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Cardiac Imaging Within Emergency CT Angiography for Acute Stroke Can Detect Atrial Clots
This study was approved by the ethics committee of the medical faculty of the Ruhr University Bochum. FIGURE 1 Figure 1. Flow chart showing the selection of the study population. Results A total of 59 patients underwent emergency CCTA (Figure 2A) for suspected stroke, of which 44 received the final diagnosis ischemic stroke. There were 17 patients who had ischemic stroke or TIA and known or newly diagnosed atrial fibrillation (Table 1; mean age: 77.5 years, standard deviation: 8.4 years; 53% female). As hypothesized, intracardiac thrombi could be visualized: once in an artificially occluded left atrial appe...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Researcher Studies Statins for Stroke Therapy
Stacy Pigott A $2.8 million grant may help develop an improved therapeutic treatment for acute ischemic stroke patients to let them recover faster with fewer long-term complications. The protocol hinges on effectively delivering statins to the brain, where their neuroprotective properties can help save tissue damaged by stroke. Aug. 7, 2020 University of Arizona Health Sciencesnhg-PATRICK-RONALDSON_DSC6492-web.jpg Patrick Ronaldson (right), associate professor in the College of Medicine – Tucson's Department of Pharmacology, and doctoral students Erica Williams and Robert Betterton discuss their latest researc...
Source: The University of Arizona: Health - August 6, 2020 Category: Universities & Medical Training Authors: mittank Source Type: research

Pregnancy-Associated Stroke and Outcomes Related to Timing and Hypertensive Disorders
CONCLUSION: A nationally representative sample of hospitalizations in the United States indicates an increasing trend in the rate of postpartum stroke. Almost half of hospitalizations with pregnancy-associated stroke have concomitant hypertensive disorders. Risk of adverse outcomes, but not mortality, is elevated in patients with stroke occurring in the postpartum period and stroke associated with hypertensive disorders.PMID:37411017 | DOI:10.1097/AOG.0000000000005249
Source: Obstetrics and Gynecology - July 6, 2023 Category: OBGYN Authors: Ghamar Bitar Baha M Sibai Han-Yang Chen Natalie Neff Sean Blackwell Suneet P Chauhan Michal Fishel Bartal Source Type: research

UCLA Health launches pioneering mobile stroke unit with support from L.A. County
Roughly every 40 seconds, someone in the United States will have a stroke. Almost every four minutes, one of those people will die as a result. Against that backdrop, UCLA Health has officially launched the first mobile stroke unit on the West Coast, enabling rapid delivery of brain-saving medications to stroke patients who might otherwise face debilitating delays in treatment.  As part of the first phase of a pilot program, the specialized ambulance unit and highly trained personnel began responding in September to select 911 calls in Santa Monica in coordination with the Santa Monica Fire Department. With support from t...
Source: UCLA Newsroom: Health Sciences - October 26, 2017 Category: Universities & Medical Training Source Type: news

Accuracy of Prehospital Identification of Stroke in a Large Stroke Belt Municipality.
CONCLUSIONS: EMD and EMS personnel in a large city in the Southeastern United States, with high stroke prevalence, had a relatively high sensitivity in identifying acute stroke patients. Paramedic accuracy was augmented by positive CPSS screening and by EMD recognition of stroke. PMID: 29596006 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - March 31, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Comparative mortality according to peripheral artery disease and coronary heart disease/stroke in the United States
CONCLUSIONS: In the US adults, PAD contributed to increased mortality in persons with and without CHD/stroke. The prognosis of PAD without CHD/stroke was no better than that of CHD/stroke without PAD. These results suggest the importance of recognizing the presence of PAD in the community.PMID:35584971 | DOI:10.1016/j.atherosclerosis.2022.04.029
Source: Atherosclerosis - May 18, 2022 Category: Cardiology Authors: Kunihiro Matsushita Yumin Gao Yingying Sang Shoshana H Ballew Maya Salameh Matthew Allison Elizabeth Selvin Josef Coresh Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Development, Validation of LC-MS/MS Method and Determination of Pharmacokinetic Parameters of the Stroke Neuroprotectant Neurounina-1 in Beagle Dog Plasma After Intravenous Administration
Conclusion The developed and validated method to quantify neurounina-1 in beagle dog plasma using LC-MS/MS presented sensitivity and selectivity, thus allowing the rapid and precise determination of the pharmacokinetics of this neuroprotective compound working in the low nanomolar range. Ethics Statement This study was carried out in accordance with the recommendations of the general ethical guidelines established by the Brazilian Society for Laboratory Animal Science (SBCAL). The protocol was approved by the Committee for Ethics in Animal Use – State University of Campinas (CEUA/UNICAMP, protocol n° 3340-...
Source: Frontiers in Pharmacology - April 24, 2019 Category: Drugs & Pharmacology Source Type: research

Short-term exposure to air pollution and incidence of stroke in the Women's Health Initiative.
CONCLUSIONS: In this large cohort of post-menopausal US women, daily NO2 and NOx were associated with higher risk of hemorrhagic stroke, but ambient levels of four other air pollutants were not associated with higher risk of total stroke, ischemic stroke, or ischemic stroke subtypes. PMID: 31382185 [PubMed - as supplied by publisher]
Source: Environment International - August 1, 2019 Category: Environmental Health Authors: Sun S, Stewart JD, Eliot MN, Yanosky JD, Liao D, Tinker LF, Eaton CB, Whitsel EA, Wellenius GA Tags: Environ Int Source Type: research

National Trends, Risk Factors, and Outcomes of Acute In-hospital Stroke After Lung Transplantation in the United States: Analysis of the United Network for Organ Sharing Registry
Chest. 2023 Apr 11:S0012-3692(23)00503-2. doi: 10.1016/j.chest.2023.04.007. Online ahead of print.ABSTRACTBACKGROUND: Lung transplantation is the definitive treatment for end-stage lung failure. However, there have been no large, long-term studies on the impact of acute in-hospital stroke in this population.RESEARCH QUESTION: What are the trends, risk factors, and outcomes of acute stroke in patients undergoing lung transplantation in the United States?STUDY DESIGN AND METHODS: We identified adult first-time, isolated lung transplant (LTx) recipients from the United Network for Organ Sharing (UNOS) database, which comprehe...
Source: Chest - April 13, 2023 Category: Respiratory Medicine Authors: Benjamin L Shou Christopher Wilcox Isabella Florissi Aravind Krishnan Bo Soo Kim Steven P Keller Glenn J R Whitman Ken Uchino Errol L Bush Sung-Min Cho Source Type: research

Stroke Mortality Among Black and White Adults Aged ≥35 Years Before and During the COVID-19 Pandemic - United States, 2015-2021
MMWR Morb Mortal Wkly Rep. 2023 Apr 21;72(16):431-436. doi: 10.15585/mmwr.mm7216a4.ABSTRACTStroke is the fifth leading cause of death and a leading cause of long-term disability in the United States (1). Although stroke death rates have declined since the 1950s, age-adjusted rates remained higher among non-Hispanic Black or African American (Black) adults than among non-Hispanic White (White) adults (1,2). Despite intervention efforts to reduce racial disparities in stroke prevention and treatment through reducing stroke risk factors, increasing awareness of stroke symptoms, and improving access to treatment and care for s...
Source: MMWR Morb Mortal Wkl... - April 21, 2023 Category: Epidemiology Authors: Quanhe Yang Xin Tong Linda Schieb F átima Coronado Robert Merritt Source Type: research