Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.
Authors: Sciumé GD, Visaggi P, Sostilio A, Tarducci L, Pugno C, Frazzoni M, Ricchiuti A, Bellini M, Giannini EG, Marchi S, Savarino V, De Bortoli N Abstract Eosinophilic esophagitis is a chronic disease whose incidence and prevalence are increasing, based on a genetic-driven interaction between environment and immune system. Several gene loci involved in the development of the disease have been identified. A two-step mechanism has been hypothesized: a TSLP-induced allergic sensitization followed by upregulation of CAPNA14-related esophageal-specific pathways. Environment seems to have a larger effect than ge...
Source: Minerva Gastroenterologica e Dietologica - January 15, 2021 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Hepatic steatosis integrated approach: nutritional guidelines and joined nutraceutical administration.
CONCLUSIONS: Chrysanthellum americanum and Pistacia lentiscus L. extracts were absolutely safe and effective and gave a substantial contribution to the life quality benefit, metabolic balance and gut function in patients with hepatic steatosis. PMID: 33443240 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - January 15, 2021 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Liver and spleen elastography as predictor of portal hypertension and esophageal varices.
Authors: Aquino-Matus J, Uribe M, Chavez-Tapia N Abstract Liver stiffness is related to the degree of hepatic fibrosis which ultimately causes portal hypertension and gastroesophageal varices. Variceal bleeding is a worrisome and potentially fatal complication of cirrhosis, primary prophylaxis has demonstrated a reduction in decompensation and mortality. Portal hypertension and esophageal varices needing treatment could be predicted through noninvasive methods, including elastography, that evaluates the mechanical properties of liver or spleen tissue in concordance to the propagation of mechanical waves. The accura...
Source: Minerva Gastroenterologica e Dietologica - December 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Early detection of pancreatic tumors by advanced EUS imaging.
Authors: Dietrich CF, Shi L, Koch J, Löwe A, Dong Y, Cui XW, Worni M, Jenssen C Abstract The early detection of pancreatic ductal adenocarcinoma (PDAC) dramatically improves outcome. All available state-of-the-art imaging methods allow early detection with EUS being the best technique for exclusion of PDAC and detection of very early PDAC. Etiological differentiation of small SPL is important to guide individually tailored patients management including radical surgery in resectable PDAC, medical (neoadjuvant or palliative intended) treatment in patients with non-resectable malignancy, pancreatic parenchyma sav...
Source: Minerva Gastroenterologica e Dietologica - December 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Risk stratification in primary sclerosing cholangitis.
Authors: Mulinacci G, Cristoferi L, Palermo A, Lucà M, Gerussi A, Invernizzi P, Carbone M Abstract Primary Sclerosing Cholangitis (PSC) is a chronic liver disorder commonly affecting young patients and associated with uncertain prognosis and elevated risk of end-stage liver disease and hepatobiliary cancer. Rate of progression in PSC is heterogeneous and accurately predicting the disease course is of paramount importance to clinical practice and interventional trial design. So far, efforts have brought to the development of models looking at short-to-middle-term outcome using composite models including clini...
Source: Minerva Gastroenterologica e Dietologica - December 12, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Eosinophilic esophagitis and biologics.
Authors: Ghisa M, Laserra G, Maniero D, Marabotto E, Barberio B, Pelizzaro F, Barbuscio I, Zingone F, Savarino V, Savarino E Abstract EoE incidence and prevalence have sharply increased in the last decade and management of these patients is changing rapidly. Standard regimens as elimination diet, proton pump inhibitors and topical swallowed steroids are not able to achieve remission in all patients. Moreover, loss of efficacy and safety concerns for long-term medical treatments are rising questions. As for other chronic immune-mediated diseases, biologics have been evaluated for treatment of EoE. Several targets in...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

The role of endoscopy in eosinophilic esophagitis: from diagnosis to therapy.
