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A Kinematic Study of Progressive Micrographia in Parkinson's Disease
This study has investigated the kinematic features of progressive micrographia during a repetitive writing task. Twenty-four PD patients with duration since diagnosis of <10 years and 24 age-matched controls wrote the letter “e” repeatedly. PD patients were studied in defined off states, with scoring of motor function on the Unified Parkinson's Disease Rating Scale Part III. A digital tablet captured x-y coordinates and ink-pen pressure. Customized software recorded the data and offline analysis derived the kinematic features of pen-tip movement. The average size of the first and the last fi...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD)
RARITAN, N.J., May 23, 2022 – Findings from the XARELTO® (rivaroxaban) Phase 3 COMPASS Long-Term Open Label Extension (LTOLE) study and the XARELTO® in Combination with Acetylsalicylic Acid (XATOA) registry have been published in the European Society of Cardiology’s (ESC) European Heart Journal, Cardiovascular Pharmacotherapy. Additionally, the XATOA registry was presented at the American Congress of Cardiology’s 71st Annual Scientific Session (ACC.22). These studies provide further evidence supporting the role of dual pathway inhibition (DPI) with the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 100 mg...
Source: Johnson and Johnson - May 23, 2022 Category: Pharmaceuticals Source Type: news

Neurophysiological Analysis of Intermanual Transfer in Motor Learning
In this study, MEPs were induced during the subject’s imaged kinesthetic MI. This involves recalling muscle contraction based on a muscle sensory image and was reported to indicate the activity of brain regions similar to those involved in actual muscle contraction (Ruby and Decety, 2001). In the transfer training group, the muscle sensory image evaluation correlated to the actual task execution with the right hand. As a result, it was easy to recall the kinesthetic MI for the training task, thus affecting MI of the non-trained limbs so that MEP changes occurred in the left hand’s MI. In addition, brain exc...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research

Exploring Training Effect in 42 Human Subjects Using a Non-invasive Sensorimotor Rhythm Based Online BCI
Conclusion In this study, we analyzed a pooled dataset consisting of 42 subjects’ three BCI training sessions. The behavioral performance results showed that there was a significant increase of BCI PVC accuracy (p = 0.004) and a marginal significant improvement of ITR (p = 0.05) in the third training session compared to the first session. No other significant difference of behavioral measures such as group average abort rate or feedback duration was found across the training sessions. Further analysis on the group average R2 value indicated that there was a significant difference of the R2 value on the first traini...
Source: Frontiers in Human Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Learning to Walk Again
When someone suffers a stroke, he or she often loses some mobility, and some 60 percent of survivors are left with lower-limb deficits. “They usually have one leg that's more impaired than the other leg, and then they undergo rehabilitation and physical therapy. And often they don't fully recover,” said Conor Walsh, professor of engineering and applied sciences at the John A. Paulson Harvard School of Engineering and Applied Sciences and a core faculty member at the Wyss Institute for Biologically Inspired Engineering, in an interview with MD+DI. But a new device called ReSto...
Source: MDDI - April 17, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Design Source Type: news

Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Hands-Free Human-Computer Interface Based on Facial Myoelectric Pattern Recognition
Conclusion A facial movement-machine interface was developed in this study in order to help users with limited hand function manipulate electronic devices. Facial movements were detected using four EMG sensors, and five movement patterns were classified using myoelectric pattern recognition algorithms. The results from 10 able-bodied subjects show that facial movements can be detected and classified at high accuracies. The pattern-based continuous mapping between facial movements and cursor actions achieved high performance in both a typing task and a drawing task. Ethics Statement This study was approved by the Committ...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research

MRI for all: Cheap portable scanners aim to revolutionize medical imaging
.news-article__hero--featured .parallax__element{ object-position: 47% 50%; -o-object-position: 47% 50%; } The patient, a man in his 70s with a shock of silver hair, lies in the neuro intensive care unit (neuro ICU) at Yale New Haven Hospital. Looking at him, you’d never know that a few days earlier a tumor was removed from his pituitary gland. The operation didn’t leave a mark because, as is standard, surgeons reached the tumor through his nose. He chats cheerfully with a pair of research associates who have come to check his progress with a new and potentially revolutionary device they are testing. The cylind...
Source: Science of Aging Knowledge Environment - February 23, 2023 Category: Geriatrics Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Millennials Struggling to Care for Aging Baby Boomer Parents Call for Better Paid Leave
When Oniqa Moonsammy, 33, brought her uncle home from the hospital in early February following his stroke late last year, she planned to help her mother care for the 62-year-old as he regained his strength, figured out how to brush his own teeth again and managed his medications. But when they opened the door to the Brooklyn, N.Y., home her uncle shared with his father, Moonsammy saw her grandfather slumped in a chair. He, too, was having a severe stroke. Moonsammy used to work five days a week as a hostess at a restaurant in Brooklyn and often spent time with her boyfriend or went to bars with friends. Now her life revolv...
Source: TIME: Health - March 19, 2018 Category: Consumer Health News Authors: Abigail Abrams Tags: Uncategorized Aging caregivers caregiving family leave FMLA paid family leave Source Type: news

Medical Nutrition Education, Training, and Competencies to Advance Guideline-Based Diet Counseling by Physicians: A Science Advisory From the American Heart Association.
lar and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Stroke Council Abstract Growing scientific evidence of the benefits of heart-healthy dietary patterns and of the massive public health and economic burdens attributed to obesity and poor diet quality have triggered national calls to increase diet counseling in outpatients with atherosclerotic cardiovascular disease or risk factors. However, despite evidence that physicians are willing to undertake this task and are viewed as credible sources of diet information, they engage patients in diet counseling at less than desirable rates and...
Source: Circulation - April 30, 2018 Category: Cardiology Authors: Aspry KE, Van Horn L, Carson JAS, Wylie-Rosett J, Kushner RF, Lichtenstein AH, Devries S, Freeman AM, Crawford A, Kris-Etherton P, American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovasc Tags: Circulation Source Type: research

Unhealthy Behaviors, Prevention Measures, and Neighborhood Cardiovascular Health: A Machine Learning Approach
This study identifies and ranks predictors of cardiovascular health at the neighborhood level in the United States. We merged the 500 Cities Data and the 2011-2015 American Community Survey to create a new data set that includes sociodemographic characteristics, health behaviors, prevention measures, and cardiovascular health outcomes for more than 28 000 census tracts in the United States. We used random forest to rank predictors of coronary heart disease and stroke. For coronary heart disease, the top 5 ordered predictors were the prevalence of taking medicine for high blood pressure control, binge drinking, being aged 6...
Source: Journal of Public Health Management and Practice - December 5, 2018 Category: Health Management Tags: Research Reports: Research Brief Report Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Morphological and Whole-Word Semantic Processing Are Distinct: Event Related Potentials Evidence From Spoken Word Recognition in Chinese
In conclusion, the present study provides electrophysiological evidence of the dissociation of morphological and whole-word semantic processing in Chinese spoken word processing. The results identified a central-anterior morphological N400 effect when morphemic meaning conflicts with whole-word semantics, in addition to a classic semantic N400 effect with significantly reduced amplitude in central-parietal areas. Our results also showed that the morphological N400 effect is negatively correlated with reading ability. These results demonstrate the important role of morphological processing in Chinese spoken word recognition...
Source: Frontiers in Human Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

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