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Vaccination: Malaria Vaccine

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Total 1933 results found since Jan 2013.

Causes of hospital admission among people living with HIV worldwide: a systematic review and meta-analysis
Publication date: Available online 11 August 2015 Source:The Lancet HIV Author(s): Nathan Ford, Zara Shubber, Graeme Meintjes, Beatriz Grinsztejn, Serge Eholie, Edward J Mills, Mary-Ann Davies, Marco Vitoria, Martina Penazzato, Sabin Nsanzimana, Lisa Frigati, Daniel O'Brien, Tom Ellman, Olawale Ajose, Alexandra Calmy, Meg Doherty Background Morbidity associated with HIV infection is poorly characterised, so we aimed to investigate the contribution of different comorbidities to hospital admission and in-hospital mortality in adults and children living with HIV worldwide. Methods Using a broad search strat...
Source: The Lancet HIV - August 12, 2015 Category: Infectious Diseases Source Type: research

Development of new vaccines.
Abstract Recent and important advances in the fields of immunology, genomics, functional genomics, immunogenetics, immunogenomics, bioinformatics, microbiology, genetic engineering, systems biology, synthetic biochemistry, proteomics, metabolomics and nanotechnology, among others, have led to new approaches in the development of vaccines. The better identification of ideal epitopes, the strengthening of the immune response due to new adjuvants, and the search of new routes of vaccine administration, are good examples of advances that are already a reality and that will favour the development of more vaccines, thei...
Source: Genomics Proteomics ... - September 1, 2015 Category: Genetics & Stem Cells Authors: González-Romo F, Picazo JJ Tags: Enferm Infecc Microbiol Clin Source Type: research

In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage.
Abstract Genetically attenuated parasites (GAPs) that lack genes essential for the liver stage of the malaria parasite, and therefore cause developmental arrest, have been developed as live vaccines in rodent malaria models and recently been tested in humans. The genes targeted for elimination were often identified by trial and error. Here we present a systematic gene-protein and transcript-expression analyses of several Plasmodium species with the aim to identify candidate genes for the generation of novel GAPs. With a lack of liver stage expression data for human malaria parasites, we used data available for liv...
Source: Infection, Genetics and Evolution - September 5, 2015 Category: Genetics & Stem Cells Authors: Kumar H, Frischknecht F, Mair GR, Gomes J Tags: Infect Genet Evol Source Type: research

Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus.
Abstract The review covers the functional and structural approach followed by our group for more than 34 years in the search for a methodology that allows the rational design of chemically synthesized vaccines. An analogy between Odysseus, the cunning hero of the epic poem Odyssey by Homer, and the elusive Plasmodium parasite has been made, to review our research group's main considerations when developing a rational methodology for designing second generation, modified peptide-based, minimal subunit, multi-antigen, multi-stage, chemically synthesised vaccines against Plasmodium falciparum malaria. PMID: 2646...
Source: Vaccine - October 12, 2015 Category: Allergy & Immunology Authors: Patarroyo ME, Patarroyo MA, Pabón L, Curtidor H, Poloche LA Tags: Vaccine Source Type: research

A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions
Conclusions/Significance We produced a new library of recombinant full-length P. vivax ectodomains, established that the majority of them contain tertiary structure, and used them to identify predicted and novel protein-protein interactions. As well as identifying new interactions for further biological studies, this library will be useful in identifying P. vivax proteins with vaccine potential, and studying P. vivax malaria pathogenesis and immunity. Trial Registration ClinicalTrials.gov NCT00663546
Source: PLoS Neglected Tropical Diseases - December 23, 2015 Category: Tropical Medicine Authors: Jessica B. Hostetler et al. Source Type: research

A systematic review and meta-analysis on the safety of newly adjuvanted vaccines among children.
CONCLUSIONS: Our meta-analysis did not show any safety concerns in clinical trials of the newly adjuvanted vaccines in children ≤10 years of age. An unexplained increase of meningitis in one Phase III AS01-adjuvanted malaria trial and the link between narcolepsy and the AS03-adjuvanted pandemic vaccine illustrate that continued safety monitoring is warranted. PMID: 26740250 [PubMed - as supplied by publisher]
Source: Vaccine - December 28, 2015 Category: Allergy & Immunology Authors: Stassijns J, Bollaerts K, Baay M, Verstraeten T Tags: Vaccine Source Type: research

Tanzania: Search for Malaria Vaccine Gets Boost
[Citizen] Melbourne -Researchers at Melbourne's Walter and Eliza Hall Institute have discovered why the body's immune system is unable to develop immunity during a malaria infection.
Source: AllAfrica News: Malaria - January 13, 2016 Category: Infectious Diseases Source Type: news