Authors: Arsiè E, Cantù P, Penagini R Abstract Endoscopy plays an important role in the management of eosinophilic esophagitis (EoE), since it is involved in the diagnosis, follow up and treatment of this condition. In patients presenting with food impaction, dysphagia and other symptoms of suspected EoE, esophago-gastric-duodenoscopy (EGD) with multiple esophageal biopsies should be performed to confirm or rule out the diagnosis of EoE. The EREFS system, a validated instrument for assessment of the endoscopically-identified esophageal features in EoE (edema, rings, exudates, longitudinal furrows and ...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

What does liver elastography measure? Technical aspects and methodology.
Authors: Dietrich CF, Shi L, Wei Q, Dong Y, Cui XW, Löwe A, Worni M, Ferraioli G Abstract Elastography can be thought as an extension of the ancient technique of palpation. After giving a short introduction to the history of elastography, the different technologies that are nowadays available and the physics behind them, the article focuses on the assessment of liver stiffness in patients with diffuse liver disease using shear wave elastography (SWE). Practical advices on how to perform the SWE techniques and on the factors that should be taken into account for a correct interpretation of the results are given...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

IgG4-related autoimmune liver disease.
Authors: Capurso G, Pedica F, Palumbo D, Della Torre E Abstract The term IgG4-related autoimmune liver disease (AILD) refers to hepato-biliary manifestations of IgG4-related disease (IgG4-RD) including IgG4-related sclerosing cholangitis and IgG4-related pseudotumors. The association of some forms of autoimmune hepatitis to IgG4-RD remains controversial. Although autoimmune phenomena have not been clearly observed in IgG4-AILD, perturbation of the adaptive immune system and activation of the humoral response represent established pathophysiological hallmarks and potential therapeutic targets. Clinical manifestation...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Nutritional approach to eosinophilic esophagitis: which diet and when.
This article updates recent knowledge on dietary therapy for EoE and provides guideline to choose the most suitable alternative for patients with EoE, as well as practical tips to achieve the best results in clinical practice. PMID: 33267566 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Eosinophilic esophagitis: definition, epidemiology and quality of life.
Authors: Frazzoni L, Tolone S Abstract Eosinophilic esophagitis (EoE) is a clinicopathological disease defined by symptoms of esophageal dysfunction and ≥15 eosinophils/HPF after excluding other causes of esophageal eosinophilia. Increasing attention has been paid by clinicians and researchers after its first description in 1978. Many consensuses and guidelines have been issued over the years, as gastroenterologists did not reach an agreement on EoE definition, especially regarding the controversial responsiveness to proton pump inhibitor (PPI) therapy. Of note, recent evidence suggests that the incidence and pr...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Open challenges in the management of autoimmune hepatitis.
Authors: Gerussi A, Halliday N, Carbone M, Invernizzi P, Thorburn D Abstract Autoimmune Hepatitis (AIH) is a rare autoimmune disease of the liver with many open questions as regards its aetiopathogenesis, natural history and clinical management. The classical picture of AIH is chronic hepatitis with fluctuating elevation of serum transaminases and Immunoglobulin G levels, the presence of circulating autoantibodies and typical histological features. However, atypical presentations do occur and are not well captured by current diagnostic scores, with important consequences in terms of missed diagnoses and delayed tre...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

The small intestine: barrier, permeability and microbiota. Key messages for clinicians.
Authors: Stalla FM, Astegiano M, Ribaldone DG, Saracco GM, Pellicano R Abstract In recent years, there has been growing interest in the comprehension of the physiology of intestinal permeability and microbiota and how these elements could influence the pathogenesis of diseases. The term intestinal permeability describes all the processes that allow the passage of molecules as water, electrolytes and nutrients through the intestinal barrier by the para-cellular or the trans-cellular transport systems with several implications for self-tolerance and not-self immunity. An increased permeability might induce a more sig...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Bleeding peptic ulcer disease: over or through the scope clipping?
Authors: Sbeit W, Mari A, Pellicano R, Khoury T PMID: 33267570 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Liver fibrosis in NAFLD patients: examining the opportunity to find a non-invasive, accurate and low-cost tool.
Authors: Sanna C PMID: 33267571 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Safety profile of intravenous iron in inflammatory bowel disease: an up-to-date overview.
