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Vaccination: Influenza Vaccine

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Total 364 results found since Jan 2013.

Unique influenza A  cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion
There is extensive direct evidence in murine viral challenge studies that heterologous immunity facilitated by cross-reactive CD8 T-cell responses can mediate either beneficial or detrimental effects.1 Studies defining the role of heterologous immunity during human viral infection are more challenging. A  classic example of protective heterologous immunity in humans is smallpox vaccination. Immunological memory to vaccinia virus (cowpox) protects against human smallpox (variola) infection. More recent studies have shown that children vaccinated with live measles virus or Bacille-Calmette-Guerin hav e unexpectedly lower su...
Source: Journal of Allergy and Clinical Immunology - June 16, 2017 Category: Allergy & Immunology Authors: Levi B. Watkin, Rabinarayan Mishra, Anna Gil, Nuray Aslan, Dario Ghersi, Katherine Luzuriaga, Liisa K. Selin Tags: Letter to the Editor Source Type: research

High-dose Flu Vaccine Cuts Hospitalizations for Nursing Home Residents High-dose Flu Vaccine Cuts Hospitalizations for Nursing Home Residents
Compared with standard-dose influenza vaccination, high-dose influenza vaccination reduces the number of U.S. nursing home residents who require respiratory-related hospital admissions, according to results from a cluster-randomized trial.Reuters Health Information
Source: Medscape Allergy Headlines - August 2, 2017 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news

Development of a Transferrable Norwalk Virus Epitope and Detector Monoclonal Antibody
Noroviruses are now recognized as the major cause of non-bacterial gastroenteritis in all age groups, and efforts are underway to develop an effective vaccine. The lack of a robust cell culture system for human noroviruses has complicated vaccine development. Hence, norovirus virus like particles (VLPs) have played an important role in the understanding of virus structure, immune response, antigenic diversity, and vaccine design. The development of monoclonal antibodies (MAbs) against norovirus VLPs has allowed the identification and characterization of key antigenic sites of the virus capsid and facilitated the developmen...
Source: NIH OTT Licensing Opportunities - August 24, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

Impaired Humoral and Cellular Immune Responses to Influenza Vaccination in COPD Patient
Source: Journal of Allergy and Clinical Immunology - September 7, 2017 Category: Allergy & Immunology Authors: Aur élien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge A Source Type: research

Impaired humoral and cellular immune responses to influenza vaccination in chronic obstructive pulmonary disease patients
Exacerbations are the main sources of hospitalization and mortality in patients with chronic obstructive pulmonary disease (COPD). They are related chiefly to lung infections,1 of which 36% are due to influenza viruses.2,3 Exacerbations triggered by viral infections are usually more severe than those related to bacterial infections, with a longer recovery time and a higher admission rate.1 Although influenza vaccination of patients with COPD is recommended in many countries, the immune response to the vaccine in this population has not been studied in detail.
Source: Journal of Allergy and Clinical Immunology - September 7, 2017 Category: Allergy & Immunology Authors: Aur élien Parpaleix, Laurent Boyer, Aurelie Wiedemann, Christine Lacabaratz, Laurent Margarit, Vincent Enouf, Philippe Le Corvoisier, Anne Lino, Ala Covali-Noroc, Bruno Housset, Christos Chouaid, Bernard Maitre, Yves Lévy, Jean-Daniel Lelièvre, Serge A Tags: Letter to the Editor Source Type: research

Influenza Vaccination in Patients with Common Variable Immunodeficiency (CVID)
AbstractPurpose of ReviewVaccination against influenza in patients with primary antibody deficiency is recommended. Common variable immunodeficiency (CVID) is the most frequent and clinically relevant antibody deficiency disease and is by definition characterized by an impaired vaccination response. The purpose of this review is to present the current knowledge of humoral and cellular vaccine response to influenza in CVID patients.Recent FindingsStudies conducted in CVID patients demonstrated an impaired humoral response upon influenza vaccination. Data on cellular immune response are in part conflicting, with two out of t...
Source: Current Allergy and Asthma Reports - October 5, 2017 Category: Allergy & Immunology Source Type: research

A 58-Year-Old Woman With Pneumonia and Gram-Negative Diplococci.
Abstract CASE PRESENTATION: A 58-year-old woman with COPD, cor pulmonale, diabetes, and hypertension had a productive cough of greenish and purulent sputum, low-grade fever, and shortness of breath. Medications were metformin, losartan, cholecalciferol, folic acid, a multivitamin, fluticasone by inhalation, and, as needed, ipratropium by inhalation. She lived alone and worked as a physician, had received that year's seasonal influenza vaccine, was a heavy smoker, did not drink alcohol or use illicit drugs, and had no personal or family history of allergy and autoimmunity. PMID: 28991556 [PubMed - in process]
Source: Chest - October 1, 2017 Category: Respiratory Medicine Authors: Famularo G, Sordillo P, Stasolla A, Parisi MG Tags: Chest Source Type: research

