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Total 94 results found since Jan 2013.

Kaposi's sarcoma associated with adult dermatomyositis
We report a case involving a 73-year-old Saudi man diagnosed with dermatomyositis who subsequently developed Kaposi's sarcoma one month later. He had difficulty in rising from a chair and increased leg weakness while climbing stairs or walking. He was unable to comb his hair and had greater dysphagia with liquids than with solid foods. Laboratory tests showed elevated liver enzyme and creatine kinase levels. Right quadriceps muscle biopsy indicated inflammatory myopathy, which was consistent with adult dermatomyositis. We administered 1-g/day methylprednisolone intravenously for 3 days, followed by 60-mg oral prednisolone ...
Source: Saudi Medical Journal - April 26, 2021 Category: Middle East Health Authors: Khawla K Alghanim Batol G Gasmelseed Source Type: research

Cancers, Vol. 12, Pages 3810: The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction
mma Rybalka Chemotherapy-induced muscle wasting and dysfunction is a contributing factor to cachexia alongside cancer and increases the risk of morbidity and mortality. Here, we investigate the effects of the chemotherapeutic agent irinotecan (IRI) on skeletal muscle mass and function and whether BGP-15 (a poly-(ADP-ribose) polymerase-1 (PARP-1) inhibitor and heat shock protein co-inducer) adjuvant therapy could protect against IRI-induced skeletal myopathy. Healthy 6-week-old male Balb/C mice (n = 24; 8/group) were treated with six intraperitoneal injections of either vehicle, IRI (30 mg/kg) or BGP-15 adjuvant therapy...
Source: Cancers - December 17, 2020 Category: Cancer & Oncology Authors: Dean G. Campelj Cara A. Timpani Aaron C. Petersen Alan Hayes Craig A. Goodman Emma Rybalka Tags: Article Source Type: research

An extragonadal germ cell tumor with dermatomyositis: A case report and literature review.
Abstract The risk of malignancy in inflammatory myopathy patients is well recognized. However, the incidence of germ cell tumor (GCT) with inflammatory myopathy is low, and most reported cases of GCT also exhibit testicular tumors. Therefore, a case of extragonadal GCT with dermatomyositis (DM) is reported in the current study to better understand this paraneoplastic syndrome. A 53-year-old man presented with bilateral cervical lymph node enlargement. A lymph node biopsy showed embryonal carcinoma, and computed tomography showed multiple lymph node and lung metastases. A period of one month after bleomycin, etopos...
Source: Clinical Lung Cancer - September 22, 2020 Category: Cancer & Oncology Authors: Fujiwara Y, Fukuda N, Ohmoto A, Nakano K, Ono M, Taira S, Torii J, Takamatsu M, Takahashi S Tags: Mol Clin Oncol Source Type: research

Light ‐chain amyloid myopathy isolated to skeletal muscles: A case report
Isolated amyloidosis, especially of amyloid light ‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin. AbstractIsolated amyloidosis, especially of amyloid light ‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.
Source: Clinical Case Reports - September 7, 2020 Category: General Medicine Authors: Toshihiro Matsukawa, Katsuki Eguchi, Ichizo Nishino, Kohei Okada, Kazuo Oshimi, Takuto Miyagishima Tags: CASE REPORT Source Type: research

ATI-2173, A Novel Liver-Targeted Non-Chain Terminating Nucleotide for HBV Cure Regimens.
Abstract ATI-2173 is a novel liver-targeted molecule designed to deliver the 5'-monophosphate of clevudine for the treatment of chronic hepatitis B. Unlike other nucleos(t)ides, the active clevudine-5'-triphosphate is a noncompetitive, non-chain terminating inhibitor of HBV polymerase that delivers prolonged reduction of viremia in both a woodchuck HBV model and in humans up to six months after cessation of treatment. However, long-term clevudine treatment was found to exhibit reversible skeletal myopathy in a small subset of patients and was subsequently discontinued from development. ATI-2173 was designed by mod...
Source: Antimicrobial Agents and Chemotherapy - June 14, 2020 Category: Microbiology Authors: Squires KE, Mayers DL, Bluemling GR, Kolykhalov AA, Guthrie DB, Reddy P, Mitchell DG, Saindane MT, Sticher ZM, Edpuganti V, De La Rosa A Tags: Antimicrob Agents Chemother Source Type: research

Muscle aches and pains: do I have leukemia?
We describe a 65-year-old man who presented with 'aches and pains' localized to the lower extremities, and was diagnosed with acute myeloid leukemia (AML). We hypothesize that this case represents an atypical presentation of AML with an immune-mediated necrotizing-like myopathy as a possible paraneoplastic manifestation of the disease, which improved after initiating chemotherapy. Our patient received a full course of 7 + 3 chemotherapy with cytarabine and daunorubicin. Proximal leg weakness and pain improved markedly following this treatment, establishing a temporal relationship between the possible paraneoplastic man...
Source: International Journal of Hematology - October 13, 2019 Category: Hematology Authors: Deschner M, Phua C, Saini L, Xenocostas A, Deotare U Tags: Int J Hematol Source Type: research