Authors: Spagnuolo R, Abenavoli L, Larussa T, Iannelli C, Pellicano R, Fagoonee S, Doldo P, Luzza F Abstract Up to 30-70% of patients may experience mild and moderate side effects during iron therapy and this is often associated with a poor adherence to therapy. Anemia is frequent in patients with active inflammatory bowel disease (IBD), due to both iron deficiency and chronic inflammation, therefore iron supplementation is frequently needed. Considering that gastrointestinal disorders are the most common side effects with oral iron, in IBD patients intravenous administration must be preferred. Although intravenous...
Source: Minerva Gastroenterologica e Dietologica - December 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Current and future perspective on targeted agents and immunotherapies in hepatocellular carcinoma.
Authors: Germani G, Battistella S, Ulinici D, Zanetto A, Shalaby S, Pellone M, Gambato M, Senzolo M, Russo FP, Burra P PMID: 33222429 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

The role of elastography in alcoholic liver disease: fibrosis staging and confounding factors. A review of the current literature.
CONCLUSIONS: We hope that our review article may serve as a reference point in the prospect of futures guidelines. PMID: 33222430 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Hepatocellular carcinoma risk in patients with HBV-related liver disease receiving anti-viral therapy.
Authors: Battistella S, Lynch EN, Gambato M, Zanetto A, Pellone M, Shalaby S, Sciarrone S, Ferrarese A, Germani G, Senzolo M, Burra P, Russo FP Abstract Hepatitis B virus is a major health problem worldwide, with approximatively 240 million people living with a chronic HBV infection. HBV chronic infection remains the major cause of hepatocellular carcinoma worldwide, with more than half of HCC patients being chronic HBV carriers, even if underlying mechanisms of tumourigenesis are not totally understood. HBV-related HCC can be prevented by reducing the exposure to HBV by vaccination or by treatment of CHB infection...
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Drug induced liver injury: from pathogenesis to liver transplantation.
Authors: Germani G, Battistella S, Ulinici D, Zanetto A, Shalaby S, Pellone M, Gambato M, Senzolo M, Russo FP, Burra P Abstract Drug induced liver injury (DILI) is a necro-inflammatory liver disease caused by several drugs commonly used in clinical practice, herbs and dietary supplements prescribed for medical purposes. Despite its rarity, it represents the major cause of acute liver failure requiring liver transplantation in USA and its frequency is increasing in Europe too. Two types of drug induced liver injury have been recognized: intrinsic and idiosyncratic. Predisposing factors may be classified in environme...
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Eosinophilic esophagitis a rising disease.
Authors: de Bortoli N, Savarino EV PMID: 33222433 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Severe acute alcoholic hepatitis: can we offer early liver transplantation?
Authors: Burra P, Bizzaro D, Forza G, Feltrin A, Volpe B, Ronzan A, Feltrin G, Carretta G, D'Amico F, Cillo U, Germani G Abstract Alcohol-related liver disease is one of the most prevalent liver disease worldwide and is the second most common indication for liver transplantation. The majority of transplant programs require 6 months of abstinence prior to transplantation; commonly referred to as the "six-month rule". According to this rule, the patients admitted for severe acute alcoholic hepatitis are not eligible for liver transplantation in most transplant centers. However, there is increasing evidence ...
Source: Minerva Gastroenterologica e Dietologica - November 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Management of portal hypertension severe complications.
Authors: Zanetto A, Barbiero G, Battistel M, Sciarrone SS, Shalaby S, Pellone M, Battistella S, Gambato M, Germani G, Russo FP, Burra P, Senzolo M Abstract Portal hypertension is a clinical syndrome characterized by an increase in the portal pressure gradient, defined as the gradient between the portal vein at the site downstream of the site of obstruction and the inferior vena cava. The most frequent cause of portal hypertension is cirrhosis. In patients with cirrhosis, portal hypertension is the main driver of cirrhosis progression and development of hepatic decompensation (ascites, variceal hemorrhage, and hepat...
Source: Minerva Gastroenterologica e Dietologica - November 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Gastric per-oral endoscopic myotomy for gastroparesis: a spark of hope.