Chemical and Plant-Based Insect Repellents: Efficacy, Safety, and Toxicity
Publication date: Available online 27 January 2016 Source:Wilderness & Environmental Medicine Author(s): James H. Diaz Most emerging infectious diseases today are arthropod-borne and cannot be prevented by vaccinations. Because insect repellents offer important topical barriers of personal protection from arthropod-borne infectious diseases, the main objectives of this article were to describe the growing threats to public health from emerging arthropod-borne infectious diseases, to define the differences between insect repellents and insecticides, and to compare the efficacies and toxicities of chemical and pla...
Source: Wilderness and Environmental Medicine - January 30, 2016 Category: Environmental Health Source Type: research

Anti-infectious human vaccination in historical perspective.
Authors: D'Amelio E, Salemi S, D'Amelio R Abstract A brief history of vaccination is presented since the Jenner's observation, through the first golden age of vaccinology (from Pasteur's era to 1938), the second golden age (from 1940 to 1970), until the current period. In the first golden age, live, such as Bacille Calmette Guérin (BCG), and yellow fever, inactivated, such as typhoid, cholera, plague, and influenza, and subunit vaccines, such as tetanus and diphtheria toxoids, have been developed. In the second golden age, the cell culture technology enabled polio, measles, mumps, and rubella vaccines be developed...
Source: International Reviews of Immunology - February 17, 2016 Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research

7 Expert-Backed Tips For Staying Healthy On Your Next Big Trip
As spring approaches, you may be thinking about this year’s summer getaway. Or maybe you’re an Type A planner who is already booking a Thanksgiving or Christmas trip. Whatever your travel style, here's something you probably haven't considered: How to stay healthy while abroad. While you probably won’t make a Pinterest board of vaccinations with the same enthusiasm as you pin must-eat pastries and stylish travel outfits, taking care of your health on a trip might just save your life. Here are seven tips to help keep your vacations as stress- and sickness-free as possible:  1. First, call your doctor....
Source: Healthy Living - The Huffington Post - March 23, 2016 Category: Consumer Health News Source Type: news

An evolutionary approach to identify potentially protective B cell epitopes involved in naturally acquired immunity to malaria and the role of EBA-175 in protection amongst denizens of Bolifamba, Cameroon
The search for a vaccine against malaria caused by Plasmodium falciparum has lasted for more than 100 years, with considerable progress in the identification of a number of vaccine candidates. The post-genomic er...
Source: Malaria Journal - May 20, 2016 Category: Infectious Diseases Authors: Raymond B. Nyasa, Helen K. Kimbi, Denis Zofou, Jeremy D. DeBarry, Jessica C. Kissinger and Vincent P. K. Titanji Source Type: research

Genome Editing by CRISPR/Cas9: a Game Change in the Genetic Manipulation of Protists
This article is protected by copyright. All rights reserved
Source: The Journal of Eukaryotic Microbiology - April 30, 2016 Category: Microbiology Authors: Noelia Lander, Miguel A. Chiurillo, Roberto Docampo Tags: Symposium Article Source Type: research

Lack of plasmodium surface-protein blocks mosquito infection
A previously unknown feature of the malaria parasite development has just been released by an international research team. Their study has shown that, contrary to what has been assumed so far, a Plasmodium surface-protein plays an essential role at a stage of its life cycle that occurs not in the body of the host, but in the guts of the Anopheles mosquito. The finding has consequences for the search for vaccines or drugs that could alleviate the suffering caused by malaria. By 2015, 214 million people were affected by the parasite, especially in Africa.
Source: ScienceDaily Headlines - November 9, 2016 Category: Science Source Type: news

Plasmodium vivax vaccine research - we've only just begun.
Abstract Plasmodium vivax parasites cause the majority of malaria cases outside Africa, and are increasingly being acknowledged as a cause of severe disease. The unique attributes of P. vivax biology, particularly the capacity of the dormant liver stage, the hypnozoite, to maintain blood-stage infections even in the absence of active transmission, make blood-stage vaccines particularly attractive for this species. However, P. vivax vaccine development remains resolutely in first gear, with only a single blood-stage candidate having been evaluated in any depth. Experience with Plasmodium falciparum suggests that a ...
Source: International Journal for Parasitology - November 26, 2016 Category: Parasitology Authors: Tham WH, Beeson JG, Rayner JC Tags: Int J Parasitol Source Type: research

Antimalarial efficacy of low molecular weight chitosan against Plasmodium berghei infection in mice.
CONCLUSION: The results of this study showed that the chitosan has potent antimalarial activity and could be suggested as an alternative antimalarial drug component. PMID: 28035107 [PubMed - in process]
Source: Journal of Vector Borne Diseases - December 31, 2016 Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research