Neutralizing Antibodies to Influenza HA and Their Use and Identification
The effectiveness of current influenza vaccines varies by strain and season, in part because influenza viruses continuously evolve to evade human immune responses. While the majority of seasonal influenza infections cause relatively mild symptoms, each year influenza virus infections result in over 500,000 hospitalizations in the United States and Europe. Current standard of care for individuals hospitalized with uncomplicated influenza infection is administration of neuraminidase inhibitors. However, frequent use of such antiviral drugs increases the risk that the virus will develop drug resistance, especially in high-ris...
Source: NIH OTT Licensing Opportunities - October 30, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research

Influenza burden, prevention and treatment in asthma – a scoping review by the EAACI Influenza in Asthma Task Force
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Source: Allergy - November 6, 2017 Category: Allergy & Immunology Authors: J ürgen Schwarze, Peter Openshaw, Akhilesh Jha, Stefano R del Giacco, Davide Firinu, Olympia Tsilochristou, Graham Roberts, Anna Selby, Cezmi Akdis, Ioana Agache, Adnan Custovic, Enrico Heffler, Georgia Pinna, Musa Khaitov, Alexandra Nikonova, Nikolaos P Tags: Review Article Source Type: research

Experts Concerned About Effectiveness Of This Year ’ s Flu Vaccine
(CNN) — Last year’s seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, people had inadequate protection against the flu. This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today. This year’s flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate profe...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 8, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Flu Flu Vaccine Local TV Source Type: news

Comparison of Different Methods of Purification and Concentration in Production of Influenza Vaccine
The overwhelming majority of influenza vaccines are prepared with the use of chicken embryo allantoic fluid. The presence of ovalbumin (this protein constitutes>60% total protein in the allantoic fluid) in the vaccine can lead to severe allergy. Hence, effective reduction of ovalbumin content is of crucial importance for vaccine production. We compared two methods of purification and concentration of influenza virus: zonal gradient ultracentrifugation and combined ultrafiltration/diafiltration and exclusion chromatography protocol, used for fabrication of seasonal vaccines. Combined chromatography is comparable with zon...
Source: Bulletin of Experimental Biology and Medicine - November 25, 2017 Category: Biology Source Type: research

Australia's flu season has U.S. health officials bracing for a bad winter — and wishing for a new vaccine
The flu season is just getting underway in North America, but if Australia ’s experience with influenza is any guide, we’re in for a miserable winter.Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases,warned Wednesday that the United States could experience...
Source: Los Angeles Times - Science - November 30, 2017 Category: Science Authors: Melissa Healy Source Type: news

Factors influencing on influenza vaccination among south korean adult asthma: a nationwide population-based cross-section study
Conclusions: Attention and interventions are required to improve the influenza vaccination coverage for the non-elderly patients with asthma, especially on those who are taking no regular exercise, thinking self as being healthy, taking irregular health check-up.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Han, C. H., Chung, J. H. Tags: Allergy and immunology Source Type: research

MPO-ANCA associated vasculitis with mononeuritis multiplex following influenza vaccination
Although influenza vaccines are generally safe and effective, a variety of autoimmune phenomena have been reported after vaccination over the past years, such as Guillain –Barre syndrome, rheumatoid arthritis, ...
Source: Allergy, Asthma and Clinical Immunology - December 13, 2017 Category: Allergy & Immunology Authors: Stefanie Eindhoven, Jolien Levels, Margriet Huisman, Koos Ruizeveld de Winter, Virgil Dalm and Rehmat Alwani Tags: Case Report Source Type: research

Flu infection study increases understanding of natural immunity
(NIH/National Institute of Allergy and Infectious Diseases) People with higher levels of antibodies against the stem portion of the influenza virus hemagglutinin (HA) protein have less viral shedding when they get the flu, but don't have fewer or less severe signs of illness, according to a new study. This NIAID study is the first of its kind to evaluate pre-existing levels of these antibodies as a predictor of protection against influenza. The findings could have implications for flu vaccine development.
Source: EurekAlert! - Infectious and Emerging Diseases - January 23, 2018 Category: Infectious Diseases Source Type: news