Authors: Khoury T, Sbeit W, Pellicano R, Mari A PMID: 33140624 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - November 5, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Diagnostic accuracy of computerized tomography (CT) angiography in detecting non-variceal gastrointestinal bleeding (NVGIB): a sistematic review.
CONCLUSIONS: CT angiography showed a good sensibility and specificity in detecting NVGIB. Therefore, it would be useful to consider CT angiography use also in the suspicion of NVGIB, especially when endoscopy is not immediately available and there are signs and symptoms of bleeding in progress. PMID: 33103404 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Elastography: where are we now?
Authors: Giuffré M, Colecchia A, Crocé LS PMID: 33103405 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Gastro-esophageal reflux disease: Key messages for clinicians.
Authors: Saracco M, Savarino V, Bodini G, Saracco GM, Pellicano R Abstract Gastroesophageal reflux disease (GERD) is a chronic common disorder for which patients often refer to specialists. In the last decades, numerous studies helped to clarify the pathophysiology and the natural history of this disease. Currently, in the clinical setting, GERD is defined by the presence of symptoms that, when endoscopic investigation is required, permit to distinguish between cases with or without associated esophageal mucosal injuries. These conditions are called erosive reflux disease and non-erosive reflux disease (NERD), resp...
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Irritable Bowel Syndrome and lactose intolerance. A challenging overlap.
Authors: Adriani A, Saracco GM, Pellicano R PMID: 33016665 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 7, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Quercetin Phytosome ® as a potential drug for Covid-19.
Quercetin Phytosome® as a potential drug for Covid-19. Minerva Gastroenterol Dietol. 2020 Oct 05;: Authors: Di Pierro F, Khan A, Bertuccioli A, Maffioli P, Derosa G, Khan S, Khan BA, Nigar R, Ujjan I, Devraian BR Abstract When looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recently identified novel coronavirus (SARS-CoV-2), the knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent 26 RNA polymerase, and spike (S) protein. ...
Source: Minerva Gastroenterologica e Dietologica - October 7, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

The efficacy of fasting regimens on health outcomes: a systematic overview.
CONCLUSIONS: Fasting regimens showed potential beneficial effects on several health indicators in adult populations. Nevertheless, evidence on some specific health dimensions (cognitive function, well-being, quality of life) is limited. Thus, in the future, further RCTs or cohort studies with good methodological quality and larger sample sizes are warranted to better understand the underlying biological mechanism and the benefits on multidimensional aspects of health. PMID: 32914941 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - September 13, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Fatty pancreas and pancreatic cancer: a new player on the field?
Authors: Sbeit W, Mari A, Pellicano R, Khoury T PMID: 32883052 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - September 6, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Probiotics in COVID-19 pandemic: when evidence lacks, rationale can still ease the way.
Authors: Pagnini C, Di Paolo MC, D'alba L, Urgesi R, Pallotta L, Villotti G, D'ambra G, Delle Fave G, Graziani MG PMID: 32883053 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - September 6, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Effectiveness of percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis.
CONCLUSIONS: PEG placement is as an effective, safe nutritional method with a low complication rate in patients with ALS, with or without non-invasive ventilation. The BMI and albumin levels stabilize after PEG placement, indicating benefits of early placement. PMID: 32724029 [PubMed - in process] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 31, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Hypertriglyceridemic pancreatitis.
Authors: De Pretis N, De Marchi G, Frulloni L Abstract Hypertriglyceridemic acute pancreatitis is an emerging issue in gastroenterology, frequently underdiagnosed in clinical practice. Despite the rarity of the disease, hypertriglyceridemia should be considered as a leading cause of acute pancreatitis, especially in defined subsets of patients. Primary and secondary forms of hypertriglyceridemia need to be considered and excluded during the diagnostic work-up of all patients with acute pancreatitis. An accurate diagnosis is crucial to establish an appropriate treatment and to reduce the risk of recurrences. The aim...
Source: Minerva Gastroenterologica e Dietologica - July 31, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Helicobacter pylori and non-alcoholic fatty liver disease.
