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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Effects of 25-hydroxyvitamin D3 on cathelicidin production and antibacterial function of human oral keratinocytes.
In this study, we investigated the regulation of antibacterial functions of oral keratinocyte cells by 25-hydroxyvitamin D3 (25VD3). OKF6/TERT2 cells, an immortalized human oral keratinocyte cell line, were transfected with or without 24-hydroxylase small interfering RNA (siRNA) and incubated with different amounts of 25VD3. These epithelial cells expressed high levels of inactivating 24-hydroxylase (CYP24A1) and relatively low levels of activating 1α-hydroxylase (CYP27B1) in the presence of 25VD3. 25VD3 influenced the expression of vitamin D-driven genes and cathelicidin in a dose-related manner. SiRNA specific to 24-hyd...
Source: Cellular Immunology - June 19, 2013 Category: Allergy & Immunology Authors: Wang Q, Zhang W, Li H, Aprecio R, Wu W, Lin Y, Li Y Tags: Cell Immunol Source Type: research
Reciprocal modulation of C/EBPα and C/EBPβ by IL-13 in activated microglia prevents neuronal death.
This article is protected by copyright. All rights reserved.
PMID: 23881867 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - July 23, 2013 Category: Allergy & Immunology Authors: Pan HC, Yang CN, Hung YW, Lee WJ, Tien HR, Shen CC, Sheehan J, Chou CT, Sheu ML Tags: Eur J Immunol Source Type: research
AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice
Conclusions: The Fyn-regulated LKB1-AMPK axis acts as a novel inhibitory module for mast cell activation, which points to AMPK activators as therapeutic drugs for allergic diseases.
Source: Journal of Allergy and Clinical Immunology - April 15, 2013 Category: Allergy & Immunology Authors: Seung-Lark Hwang, Xian Li, Yue Lu, Ye Jin, Yong-Tae Jeong, Yong Deuk Kim, In-Kyu Lee, Yoshitaka Taketomi, Hiroyasu Sato, You Sook Cho, Makoto Murakami, Hyeun Wook Chang Tags: Mechanisms of allergy and clinical immunology Source Type: research
Differential expression of 11β‐hydroxysteroid dehydrogenase type 1 and 2 in mild and moderate/severe persistent allergic nasal mucosa and regulation of their expression by Th2 cytokines
Conclusions and Clinical RelevanceThese results indicate that the localized anti‐inflammatory effects of glucocorticoids are regulated by inflammatory cytokines, which can modulate the expression of 11β‐HSD1, 11β‐HSD2, CYP11B1, and by the intracellular concentrations of bioactive glucocorticoids.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 1, 2013 Category: Allergy & Immunology Authors: Young Joon Jun, Se Jin Park, Jae Woong Hwang, Tae Hoon Kim, Kwang Jin Jung, Jong Yoon Jung, Gyu Ho Hwang, Seung Hoon Lee, Sang Hag Lee Tags: Original Article‐Basic Mechanisms in Allergic Disease Source Type: research
AMP-activated protein kinase negatively regulates FcεRI-mediated mast cell signaling and anaphylaxis in mice
Conclusions: The Fyn-regulated LKB1-AMPK axis acts as a novel inhibitory module for mast cell activation, which points to AMPK activators as therapeutic drugs for allergic diseases.
Source: Journal of Allergy and Clinical Immunology - April 15, 2013 Category: Allergy & Immunology Authors: Seung-Lark Hwang, Xian Li, Yue Lu, Ye Jin, Yong-Tae Jeong, Yong Deuk Kim, In-Kyu Lee, Yoshitaka Taketomi, Hiroyasu Sato, You Sook Cho, Makoto Murakami, Hyeun Wook Chang Tags: Mechanisms of allergy and clinical immunology Source Type: research
Down‐Regulation of TIMP3 Leads to Increase in TACE Expression and TNFα Production by Placental Trophoblast Cells
ConclusionAs TIMP3 is an endogenous TACE inhibitor, down‐regulation of trophoblast TIMP3 expression/activity could result in increased TACE expression and subsequently lead to increased TNFα production in preeclamptic placentas.
Source: American Journal of Reproductive Immunology - February 4, 2014 Category: Allergy & Immunology Authors: Rong Ma, Baihan Gu, Yang Gu, Lynn J. Groome, Yuping Wang Tags: Original Article Source Type: research
Role of cathepsin B in regulating migration and invasion of fibroblast‐like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
Abstract
Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast‐like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviors of RA‐FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by qPCR and immunohistochemistry (IHC), respectively. Stable depletion of endogenous CB was achieved by siRNA transfection, and decrease of CB activity was acquired ...
Source: Clinical and Experimental Immunology - April 22, 2014 Category: Allergy & Immunology Authors: Bei Tong, Bin Wan, Zhifeng Wei, Ting Wang, Peng Zhao, Yannong Dou, Zheng Lv, Yue Dai, Yufeng Xia Tags: Original Article Source Type: research
Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis.
Abstract
Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast-like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviors of RA-FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by qPCR and immunohistochemistry (IHC), respectively. Stable depletion of endogenous CB was achieved by siRNA transfection, and decrease of CB activity was acqu...
