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Therapy: Corticosteroid Therapy

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Total 62 results found since Jan 2013.

Protein tyrosine phosphatase PTPRR regulates PP2A in mononuclear cells
Conclusion: We have demonstrated that reduction of PTPRR down-regulates PP2AC via enhancement of PP2AC-Tyr307 phosphorylation that may lead to corticosteroid insensitivity. This novel mechanism may be a new therapeutic target for restoration of corticosteroid sensitivity in patients with severe asthma.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kobayashi, Y., Miller-Larsson, A., Ito, K., Kanda, A., Tomoda, K., Barnes, P. J., Mercado, N. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Activation of GX sPLA2 by Furin-like Proprotein Convertases Lipids
In this study, using a FLAG epitope-tagged pro-GX sPLA2 expression construct (FLAG-pro-GX sPLA2), we determined that adrenocorticotropic hormone (ACTH) enhanced FLAG-pro-GX sPLA2 processing and phospholipase activity secreted by Y1 adrenal cells. ACTH increased the expression of furin and PCSK6, but not other members of the PC family, in Y1 cells. Overexpression of furin and PCSK6 in HEK 293 cells significantly enhanced FLAG-pro-GX sPLA2 processing, whereas siRNA-mediated knockdown of both PCs almost completely abolished FLAG-pro-GX sPLA2 processing in Y1 cells. Expression of either furin or PCSK6 enhanced the ability of G...
Source: Journal of Biological Chemistry - March 20, 2015 Category: Chemistry Authors: Layne, J. D., Shridas, P., Webb, N. R. Tags: Cell Biology Source Type: research

Increased expression of TLR2 in CD4+ T cells from SLE patients enhances immune reactivity and promotes IL‐17 expression through histone modifications
This article is protected by copyright. All rights reserved
Source: European Journal of Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Yu Liu, Jieyue Liao, Ming Zhao, Haijing Wu, Susan Yung, Tak Mao Chan, Yoshimura Akihiko, Qianjin Lu Tags: Regular Article Source Type: research

Increased expression of TLR2 in CD4(+) T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications.
This article is protected by copyright. All rights reserved. PMID: 26079624 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - June 15, 2015 Category: Allergy & Immunology Authors: Liu Y, Liao J, Zhao M, Wu H, Yung S, Chan TM, Akihiko Y, Lu Q Tags: Eur J Immunol Source Type: research

Sphingosine 1-phosphate Increases COX-2 Expression and PGE2 Secretion: Effects on β2-adrenergic Receptor Desensitization.
Abstract Tachyphylaxis of the β2-adrenergic receptor limits the efficacy of bronchodilatory β2-agonists in respiratory disease. Cellular studies in airway smooth muscle (ASM) have shown that inflammatory mediators and infectious stimuli reduce β2-adrenergic responsiveness in a cyclooxygenase 2 (COX-2)-mediated, prostaglandin E2 (PGE2)-dependant manner. Herein we show that sphingosine 1-phosphate (S1P), a bioactive sphingolipid that plays an important role in pathophysiology of asthma, also induces β2-adrenergic receptor desensitization in bronchial ASM cells and exerts hyporesponsiveness to β2-agonist. We tre...
Source: Am J Respir Cell Mol... - June 22, 2015 Category: Respiratory Medicine Authors: Rumzhum NN, Rahman MM, Oliver BG, Ammit AJ Tags: Am J Respir Cell Mol Biol Source Type: research

Role of protein phosphatase 5 (PP5) in mediating corticosteroid insensitivity in airway smooth muscle (ASM) cells in severe asthma
Although the mechanisms mediating corticosteroid resistance in severe asthma are still unknown, recent evidence suggests ASM cells isolated from patients with severe asthma have a decreased insensitivity to dexamethasone (Dex) with respect to the inhibition of chemokine production. Here we investigated whether this corticosteroid insensitivity seen in ASM from severe asthmatics was due to an abnormal GR signalling pathway. We here observed that production of CCL5 and CCL11 by TNF in ASM cells from severe asthmatics (compared to healthy subjects and nonsevere asthma) was not affected by Dex or fluticasone (FP) pretreatment....
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Chachi, L., Abbasian, M., Gavrila, A., Tliba, O., Brightling, C., Amrani, Y. Tags: 3.2 Airway Cell Biology and Immunopathology Source Type: research

Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma
ConclusionsPP5‐dependent impairment of GRα function represents a novel mechanism driving GC insensitivity in ASM in severe asthma.This article is protected by copyright. All rights reserved.
Source: Allergy - August 9, 2016 Category: Allergy & Immunology Authors: Latifa Chachi, Mahnaz Abbassian, Adelina Gavrila, Abdulrahman Alzahrani, Omar Tliba, Peter Bradding, Andrew J. Wardlaw, Christopher Brightling, Yassine Amrani Tags: Original Article: Airway Diseases Source Type: research