Authors: Buzás GM Abstract Helicobacter pylori is the most prevalent infection worldwide, while non-alcoholic fatty liver disease emerged as the most frequent liver disease. The common occurrence can be either by chance or due to certain pathogenetic factors. Epidemiologic studies revealed that the risk of non-alcoholic liver disease is increased in patients infected with Helicobacter pylori. DNA fragments of Helicobacter pylori were rarely identified in human samples of liver carcinoma and fatty liver. Helicobacter pylori could influence the development of non-alcoholic fatty liver either by hormonal (ghrel...
Source: Minerva Gastroenterologica e Dietologica - July 31, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Fibromax and inflamatory markers cannot replace liver biopsy in the evaluation of non-alcoholic fatty liver disease.
Authors: Lardi LL, Lul RM, Port GZ, Coral GP, Peres A, Dorneles GP, Branco F, Fernandes S, Leães CG, Mattos AA, Buss C, Tovo CV Abstract BACKGROUND: To evaluate the performance of a non-invasive test (Fibromax™) and inflamatory markers (IL-1 beta, IL-6, IL-8, TNF-alpha, MCP-1) in the diagnosis and staging of patients with non-alcoholic fatty liver disease. METHODS: Patients older than 18 years with steatosis were prospectively evaluated at a tertiary hospital in southern Brazil. Liver biopsy, Fibromax™ test and inflamatory markers (IL 1 beta, IL-6, IL-8, TNF-alpha, MCP-1) were performed. Meas...
Source: Minerva Gastroenterologica e Dietologica - July 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Noninvasive diagnosis of fibrosis in non-alcoholic fatty liver disease: diagnostic accuracy of different scores.
CONCLUSIONS: These findings demonstrated that the most accurate scores, compared to TE, were NFS and FIB 4. PMID: 32700500 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 25, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Impact of E-cadherin and its transcription regulators on assessing epithelial-mesenchymal transition in chronic HCV infection.
CONCLUSIONS: E-cadherin and its transcriptional regulators; snail and slug may serve as indicators for assessing the stage of fibrosis and the progression of HCC associated with HCV infection but not for assessing the degree of hepatitis activity. Therefore, the snail family could be a promising target for designing effective preventive and therapeutic strategies for chronic HCV infection and its serious co-morbidities. PMID: 32677416 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Groove pancreatitis: a case report with a brief review of this diagnostic challenge.
Authors: Valentini G, Surace M, Grosso S, Vernetto A, Serra AM, Andria I, Mazzucco D Abstract Groove Pancreatitis is an uncommon and still under-recognized form of recurrent or chronic pancreatitis that involves the space between the pancreatic head, the duodenum and the common bile duct, the so called groove area. Its importance is that it can mimic pancreatic carcinoma, it may coexist with it or even masks it and should be considered in the differential diagnosis of pancreatic masses or duodenal stenosis. Groove Pancreatitis represents a diagnostic challenge because, from a clinical point of view, its manifestati...
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Ocular manifestations of inflammatory bowel diseases: an update for gastroenterologists.
Authors: Castellano F, Alessio G, Palmisano C Abstract Inflammatory bowel diseases (IBD), that includes ulcerative colitis and Crohn's disease, can affect not only the gastrointestinal tract but a wide spectrum of organs. The extra-intestinal manifestations (EIMs) are one of the most challenging aspect of IBD, playing a significant role for the life-time care and the quality-life of patients. Ocular manifestations are the third most frequent EIMs, preceded by articular and dermatological ones. The aim of this narrative review is to describe the different types of ocular involvements, focusing on their clinical mana...
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Small bowel capsule endoscopy: where do we stand after 20 years of clinical use?
Authors: Pennazio M, Rondonotti E, Pellicano R, Cortegoso Valdivia P Abstract Small bowel capsule endoscopy (SBCE) was introduced into clinical practice almost 20 years ago and, nowadays, it is an essential tool for the study of the small bowel. SBCE allows a radiation-free examination of the entire mucosal surface of the small bowel with high-quality images, limited invasivity and a good safety profile. Nevertheless, the main limitation of SBCE is the lack of any possible direct therapeutic intervention. Indications for SBCE have evolved throughout the years, from "old" ones such as suspected small bowel...
