylenetetrahydrofolate reductase (MTHFR), dihydrofolate reductase...
Source: Genes - April 23, 2020 Category: Genetics & Stem Cells Authors: Nikola Kotur Jelena Lazic Bojan Ristivojevic Biljana Stankovic Vladimir Gasic Lidija Dokmanovic Nada Krstovski Goran Milosevic Dragana Janic Branka Zukic Sonja Pavlovic Tags: Article Source Type: research

Auditory attention late effects in pediatric acute lymphoblastic leukemia.
This study sought to characterize auditory attention functioning among pediatric Acute Lymphoblastic Leukemia (ALL) survivors treated on a chemotherapy-only protocol, given previous literature suggesting late impact on sustained visual attention. We hypothesized similar deficits would be observed in auditory attention relative to previous literature indicating weakness with aspect of visual attention in this population. Survivors (n = 107, 53 females, M = 12.80 years) completed the Conners Continuous Auditory Test of Attention (CATA). Parents completed the Behavior Assessment System for Children, Second Edition and rep...
Source: Child Neuropsychology - May 31, 2020 Category: Child Development Authors: Holland AA, Clem MA, Lampson E, Stavinoha PL Tags: Child Neuropsychol Source Type: research