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Total 1933 results found since Jan 2013.

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
In this report, we present a case of an adolescent male with all four cardinal symptoms of narcolepsy who was misdiagnosed with epilepsy, psychosis, and depression. We also discuss various issues regarding narcolepsy in children and adolescents. Case Report Mr. A, an 18-year-old man, presented to psychiatry outpatient services with excessive daytime sleepiness of approximately 1.5 years’ duration. When the chronology of symptoms was evaluated, it was evident that about 1.5 years before presentation, the patient had an episode of high-grade fever (101–103?F) and was empirically treated for typhoid and malaria. Within a ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

What Are Some Indications for Using Dexamethasone?
Discussion Corticosteroids are a group of drugs which can be naturally or synthetically produced. Naturally occurring substances are produced in the adrenal gland, and are protein-bound (primarily corticosteroid-binding globulin and albumin). In the target tissues, they may need to be converted to an active substance. They are then reduced, oxidized, hydroxylated or conjugated as measures to inactivate them. Synthetic steroids have less protein binding and depending on their structure are more or less resistant to inactivation. Prednisone is the glucocorticoid most often used for treatment, especially as it has a short hal...
Source: PediatricEducation.org - June 7, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.
Abstract Topological and stereo-electron characteristics are essential in major histocompability class II-peptide-T-cell receptor (MHC-p-TCR) complex formation for inducing an appropriate immune response. Modified high activity binding peptides (mHABPs) were synthesised for complete full protection antimalarial vaccine development producing a large panel of individually fully protection-inducing protein structures (FPIPS) and very high long-lasting antibody-inducing (VHLLAI) mHABPs. Most of those which did not interfere, compete, inhibit or suppress their individual VHLLAI or FPIPS activity contained or displayed ...
Source: Vaccine - February 27, 2014 Category: Allergy & Immunology Authors: Bermúdez A, Calderon D, Moreno-Vranich A, Almonacid H, Patarroyo MA, Poloche A, Patarroyo ME Tags: Vaccine Source Type: research

Pyrimidine Metabolism in Schistosomes: A comparison with Other Parasites and the Search for Potential Chemotherapeutic Targets
Publication date: Available online 21 July 2017 Source:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology Author(s): Mahmoud H. el Kouni Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and chronic parasitic ailment that affects more than 240 million people in 70 countries worldwide. It is the second most devastating parasitic disease after malaria. At least 200,000 deaths per year are associated with the disease. In the absence of the availability of vaccines, chemotherapy is the main stay for combating schistosomiasis. The antischistosomal arsenal is curren...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - July 21, 2017 Category: Molecular Biology Source Type: research

Preventing infections in children and adults with asplenia.
Authors: Lee GM Abstract An estimated 1 million people in the United States have functional or anatomic asplenia or hyposplenia. Infectious complications due to encapsulated organisms such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae can lead to fulminant sepsis and death, particularly in young children, in the period shortly after splenectomy, and in immunocompromised patients. Patients with asplenia are also at risk for less common infections due to Capnocytophaga, Babesia, and malaria. Antibiotic prophylaxis, vaccines, and patient and family education are the mainstays of preve...
Source: Hematology ASH Education Program - December 5, 2020 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Rwanda: Rwanda Optimistic About Latest Breakthrough in Search for a Malaria Vaccine
[New Times] Officials at Rwanda Biomedical Centre (RBC) have said they are optimistic about the recent unprecedented developments in the search for a malaria vaccine, and hope soon there will be a vaccine to complement the existing measures to fight the disease.
Source: AllAfrica News: Malaria - April 26, 2021 Category: Infectious Diseases Source Type: news

HBV Infection Is an Intermediate-Risk Disease, Whereas Anaemia Is a Mild-to-Moderate Public Health Problem in Young Ghanaian Adults: A Four-Year Retrospective Analysis of Students' Medical Records
CONCLUSION: Intentional preventative public health campaigns regarding anaemia, HBV, and HCV infection should, respectively, target females and young adult males to increase chances of making real change in behavioural attitudes in these at-risk groups.PMID:37475793 | PMC:PMC10356218 | DOI:10.1155/2023/9318984
Source: Biomed Res - July 21, 2023 Category: Research Authors: Samuel Amoah Andrew Nicholas Yartey Praise Fosu Adjei Margaret Owusu-Akyaw Joseph Boachie David Larbi Simpong Patrick Adu Source Type: research