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Elastography for characterization of focal liver lesions: current evidence and future perspectives.
Authors: Martelletti C, Armandi A, Caviglia GP, Saracco GM, Pellicano R Abstract Focal liver lesions (FLLs) are a common finding during routine abdominal ultrasound (US). The differential diagnosis between diverse types of FLLs, especially between benign and malignant ones, is extremely important and can often be particularly challenging. Radiological techniques with contrast administration and/or liver biopsy are mostly necessary for establishing diagnosis, but they have several contraindications or complications. Due to limitations of these tools, there is urgent and still unmet need to develop a first line, non-...
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

COVID-19 and obesity.
Authors: Devecchi A, Ippolito M, Merlo FD, Pira C, Rahimi F PMID: 32677421 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Alcohol related liver disease and Covid-19 emergency: interaction between hepatologist and primary care physician.
Authors: Testino G, Adriani A PMID: 32677422 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 19, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Conservative treatment and radiological follow-up in a case of pneumatosis intestinalis associated with enteral tube feeding.
Authors: Brandi N, Parmeggiani A, Brocchi S, Balacchi C, Gaudiano C, Golfieri R Abstract Pneumatosis Intestinalis (PI) is a rare radiological finding and is defined as the presence of extra- luminal gas within the intestinal wall. PI can be distinguished in a benign form and a life-threatening form, burdened with high mortality. The correct management of PI must always take into account patient's history, his clinical context, laboratory test results and radiological findings, in order to administrate a proper therapy and avoid unnecessary surgical intervention. The pathogenesis of primary PI is still unknown and s...
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Inpatients bowel preparation: with team work we can win.
Authors: Iabichino G, Eusebi LH, Palamara MA, Luigiano C PMID: 32623868 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Rheumatic manifestations in inflammatory bowel disease.
Authors: Finucci A, Ditto MC, Parisi S, Borrelli R, Priora M, Realmuto C, Fusaro E Abstract Rheumatic manifestations are the most frequent extra-intestinal manifestations (EIMs) in Inflammatory Bowel Disease (IBD) patients, and they are responsible for a relevant reduction of quality of life. IBD is associated with a variety of musculoskeletal manifestations such as arthritis and non-inflammatory pain as well as with metabolic diseases, such as osteoporosis. Different imaging techniques (primarily ultrasound, magnetic resonance imaging and X-rays) can help the clinician to correctly identify the nature of manifesta...
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

The relationship between Helicobacter pylori and chronic kidney disease: update 2020.
Authors: Zizzi CF, Pellicano R, Biancone L Abstract A number of studies has confirmed that the epidemiology of Helicobacter pylori (H. pylori) is changing worldwide, with a decrease especially in developed Countries. Nevertheless, since this Gram-negative bacterium infects almost 50% of the world's population, it remains a global problem. Beyond its role in the pathogenesis of the main gastroduodenal diseases, including gastritis, peptic ulcer and gastric cancer, H. pylori has been suspected to be involved in several extra-gastroduodenal disorders. Patients with chronic kidney disease (CKD) present gastric mucosal ...
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Proteins daily distribution and body composition changes in weight-loss.
Authors: Aimasso U, Ippolito M, Pira C, Devecchi A PMID: 32623871 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Management of functional dyspepsia in the year 2020. A clinical point of view.
Authors: Mosso E, Bonetto S, Longobardi G, Abenavoli L, Ribaldone DG, Saracco GM, Pellicano R Abstract Dyspepsia is a disorder that refers mainly to central upper abdominal pain or discomfort. When a cause of this symptom is not identified the condition is termed functional dyspepsia (FD), that affects a large part of the general population. The relevance of FD is due to its high prevalence, but also to its chronic or intermittent course. This induces a significant burden for each national healthcare system. The pathogenesis of FD is complex and multifactorial, depending on cultural, environmental and biological fa...
Source: Minerva Gastroenterologica e Dietologica - July 8, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research