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Nutrition: Vitamins

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Total 289 results found since Jan 2013.

Effects of Ascorbyl-2-phosphate Magnesium on Human Keratinocyte Toxicity and Pathological Changes by Sorafenib.
Abstract Hand-foot skin reaction is recognized as one of the most common adverse events related to multiple tyrosine kinase inhibitors, but an effective prevention method has not been identified. The chief aim of this study was to find a mechanism-based preventive method for the skin toxicity induced by sorafenib using vitamin C derivatives. The effects of ascorbyl-2-phosphate magnesium (P-VC-Mg) on the molecular and pathological changes induced by sorafenib were investigated in human keratinocyte HaCaT cells. The cell growth inhibition and apoptotic effects of sorafenib were attenuated by P-VC-Mg. Moreover, P-VC-...
Source: Biological and Pharmaceutical Bulletin - September 6, 2017 Category: Drugs & Pharmacology Authors: Yamamoto K, Shichiri H, Ishida T, Kaku K, Nishioka T, Kume M, Makimoto H, Nakagawa T, Hirano T, Bito T, Nishigori C, Yano I, Hirai M Tags: Biol Pharm Bull Source Type: research

Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway
Conclusion These results suggest that pyridoxine promotes hippocampal functions by increasing serotonin and tyrosine hydroylase immunoreactivity in the hippocampus. This positive effect may be associated with CRIP1a and CB1 cannabinoid receptor function. General Significance. Vitamin-B6 enhances hippocampal functions and this is closely associated with CRIP1a and CB1 cannabinoid receptors.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - September 19, 2017 Category: Biochemistry Source Type: research

Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts
We assessed the response of primary cultures of placental villous mononucleated trophoblasts and multinucleated syncytiotrophoblast to calcitriol, the most biologically active form of vitamin D. Whole-genome microarray data showed that calcitriol modulates the expression of many genes in trophoblasts within 6 hours of exposure and RT-qPCR revealed similar responses in cytotrophoblasts, syncytiotrophoblasts and villous explants. Both cytotrophoblasts and syncytiotrophoblasts expressed genes for the vitamin D receptor, for LRP2 and CUBN that mediate internalization of calcidiol, for CYP27B1 that encodes the enzyme that conve...
Source: Reproduction - October 31, 2017 Category: Reproduction Medicine Authors: Longtine, M. S., Cvitic, S., Colvin, B. N., Chen, B., Desoye, G., Nelson, D. M. Tags: Research Source Type: research

Rs739837 Polymorphism in MiR-885-3p Binding Site Within 3 ’-Untranslated Region of Vitamin D Receptor is Associated with a Decreased Risk of Pressure Ulcers
Conclusion: VDR is a virtual target of miR-885-3p, and rs739837 might be a predictive biomarker for the risk of pressure ulcers.Cell Physiol Biochem 2017;44:2129 –2137
Source: Cellular Physiology and Biochemistry - December 14, 2017 Category: Cytology Source Type: research

Vitamin A Deficiency Induces Autistic ‐Like Behaviors in Rats by Regulating the RARβ‐CD38‐Oxytocin Axis in the Hypothalamus
Conclusions: Gestational VAD might be a risk factor for autistic‐like behaviors due to the RARβ signal suppression of CD38 expression in the hypothalamus of the offspring, which improved with VAS during the early‐life period. The nutritional status during pregnancy and the early‐life period is important in rats.This article is protected by copyright. All rights reserved
Source: Nahrung / Food - December 21, 2017 Category: Nutrition Authors: Xi Lai, Xiaofeng Wu, Nali Hou, Shu Liu, Qing Li, Ting Yang, Jingkun Miao, Zhifang Dong, Jie Chen, Tingyu Li Tags: Research Article Source Type: research

Sterol regulatory element binding protein 1 trans-activates 25-hydroxy vitamin D3 24-hydroxylase gene expression in renal proximal tubular cells.
Abstract The physiological activity of the steroid derived hormone vitamin D is regulated by several enzymatic steps. Both 25-hydroxy vitamin D3 1α-hydroxylase (CYP27B1) and 25-hydroxyvitamin D3 24-hydroxylase (CYP24A1) modulate blood levels of 1,25-dihydroxyvitamin D3, an activated form of vitamin D. We previously demonstrated that CYP27B1 expression was trans-activated by sterol regulatory element binding protein 1 (SREBP1), although whether SREBP1 also regulates CYP24A1 transcription was unclear. Here we investigated the ability of SREBP1 to affect CYP24A1 transcription. In a luciferase reporter assay, mouse a...
Source: Biochemical and Biophysical Research communications - April 10, 2018 Category: Biochemistry Authors: Kagawa T, Kozai M, Masuda M, Harada N, Nakahashi O, Tajiri M, Yoshikawa R, Nakao M, Takei Y, Iwano M, Takeda E, Taketani Y, Yamamoto H Tags: Biochem Biophys Res Commun Source Type: research