PD1 pathway in immune-mediated myopathies: Pathogenesis of dysfunctional T cells revisited
Conclusion Persistent exposure to antigens in IMNMs and sIBM may lead to T-cell exhaustion, a process controlled by the PD1 receptor and its cognate ligands PD-L1/PD-L2. To our knowledge, these data are the first evidence of presence of dysfunctional T cells and relevance of the PD1 pathway in IMNM, sIBM, and irMyositis. These findings may guide the way to a novel understanding of the immune pathogenesis of immune-mediated myopathies.
Source: Neurology Neuroimmunology and Neuroinflammation - April 9, 2019 Category: Neurology Authors: Knauss, S., Preusse, C., Allenbach, Y., Leonard-Louis, S., Touat, M., Fischer, N., Radbruch, H., Mothes, R., Matyash, V., Böhmerle, W., Endres, M., Goebel, H.-H., Benveniste, O., Stenzel, W. Tags: All Immunology, All Neuromuscular Disease, Chemotherapy-tumor Article Source Type: research

Hydrocarbon Stapled Peptides that Inhibit the Linear Ubiquitin Chain Assembly Complex (LUBAC) for the Therapy of the Activated B Cell-like (ABC) Subtype of Diffuse Large B Bell Lymphoma (A Type of Non-Hodgkin ’s Lymphoma)
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin ’s lymphoma and consists of three subtypes: activated B-cell (ABC), germinal center B-cell (GBC), and primary mediastinal B-cell (PMB). Despite advances in the front-line therapy for DLBCL, approximately one-third of patients will relapse. Substantially worse outcomes have been reported for patien ts diagnosed with ABC DLBCL and treated with standard chemoimmunotherapy, suggesting the need for novel strategies that improve treatment outcomes.ABC DLBCL cell survival depends largely upon NF- κB signaling being constitutively active. The linear ub...
Source: NIH OTT Licensing Opportunities - December 20, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Anti-NXP2-antibody-positive immune-mediated necrotizing myopathy associated with acute myeloid leukemia: A case report
Rationale: Idiopathic inflammatory myopathies have been extensively reported associated with malignancy. Immune-mediated necrotizing myopathy (IMNM), however, has rarely been connected with malignancy including acute myeloid leukemia (AML). Patient concerns: A 65-year-old woman was diagnosed with AML and received regular chemotherapy. After the 5th cycle chemotherapy, she achieved complete remission but developed severe muscle weakness and myalgia with dramatic increasing creatine kinase (CK). Diagnosis: The positivity of antinuclear matrix protein 2 antibody (anti-NXP2 Ab) and muscle biopsy in together confirmed t...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Chemical, biochemical, preclinical and clinical studies of Ganoderma lucidum polysaccharide as an approved drug for treating myopathy and other diseases in China.
Abstract Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for more than 2000 years. G. lucidum polysaccharide (GLPS) has been identified as one of the major bioactive components and developed into a drug named "Ji 731 Injection" in China since 1973. The large-scale production of the drug began in 1985 and approved by the Chinese FDA as "Polysaccharidum of G. lucidum Karst Injection" (Ling Bao Duo Tang Zhu She Ye) in 2000, which is applied intramuscularly. After more than forty years of clinical use, its...
Source: J Cell Mol Med - April 24, 2018 Category: Molecular Biology Authors: Zeng P, Guo Z, Zeng X, Hao C, Zhang Y, Zhang M, Liu Y, Li H, Li J, Zhang L Tags: J Cell Mol Med Source Type: research

Chemotherapy with stem cell transplantation is more effective than immunotherapy in sporadic late onset nemaline myopathy with monoclonal gammopathy
Chemotherapy with stem cell transplantation is more effective than immunotherapy in sporadic late onset nemaline myopathy with monoclonal gammopathy, Published online: 24 January 2018; doi:10.1038/s41409-017-0080-6Chemotherapy with stem cell transplantation is more effective than immunotherapy in sporadic late onset nemaline myopathy with monoclonal gammopathy
Source: Bone Marrow Transplantation - January 24, 2018 Category: Hematology Authors: Rouslan Kotchetkov Anna Dyszkiewicz-Korpanty Vishal Kukreti Source Type: research

How can we effectively address the paraneoplastic dermatomyositis: Diagnosis, risk factors and treatment options.
CONCLUSIONS: Timely diagnosis coupled with a treatment plan focused on muscular endurance and improvement of skin lesions and other symptoms offer a favorable response to therapy along with the achievement of a higher quality of life for these patients. PMID: 28952230 [PubMed - in process]
Source: Journal of B.U.ON. - September 29, 2017 Category: Cancer & Oncology Tags: J BUON Source Type: research