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Procedure: Skin Biopsy

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Total 252 results found since Jan 2013.

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Phase 1 healthy volunteer willingness to participate and enrollment preferences.
CONCLUSION: Our results suggest that healthy volunteers are willing to participate in a wide range of types of phase 1 clinical trials, and express preferences for low risk and familiar studies and study procedures, preferences which are partially affected by offers of payment. PMID: 28766409 [PubMed - as supplied by publisher]
Source: Clinical Trials - August 1, 2017 Category: Research Authors: Chen SC, Sinaii N, Bedarida G, Gregorio MA, Emanuel E, Grady C Tags: Clin Trials Source Type: research

Are metals involved in tattoo ‐related hypersensitivity reactions? A case report
ConclusionThe patient's hypersensitivity reaction and its spontaneous remission after removal of the implants indicate that Ti, possibly along with some of the other metals detected, could have played a major role in this particular case of tattoo‐related allergy.
Source: Contact Dermatitis - August 9, 2017 Category: Dermatology Authors: Christa de Cuyper, Evelyne Lodewick, Ines Schreiver, Bernhard Hesse, Christian Seim, Hiram Castillo ‐Michel, Peter Laux, Andreas Luch Tags: Original Article Source Type: research

Histopathology of Urticaria
Opinion statementPurpose of reviewUrticaria is a common skin manifestation with many different causes. It is characterized by local or generalized edematous erythema with itching and increased blood flow and vascular permeability. Individual urticaria lesions typically last less than 24 h (usually less than 12 h), but new lesions may appear and resolve sporadically. Since the diagnosis is usually made based on the history and clinical appearance of the lesions, skin biopsy is not necessarily performed, but it is recommended for evaluating patients with refractory eruptions or su spicion of other diseases exhibiting urti...
Source: Current Treatment Options in Allergy - September 8, 2017 Category: Allergy & Immunology Source Type: research

124 Desmoplakin mutation in neonatal erythroderma
A neonatal boy presented with ichthyosiform erythroderma, hypotrichosis, recurrent sepsis and skin infections, failure to thrive, constant vomiting and brain abnormalities. He had persistent thrombocytosis, hypoalbunemia and hypernatremia. IgE levels rose at age 0.6 years (985 kU/l) without eosinophilia. Cow milk allergy was diagnosed at 0.7 years. IVIG treatment from 0.6 years reduced infections and acitretin from age 0.7 years reduced scaling. Skin biopsy showed a psoriformic reaction with normal LEKTI but absent filaggrin staining.
Source: Journal of Investigative Dermatology - September 8, 2017 Category: Dermatology Authors: K. Hannula-Jouppi, S. Kostjukovitch, L. Puhakka, H. Saxen, A. Ranki Tags: Epidermal Structure and Function Source Type: research

Eosinophilic esophagitis: current evidence-based diagnosis and treatment in children and adults.
Authors: Lucendo AJ Abstract Eosinophilic esophagitis (EoE) is a disease caused by an immune response to food antigens in contact with the esophageal mucosa that has arisen as a common disorder in current clinical practice. Its diagnosis is defined by the combination of symptoms of esophageal dysfunction and inflammation of the esophageal mucosa predominantly by eosinophils. Its chronic course and frequent progression to subepithelial fibrosis leading to strictures and narrow-caliber esophagus indicate the need for treatment. Information provided by recent clinical trials and systematic reviews allowed for the deve...
Source: Minerva Gastroenterologica e Dietologica - September 14, 2017 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Alopecia areata is characterized by expansion of circulating Th2/Tc2/Th22, within the skin ‐homing and systemic T‐cell populations
ConclusionsAA is accompanied by Th2/Tc2 activation in skin homing and systemic subsets, correlating with disease severity, while IFN‐γ is linked to disease chronicity. These data hint for a possible role of diverse T‐cells subsets in disease pathogenesis, and emphasize the systemic nature of AA supporting the need for systemic therapeutic strategies in severe patients.This article is protected by copyright. All rights reserved.
Source: Allergy - October 30, 2017 Category: Allergy & Immunology Authors: Tali Czarnowicki, Helen Y He, Huei ‐Chi Wen, Peter W Hashim, John K Nia, Kunal Malik, Yeriel Estrada, Grace W Kimmel, Mark Taliercio, James G Krueger, Emma Guttman‐Yassky Tags: Original Article: Skin and Eye Diseases Source Type: research

Schnitzler syndrome with IgG gammopathy and elevated IL-1 β and IL-17 in skin biopsy
We report a case of Schnitzler syndrome associated with IgG gammopathy and increased expression of interleukin (IL)-1 β and IL-17 by immunohistochemistry at skin biopsy examination.
Source: Annals of Allergy, Asthma and Immunology - November 20, 2017 Category: Allergy & Immunology Authors: Raul S. Villarreal, Timothy VandenBoom, Francisco J. Gonzalez-Gonzalez, Roderick G. Carter, Neill T. Peters, Anju T. Peters, Sergio E. Chiarella Tags: Letter Source Type: research