Source: Clinical and Developmental Immunology - April 22, 2014 Category: Allergy & Immunology Authors: Tong B, Wan B, Wei Z, Wang T, Zhao P, Dou Y, Lv Z, Dai Y, Xia Y Tags: Clin Exp Immunol Source Type: research
Effect of CD95 on inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.
CONCLUSION: Stimulation of CD95 could promote RA-FLS proliferation and inflammation, and activation of the PI3K/Akt signaling pathway might be the possible mechanism.
PMID: 25084560 [PubMed - as supplied by publisher]
Source: Cellular Immunology - July 21, 2014 Category: Allergy & Immunology Authors: Li X, Zhang Z, Peng A, He M, Xu J, Shen S, Zhuang J, Huang X Tags: Cell Immunol Source Type: research
Impact of suppressing RORγt in ameliorating central nervous system autoimmunity
In this study, we characterized the correlation between RORγt expression and other factors affecting T cell encephalitogenicity and evaluated the therapeutic potential of targeting RORγt by siRNA inhibition of RORγt. Our data showed that RORγt expression correlates with IL‐17 production, but not with the encephalitogenicity of myelin‐specific CD4 T cells. IL‐23, a cytokine that enhances encephalitogenicity, does not enhance RORγt expression significantly. Additionally, GM‐CSF levels, which correlate with the encephalitogenicity of different myelin‐specific CD4 T cell populations, do not correlate with RORγt...
Source: Clinical and Experimental Immunology - August 20, 2014 Category: Allergy & Immunology Authors: Yuhong Yang, Ryan Winger, Priscilla W. Lee, Patrick K Nuro‐Gyina, Alexa Minc, Michelle Larson, Yue Liu, Wei Pei, Elizabeth Rieser, Michael K. Racke, Amy E. Lovett‐Racke Tags: Original Article Source Type: research
Impact of suppressing RORγt in ameliorating central nervous system autoimmunity.
In this study, we characterized the correlation between RORγt expression and other factors affecting T cell encephalitogenicity and evaluated the therapeutic potential of targeting RORγt by siRNA inhibition of RORγt. Our data showed that RORγt expression correlates with IL-17 production, but not with the encephalitogenicity of myelin-specific CD4 T cells. IL-23, a cytokine that enhances encephalitogenicity, does not enhance RORγt expression significantly. Additionally, GM-CSF levels, which correlate with the encephalitogenicity of different myelin-specific CD4 T cell populations, do not correlate with RORγt. More imp...
Source: Clinical and Developmental Immunology - August 20, 2014 Category: Allergy & Immunology Authors: Yang Y, Winger R, Lee PW, Nuro-Gyina PK, Minc A, Larson M, Liu Y, Pei W, Rieser E, Racke MK, Lovett-Racke AE Tags: Clin Exp Immunol Source Type: research
PI3K and Akt are required for RIG-I-mediated anti-viral signaling through crosstalk with IPS-1.
This article is protected by copyright. All rights reserved.
PMID: 25158146 [PubMed - as supplied by publisher]
Source: Immunology - August 26, 2014 Category: Allergy & Immunology Authors: Yeon SH, Song MJ, Kang HR, Lee JY Tags: Immunology Source Type: research
Monocyte‐derived fibrocytes induce an inflammatory phenotype in airway smooth muscle cells
ConclusionFC promoted IL‐8 and IL‐6 production by ASMC, demonstrating a proinflammatory role for FC and a possible mechanism of the inflammatory phenotype in asthma.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - September 25, 2014 Category: Allergy & Immunology Authors: Ting‐Yu Lin, Narayanan Venkatesan, Michiyoshi Nishioka, Shigenori Kyoh, Laila Al‐Alwan, Carolyn J. Baglole, David H. Eidelman, Mara S. Ludwig, Qutayba Hamid Tags: Original Article‐Basic Mechanisms in Allergic Disease Source Type: research
Cyclin-Dependent Kinase 5 Regulates Degranulation in Human Eosinophils.
This article is protected by copyright. All rights reserved.
PMID: 25346443 [PubMed - as supplied by publisher]
Source: Immunology - October 26, 2014 Category: Allergy & Immunology Authors: Odemuyiwa SO, Ilarraza R, Davoine F, Logan MR, Shayeganpour A, Wu Y, Majaesic C, Adamko DJ, Moqbel R, Lacy P Tags: Immunology Source Type: research
Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus
Publication date: May 2013 Source:Molecular Immunology, Volume 54, Issue 1 Author(s): Nicholas A. Young , Alexandra K. Friedman , Benjamin Kaffenberger , Murugesan V.S. Rajaram , Daniel J. Birmingham , Brad H. Rovin , Lee A. Hebert , Larry S. Schlesinger , Lai-Chu Wu , Wael N. Jarjour Systemic lupus erythematosus (SLE) is a prototypic, inflammatory autoimmune disease characterized by significant gender bias. Previous studies have established a role for hormones in SLE pathogenesis, including the sex hormone estrogen. Estrogen regulates gene expression by translocating estrogen receptors (ER) α and β into the nucleus wh...
Source: Molecular Immunology - November 3, 2014 Category: Allergy & Immunology Source Type: research
