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Medicine-Induced Acute Kidney Injury Findings from Spontaneous Reporting Systems, Sequence Symmetry Analysis and a Case –Control Study with a Focus on Medicines Used in Primary Care
ConclusionThis research highlights a number of medicines that may contribute to acute injury; however, we had an insufficient sample to confirm associations of some medicines. Spironolactone, furosemide, and trimethoprim with sulfamethoxazole are medicines that, in particular, need to be used carefully and monitored closely in patients in the community at risk of acute kidney injury.
Source: Drug Safety - September 21, 2022 Category: Drugs & Pharmacology Source Type: research

PREVENT-DM Comparative Effectiveness Trial of Lifestyle Intervention and Metformin
Conclusions In the first comparative effectiveness trial of diabetes prevention treatments, a 12-month ILI produced significantly greater weight loss than metformin and standard care among Latinas with prediabetes. These data suggest that ILI delivered by promotoras is an effective strategy for preventing diabetes in this high-risk group, which may be superior to metformin. Future pragmatic trials involving larger samples should examine differences in diabetes incidence associated with these treatments.
Source: American Journal of Preventive Medicine - May 17, 2017 Category: International Medicine & Public Health Source Type: research

The Healthy Longevity Global Grand Challenge at the National Academy of Medicine
The institutions of the world are slowly waking to the potential of treating aging as a medical condition, thereby postponing, reversing, and ultimately entirely preventing age-related disease. The side-effect will be greatly extended lives, lived in good health, in youthful vigor. Aging is the accumulation of cell and tissue damage, and rejuvenation is the periodic repair of this damage. The research and development communities are only just starting on the road of damage repair in medicine. The first rejuvenation therapies, in the form of senolytic treatments to selectively destroy senescent cells, are only now emerging....
Source: Fight Aging! - April 16, 2019 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

It is Entirely Reasonable to Consider That There Is No Limit to Human Life Span
The author of this commentary is entirely too enthusiastic about mTOR inhibitors as a tool to slow the aging process, but here he is largely focused on a different question. He argues (a) the sensible point that limits to aging and longevity are entirely determined by medical technology, and (b) the more debatable point that old people do not receive sufficient application of present forms of medical technology, and this is life-limiting. How much of the observed compression of morbidity of recent decades, meaning that people are living more healthy, functional years without an increase in overall life expectancy, is the r...
Source: Fight Aging! - December 14, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Pharmacological Management of Obesity in Pediatric Patients.
CONCLUSIONS: Lifestyle interventions remain the treatment of choice in pediatric obesity, but concomitant pharmacotherapy may be beneficial in some patients. Orlistat should be considered as second-line therapy for pediatric obesity. Evidence suggests that other diabetes and antiepileptic medications may also provide weight-loss benefits, but safety should be further evaluated. PMID: 25366340 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - November 3, 2014 Category: Drugs & Pharmacology Authors: Boland CL, Harris JB, Harris KB Tags: Ann Pharmacother Source Type: research

Treatment of Pediatric Type 2 Diabetes.
CONCLUSION: Metformin and insulin remain the mainstay of treatment for T2DM in pediatric patients. More robust studies are needed to assist in the provision of evidence-based guidance for the treatment of T2DM in youth. PMID: 27307414 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - June 14, 2016 Category: Drugs & Pharmacology Authors: Smith JD, Mills E, Carlisle SE Tags: Ann Pharmacother Source Type: research

Landmark Results Achieved in Aging and Chronic Disease: Danish Group Extends Disease-free Life by 8 Years
By WILLIAM H. BESTERMANN JR., MD New Scientific Breakthroughs Can Provide a Longer Healthier Life Twenty-one years of follow-up comparing usual care with a protocol-driven team-based intervention in diabetes proved that healthy life in humans can be prolonged by 8 years. These results were achieved at a lower per patient per year cost. Aging researchers have been confident that we will soon be able to prolong healthy life. This landmark study shows this ambitious goal can be achieved now with lifestyle intervention and a few highly effective proven medications. These medications interfere with the core molecular biol...
Source: The Health Care Blog - July 11, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients aging chronic disease Denmark Diabetes William Bestermann Source Type: blogs

