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Serum magnesium but not calcium was associated with hemorrhagic transformation in stroke overall and stroke subtypes: a case-control study in China
AbstractAssociation between serum calcium and magnesium versus hemorrhagic transformation (HT) remains to be identified. A total of 1212 non-thrombolysis patients with serum calcium and magnesium collected within 24  h from stroke onset were enrolled. Backward stepwise multivariate logistic regression analysis was conducted to investigate association between calcium and magnesium versus HT. Calcium and magnesium were entered into logistic regression analysis in two models, separately: model 1, as continuous va riable (per 1-mmol/L increase), and model 2, as four-categorized variable (being collapsed into quartiles). HT oc...
Source: Neurological Sciences - July 19, 2018 Category: Neurology Source Type: research

Differential associations of particle size ranges and constituents with stroke emergency-room visits in Shanghai, China
CONCLUSION: Ultra-fine particles and some PM2.5 constituents (i.e., carbonaceous fractions, inorganic ions and some elements) may be mainly responsible for the excess risk of stroke induced by PM2.5.PMID:35104777 | DOI:10.1016/j.ecoenv.2022.113237
Source: Ecotoxicology and Environmental Safety - February 1, 2022 Category: Environmental Health Authors: Yuhao Zhang Qinglin He Yaping Zhang Xiaowei Xue Haidong Kan Xin Wang Source Type: research

Predictive role of modifiable factors in stroke: an umbrella review
Discussion Diet with rich macronutrients and micronutrients, healthy dietary patterns and favourable physical, emotional health and environmental management should be promoted to decrease the burden of stroke. PROSPERO registration number CRD42021249921.
Source: BMJ Open - June 16, 2022 Category: General Medicine Authors: Wang, X., Liang, M., Zeng, F., Wang, Y., Yang, Y., Nie, F., Shang, M., Ta, N., Wen, L., Ou, L., Yang, Z., Liu, W. Tags: Open access, Neurology Source Type: research

Low Serum Magnesium Levels Are Associated With Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke
Conclusions: Lower serum magnesium levels in patients with ischemic stroke are associated with an increased risk of HT after intravenous thrombolysis, but perhaps only when serum magnesium is below a certain minimal concentration.
Source: Frontiers in Neurology - September 1, 2020 Category: Neurology Source Type: research

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Conclusion Collectively, pharmacokinetic and pharmacodynamic association studies provide evidence that the gut microbiota plays a vital role in the fate of crocin and crocetin in the gastrointestinal tract. In addition, the cross-interaction between gut microbiota and crocin might mediate the activation of the cerebral-protective effect of orally administered crocin. Ethics Statement This study was carried out in accordance with the recommendations of ‘Institutional Animal Research Committee guidelines, Animal Ethics Committee of China Pharmaceutical University.’ The protocol was approved by the ‘An...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you… Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China. I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1 We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004. Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news

Urinary element profiles and associations with cardiometabolic diseases: A cross-sectional study across ten areas in China
CONCLUSION: In China, the urinary levels of several toxic metals were significantly associated with the consumption of specific food groups and the risk of cardiometabolic diseases including diabetes and stroke.PMID:34896320 | DOI:10.1016/j.envres.2021.112535
Source: Environmental Research - December 13, 2021 Category: Environmental Health Authors: Lijiao Xu Yunan Liu Qianyu Zhao Huaidong Du Ying Gao Meijuan Bai Jun Lv Yu Guo Liming Li Liang Sun Xu Lin Zhengming Chen Yan Chen Geng Zong Source Type: research

Comparison of sodium, potassium, calcium, magnesium, zinc, copper and iron concentrations of elements in 24-h urine and spot urine in hypertensive patients with healthy renal function
Conclusions Spot urine can replace 24-h urine for estimating some of the elements in hypertensive patients with normal renal function.
Source: Journal of Trace Elements in Medicine and Biology - June 27, 2017 Category: Biochemistry Source Type: research

Plasma magnesium and the risk of new-onset hyperuricemia in hypertensive patients.
Abstract We aimed to evaluate the relationship of plasma magnesium with the risk of new-onset hyperuricemia, and examine any possible effect modifiers in hypertensive patients. This is a post-hoc analysis of the Uric acid (UA) Sub-study of the China Stroke Primary Prevention Trial (CSPPT). A total of 1685 participants were included in the current study. The main outcome was new-onset hyperuricemia defined as a UA concentration ≥417 μmol/L in men or ≥357 μmol/L in women. The secondary outcome was a change in UA concentration defined as UA at the exit visit minus that at baseline. During a median follow-up dur...
Source: The British Journal of Nutrition - March 25, 2020 Category: Nutrition Authors: Cao J, Zhang J, Zhang Y, Li H, Jiang C, Lin T, Zhou Z, Song Y, Liu C, Liu L, Wang B, Li J, Zhang Y, Cui Y, Huo Y, Wang X, Zhang H, Qin X, Xu X Tags: Br J Nutr Source Type: research

Plasma Magnesium Concentrations and Risk of Incident Cancer in Adults with Hypertension: A Nested Case-Control Study
Conclusions: Both low and high plasma magnesium concentrations were significantly associated with an increased incident risk of cancer, compared with the reference concentrations of 0.83 to #x3c;0.89 mmol/L among hypertensive adults.Ann Nutr Metab
Source: Annals of Nutrition and Metabolism - December 3, 2020 Category: Nutrition Source Type: research

Nomogram Including Serum Ion Concentrations to Screen for New-Onset Hypertension in Rural Chinese Populations Over a Short-Term Follow-up
CONCLUSIONS: The newly developed nomogram has good predictive ability and may effectively assess hypertension risk in high-risk rural areas in China.PMID:35569931 | DOI:10.1253/circj.CJ-22-0016
Source: Circulation Journal - May 15, 2022 Category: Cardiology Authors: Xueyao Zhang Guangxiao Li Yingxian Sun Source Type: research

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