What the Gates Foundation Has Achieved, 15 Years On
There are a whole lot of things you may or may not get to do in the next 15 years, but a few of them you can take for granted: eating, for one. Having access to a bank, for another. And then there’s the simple business of not dying of a preventable or treatable disease. Good for you—and good for most of us in the developed world. But the developed world isn’t the whole story. The bad—and familiar—news is that developing nations lag far behind in income, public health, food production, education and more. The much, much better news is that all of that is changing—and fast. The just-releas...
Source: TIME.com: Top Science and Health Stories - January 22, 2015 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized Africa child mortality cholera climate crops Disease Economics Education Food Gates Foundation global health Malaria measles mobile banking polio seeds Source Type: news

Medical Advice for Travelers.
CONCLUSION: The health risks associated with travel can be minimized by specialist medical advice. Many recommendations are empirical in nature and require further research. PMID: 33597073 [PubMed - as supplied by publisher]
Source: Deutsches Arzteblatt International - February 20, 2021 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Blood Trials: Transfusions, Injections, and Experiments in Africa, 1890-1920.
Abstract From about 1880 to 1920, a culture of medical experimentation promoted blood transfusion as a therapy for severe anemia in Europe, which was applied in German East Africa in 1892 for a case of blackwater fever, a complication of malaria afflicting mainly Europeans. This first case of blood transfusion in Africa, in which an African's blood was transfused into a German official, complicates the dominant narrative that blood transfusions in Africa came only after World War I. Medical researchers moreover experimented with blood serum therapies on human and animal subjects in Europe and Africa, injecting blo...
Source: Medical History - October 29, 2015 Category: History of Medicine Authors: Sunseri T Tags: J Hist Med Allied Sci Source Type: research

Health care, needs and barriers in seeking medical care for global health and sexual and reproductive health, among students from F élix Houphouët-Boigny University, Abidjan, Côte d'Ivoire.
CONCLUSION: Establishing a medical examination would improve health center visibility. The following services could be offered: (i) HIV, chlamydia and gonorrhea screening, (ii) hepatitis B virus screening and vaccination, (iii) provision and information about contraceptive methods, (iv) presentation of the university health center services. Dedicated spaces where students could have access to information about health-related topics (e.g. sexuality, nutrition, depression) could complete the university's healthcare offer. PMID: 28935430 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - September 24, 2017 Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research

Health of Special Immigrant Visa holders from Iraq and Afghanistan after arrival into the United States using Domestic Medical Examination data, 2014 –2016: A cross-sectional analysis
ConclusionIn this analysis, we observed that 14% of SIV adults had LTBI, 27% of SIVH had at least one intestinal parasite, and about half of SIV children had EBLL. Most adults were susceptible to HBV. In general, prevalence of infection was higher for most conditions among Afghan SIVH compared to Iraqi SIVH. The Centers for Disease Control and Prevention (CDC)Guidelines for the US Domestic Medical Examination for Newly Arriving Refugees can assist state public health departments and clinicians in the care of SIVH during the domestic medical examination. Future analyses can explore other aspects of health among resettled SI...
Source: PLoS Medicine - March 30, 2020 Category: Internal Medicine Authors: Gayathri S. Kumar Source Type: research

A brief history of selected malaria vaccine and medical interventions pursued by the Swiss Tropical and Public Health Institute and partners, 1943-2021
This article does not present new scientific data but takes a historical perspective. Its aim is to highlight the above-mentioned transformation by focusing on selected malaria research-cum-action interventions during the crucial period of the 1990s, which were tailored to the social-ecological settings where the disease was endemic. In order for this transformation to be successful, we intend to emphasise the importance of (i) having a fundamental understanding of local transmission; (ii) building and nurturing relationships with partner institutions; and (iii) developing a coherent research portfolio as key elements for ...
Source: Acta Tropica - August 31, 2021 Category: Infectious Diseases Authors: Lukas Meier Giovanni Casagrande Salim Abdulla Honorati Masanja Source Type: research