An imported case of leprosy in a trainee from Indonesia to Japan
A 33-year-old Indonesian man who was visiting Japan as a trainee in agricultural sector presented to the outpatient department of dermatology with a 1-year history of progressive rash. The rash had originated on his trunk and had gradually spread to his chest, abdomen, back and arms (Figure 1). The patient was not on any medications. He also denied any history of an allergy. Polymorphic, confluent, partially raised, hypopigmented macules that had progressed slowly were observed. The lesions demonstrated associated scaling, alopecia, and anesthesia. Although a left greater auricular nerve enlargement was detected, the patie...
Source: QJM - July 19, 2017 Category: Internal Medicine Source Type: research

Histomorphology and Immunophenotype of Eczematous Skin Lesions Revisited—Skin Biopsies Are Not Reliable in Differentiating Allergic Contact Dermatitis, Irritant Contact Dermatitis, and Atopic Dermatitis
Abstract: Lesions of allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), and atopic dermatitis (AD) share similar clinical features and thus, their diagnosis can be challenging. The aim of this study was to reassess histopathology and immunophenotyping properties to distinguish between ACD, ICD, and AD. Charts of patients with eczema, who had undergone complete routine diagnostic workup (skin biopsies, patch tests, skin prick tests, and respectively or serum IgE levels), were reviewed. Thirty-five skin biopsy specimens of 28 patients (mean age 64 ± 15 years; ♀ = 13 ♂ = 15) with clear diagnosis of A...
Source: The American Journal of Dermatopathology - December 30, 2017 Category: Pathology Tags: Original Study Source Type: research

Minimally invasive skin tape strip RNA-seq identifies novel characteristics of type 2-high atopic dermatitis disease endotype
Expression profiling of skin biopsies has established molecular features of the skin in atopic dermatitis (AD). Invasiveness of biopsies has prevented their use in defining individual level AD pathobiological mechanisms (endotypes) in large research studies.
Source: Journal of Allergy and Clinical Immunology - January 5, 2018 Category: Allergy & Immunology Authors: Nathan Dyjack, Elena Goleva, Cydney Rios, Byung Eui Kim, Lianghua Bin, Patricia Taylor, Caroline Bronchick, Clifton F. Hall, Brittany N. Richers, Max A. Seibold, Donald Y. Leung Source Type: research

Histomorphology and Immunophenotype of Eczematous Skin Lesions Revisited—Skin Biopsies Are Not Reliable in Differentiating Allergic Contact Dermatitis, Irritant Contact Dermatitis, and Atopic Dermatitis
Abstract: Lesions of allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), and atopic dermatitis (AD) share similar clinical features and thus, their diagnosis can be challenging. The aim of this study was to reassess histopathology and immunophenotyping properties to distinguish between ACD, ICD, and AD. Charts of patients with eczema, who had undergone complete routine diagnostic workup (skin biopsies, patch tests, skin prick tests, and respectively or serum IgE levels), were reviewed. Thirty-five skin biopsy specimens of 28 patients (mean age 64 ± 15 years; ♀ = 13 ♂ = 15) with clear diagnosis of A...
Source: The American Journal of Dermatopathology - January 1, 2018 Category: Pathology Tags: Original Study Source Type: research

Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2 –high atopic dermatitis disease endotype
Expression profiling of skin biopsy specimens has established molecular features of the skin in patients with atopic dermatitis (AD). The invasiveness of biopsies has prevented their use in defining individual-level AD pathobiological mechanisms (endotypes) in large research studies.
Source: Journal of Allergy and Clinical Immunology - January 5, 2018 Category: Allergy & Immunology Authors: Nathan Dyjack, Elena Goleva, Cydney Rios, Byung Eui Kim, Lianghua Bin, Patricia Taylor, Caroline Bronchick, Clifton F. Hall, Brittany N. Richers, Max A. Seibold, Donald Y.M. Leung Source Type: research

Presentation and Skin Biopsy Findings in Delayed Type Hypersensitivity Reactions to Facilitated Subcutaneous Immunoglobulin Replacement
Immunoglobulin replacement therapy is an important treatment option for patients with primary immunodeficiency. There are currently multiple immunoglobulin replacement products varying in formulation, route of administration, rate and frequency of administration. Due to these differences, the tolerability of each of these products can vary as well. A better understanding of the adverse reactions associated with individual products would be beneficial for future clinical care.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Kara B. McNamara, Jim M. Fernandez, Lily Pien, Dawn M. Zacharias Source Type: research

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