PD1 pathway in immune-mediated myopathies: Pathogenesis of dysfunctional T cells revisited

Conclusion
Persistent exposure to antigens in IMNMs and sIBM may lead to T-cell exhaustion, a process controlled by the PD1 receptor and its cognate ligands PD-L1/PD-L2. To our knowledge, these data are the first evidence of presence of dysfunctional T cells and relevance of the PD1 pathway in IMNM, sIBM, and irMyositis. These findings may guide the way to a novel understanding of the immune pathogenesis of immune-mediated myopathies.

Source: Neurology Neuroimmunology and Neuroinflammation - April 9, 2019 Category: Neurology Authors: Knauss, S., Preusse, C., Allenbach, Y., Leonard-Louis, S., Touat, M., Fischer, N., Radbruch, H., Mothes, R., Matyash, V., Böhmerle, W., Endres, M., Goebel, H.-H., Benveniste, O., Stenzel, W. Tags: All Immunology, All Neuromuscular Disease, Chemotherapy-tumor Article Source Type: research