Metformin inhibits cholesterol ‑induced adhesion molecule expression via activating the AMPK signaling pathway in vascular smooth muscle cells
Mol Med Rep. 2021 Oct;24(4):709. doi: 10.3892/mmr.2021.12348. Epub 2021 Aug 13.ABSTRACTRecruitment of lymphocytes to the vascular wall contributes to the pathogenesis of atherosclerosis (AS). The expression of cellular adhesion molecules, such as vascular cell adhesion molecule‑1 and intercellular adhesion molecule‑1, serves a critical role in mediating lymphocyte adhesion to the vascular wall. Cholesterol loading induces the expression of adhesion molecules in vascular smooth muscle cells (VSMCs), but the underlying mechanism is not completely understood. The present study aimed to investigate the mechanism underlying...
Source: Molecular Medicine - August 16, 2021 Category: Molecular Biology Authors: Qi Liu Mengyue Yang Lu Zhang Ruoxi Zhang Xingtao Huang Xuedong Wang Wenjuan Du Jingbo Hou Source Type: research

Designing novel therapies against sarcomas in the era of personalized medicine and economic crisis.
Abstract Drug "repurposing" is the process of finding new therapeutic indications for existing drugs, and can be considered as a more efficient and realistic strategy for the design of therapies against rare diseases than the current efforts to develop targeted-drugs. In this review, we explore the difficulties related to the identification and development of tailored therapies for individual patients with sarcomas, which are relatively rare diseases characterized by an extreme genetic and histologic variability. Overall, sarcomas comprise about 1% of all adult tumors and 10% of pediatric cancers. They are convent...
Source: Current Pharmaceutical Design - February 4, 2013 Category: Drugs & Pharmacology Authors: Manara MC, Garofalo C, Ferrari S, Belfiore A, Scotlandi K Tags: Curr Pharm Des Source Type: research

The availability of six tracer medicines in private medicine outlets in Uganda
Conclusions The regulatory process should be improved through the enforcement of outlet licensing and medicine registration. Additional studies to elucidate the reasons behind the use of private medicine outlets over the public sector would assist the government in implementing interventions to increase use of public sector medicine outlets.
Source: Journal of Pharmaceutical Policy and Practice - December 8, 2014 Category: Pharmaceuticals Source Type: research

An overview of diabetes management in schizophrenia patients: office based strategies for primary care practitioners and endocrinologists.
Authors: Annamalai A, Tek C Abstract Diabetes is common and seen in one in five patients with schizophrenia. It is more prevalent than in the general population and contributes to the increased morbidity and shortened lifespan seen in this population. However, screening and treatment for diabetes and other metabolic conditions remain poor for these patients. Multiple factors including genetic risk, neurobiologic mechanisms, psychotropic medications, and environmental factors contribute to the increased prevalence of diabetes. Primary care physicians should be aware of adverse effects of psychotropic medications tha...
Source: International Journal of Endocrinology - April 18, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Metformin as Adjunctive Therapy for Pediatric Patients With Hidradenitis Suppurativa.
DISCUSSION: For some pediatric patients, metformin as an adjunctive therapy may help improve control of HS with minimal side effects. Adequately designed and controlled studies are needed to further evaluate the role of metformin, and efficacy, tolerability and safety in the pediatric HS patients. J Drugs Dermatol. 2020;19(12): doi:10.36849/JDD.2020.5447. PMID: 33346525 [PubMed - in process]
Source: Journal of Drugs in Dermatology - December 23, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

The benefit of metformin in the treatment of pediatric non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials
Conclusion: According to the data of this meta-analysis, treatment with metformin failed to statistically improve liver enzymes but may be beneficial in the improvement of lipid parameters and insulin metabolism regulation in pediatric patients with NAFLD. As there are not enough available studies in the literature, the influence of metformin on liver ultrasonography or histology in pediatric NAFLD should be further analyzed in future studies.What is Known:• Lifestyle modification with weight loss through physical activity and dietary modification is the recommended treatment option for pediatric NAFLD.• Metformin may ...
Source: European Journal of Pediatrics - August 28, 2023 Category: Pediatrics Source Type: research

Family Physicians are Complex Care Physicians and Quality of Care Advancement Experts.
Abstract This issue's policy brief provides a good summary point for this issue: family physicians are complex care physicians (in addition to their other many roles). Another article demonstrates that family physicians provide more care during a preventive gynecologic visit than obstetrician-gynecologists. Completing the American Board of Family Medicine Maintenance of Certification modules are associated with higher quality of care. A learning collaborative shows the fruits of their effort to implement patient-centered medical homes. A new risk calculator for colorectal cancer is presented. Pregnant patients are...
Source: American Family Physician - January 1, 2014 Category: Primary Care Authors: Bowman MA, Neale AV Tags: J Am Board Fam Med Source Type: research