LATE-BREAKING ABSTRACT: MUC1 downregulation induces corticosteroid resistance in asthma's in vitro and in vivo models
Conclusion: MUC1 downregulation may lack the anti-inflammatory effects of corticosteroids in Asthma.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Morell, A., Bel, E., Milara, J., Morcillo, E., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: informing cell-type-specific roles
The mineralocorticoid receptor (MR) mediates the actions of two important adrenal corticosteroid hormones, aldosterone and cortisol. The cell signalling roles of the MR in vivo have expanded enormously since the cloning of human MR gene 30 years ago and the first MR gene knockout in mice nearly 20 years ago. Complete ablation of the MR revealed important roles postnatally for regulation of kidney epithelial functions, with MR-null mice dying 1–2 weeks postnatally from renal salt wasting and hyperkalaemia, with elevated plasma renin and aldosterone. Generation of tissue-selective MR-deficient mice using Cre recombinas...
Source: Journal of Endocrinology - June 20, 2017 Category: Endocrinology Authors: Cole, T. J., Young, M. J. Tags: Thematic Review Source Type: research

Regulation of Corticosteroidogenic Genes by MicroRNAs.
This study demonstrates that corticosteroidogenesis is regulated at multiple points by several microRNAs and that certain of these microRNAs are differentially expressed in tumorous adrenal tissue, which may contribute to dysregulation of corticosteroid secretion. These findings provide new insights into the regulation of corticosteroid production and have implications for understanding the pathology of disease states where abnormal hormone secretion is a feature. PMID: 28852406 [PubMed]
Source: International Journal of Endocrinology - September 1, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Nrf2 Signaling Pathway Mediates the Antioxidative Effects of Taurine Against Corticosterone-Induced Cell Death in HUMAN SK-N-SH Cells.
Abstract Substantial evidence has shown that elevated circulating corticosteroids or chronic stress contributes to neuronal cell death, cognitive and mental disorders. However, the underlying mechanism is still unclear. Taurine is considered to protect neuronal cells from apoptotic cell death in neurodegenerative diseases and neuropsychiatric disorders. In the present study, the protective effects of taurine against corticosterone (CORT)-induced oxidative damage in SK-N-SH neuronal cells were investigated. The results showed that CORT significantly induced cell death, which was blocked by pretreatment with taurine...
Source: Neurochemical Research - October 23, 2017 Category: Neuroscience Authors: Sun Q, Jia N, Yang J, Chen G Tags: Neurochem Res Source Type: research

Engineering of budesonide-loaded lipid-polymer hybrid nanoparticles using a quality-by-design approach
This study shows the importance of systematic formulation design for understanding the effect of formulation parameters on the characteristics of LPNs, eventually resulting in the identification of an OOS.Graphical abstract
Source: International Journal of Pharmaceutics - July 25, 2018 Category: Drugs & Pharmacology Source Type: research

Th1 Cytokines, TNF α and IFNγ, Promote Corticosteroid Resistance in Developing Human Airway Smooth Muscle.
Th1 Cytokines, TNFα and IFNγ, Promote Corticosteroid Resistance in Developing Human Airway Smooth Muscle. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 18;: Authors: Britt RD, Thompson MA, Sasse SK, Pabelick CM, Gerber AN, Prakash YS Abstract Corticosteroids are commonly used to manage wheezing and asthma in pediatric populations. Although corticosteroids are effective in alleviating airway diseases, some children with more moderate-severe asthma phenotypes show corticosteroid (CS) resistance and exhibit significant airflow obstruction, persistent inflammation, and more frequent exacerbations. Previo...
Source: Am J Physiol Lung Ce... - October 18, 2018 Category: Respiratory Medicine Authors: Britt RD, Thompson MA, Sasse SK, Pabelick CM, Gerber AN, Prakash YS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Club Cell Protein-16 modifies airway inflammation in asthma and is associated with significant clinical asthma outcomes
Conclusion: Lack of CC16 results in enhanced T2 inflammatory responses in both human primary cell culture and a mouse model. CC16 mRNA levels inversely correlated with MUC5AC which was supported by the CC16 knockdown experiments, and significantly associated with clinically relevant asthma outcomes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kraft, M., Ledford, J., Gozdz, J., Li, X., Francisco, D., Manne, A., Guerra, S., Martinez, F., Kaminski, N., Wenzel, S., Meyers, D., Bleecker, E. Tags: Clinical Problems Source Type: research

Th1 cytokines TNF- α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle.
Th1 cytokines TNF-α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 01;316(1):L71-L81 Authors: Britt RD, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS Abstract Corticosteroids (CSs) are commonly used to manage wheezing and asthma in pediatric populations. Although corticosteroids are effective in alleviating airway diseases, some children with more moderate-severe asthma phenotypes show CS resistance and exhibit significant airflow obstruction, persistent inflammation, and more frequent exacerbations. Previ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 19, 2018 Category: Cytology Authors: Britt RD, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research