1173 Inducible DNA repair of UV photoproducts depends on vitamin D receptor
Ultraviolet radiation (UV) initiates vitamin D synthesis by converting 7-dehydrocholesterol to pre-vitamin D3 that is converted to 25-hydroxyvitamin D3 (25D3) and then 1,25-dihydroxyvitamin D3 (1,25D3). However, UV also generates DNA damage that is repaired by nucleotide excision repair (NER). We tested the hypothesis that vitamin D signaling elicits compensatory responses to the DNA damage incurred during vitamin D synthesis. Treatment of human keratinocytes with either UVB or with 1,25D3 or 25D3 induced the DNA damage recognition protein, XPC, and induction was suppressed by either siRNA targeting the vitamin D receptor ...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: A. Scandurra, C. Wong, T. Kaur Oberoi, D. Oh Tags: Photobiology Source Type: research

Vitamin D and DDX4 regulate the proliferation and invasion of ovarian cancer cells.
Authors: Chen Y, Sun Z, Xu J, Wang P, Tang J, Shi X, Liu J, Ren F, Xu L Abstract Ovarian cancer is one of the most commonly occurring types of cancer and one of the most common causes of cancer-associated mortality in women. Diagnosis of ovarian cancer at an early stage is difficult due to the lack of specific symptoms. In the present study, it is demonstrated that active vitamin D treatment prohibited the proliferation and invasion of ovarian cancer cells, and the expression level of a germ cell specific marker DEAD (Asp-Glu-Ala-Asp)-box helicase 4 (DDX4), which is overexpressed in ovarian cancer, was downregulate...
Source: Oncology Letters - July 4, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats
This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration. We find that the expressions of TREM-1 and CD68 protein are higher in DN rats compared with rats in the normal control group and that these changes are decreased in the DN + VD group. In vitro, the capacity for macrophage adhesion and migration and the expression of TREM-1 are increased under high-glucose conditions, but VD inhibits this progress....
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research

Role of Mitogen activated-kinase (MAPK)-phosphatase (MKP)-5 in pulmonary fibrosis
Conclusion: Intact MKP5 is required for induction of changes in lung fibroblasts in-vitro and during bleomycin-induced lung fibrosis in-vivo. MKP5 inhibition represent a promising therapeutic target for experimental and lung fibrosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tzouvelekis, A., Karampitsakos, T., Min, K., Xylourgidis, N., Yu, G., Herazo-Maya, J., Bizenhofer, L., Bennett, A., Kaminski, N. Tags: Idiopathic interstitial pneumonias Source Type: research

MKP-5 inhibition blunts fibrotic responses in-vitro and in-vivo through negative regulation of TGFB1-induced smad3-signalling
Conclusion: We conclude that intact MKP5 is required for induction of changes in lung fibroblasts in-vitro and during bleomycin-induced lung fibrosis in-vivo. Our results couple MKP5 activity with TGFB1 signaling machinery identifying MKP5 inhibition as a promising therapeutic strategy for experimental and human lung fibrosis.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Tzouvelekis, A., Xylourgidis, N., Min, K., Karampitsakos, T., Ninou, I., Barbayianni, I., Bennett, A., Aidinis, V., Kaminski, N. Tags: Mechanisms of Lung Injury and Repair Source Type: research

The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions.
Authors: Jonus HC, Hanberry BS, Khatu S, Kim J, Luesch H, Dang LH, Bartlett MG, Zastre JA Abstract Supplemental levels of vitamin B1 (thiamine) have been implicated in tumor progression. Tumor cells adaptively up-regulate thiamine transport during hypoxic stress. Upon uptake, thiamine pyrophosphokinase-1 (TPK1) facilitates the rapid phosphorylation of thiamine into thiamine pyrophosphate (TPP). However, the regulation of TPK1 during hypoxic stress is undefined. Understanding how thiamine homeostasis changes during hypoxia will provide critical insight into the malignant advantage supplemental thiamine may provide c...
Source: Oncotarget - November 22, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Vitamin C Attenuates Sodium Fluoride-Induced Mitochondrial Oxidative Stress and Apoptosis via Sirt1-SOD2 Pathway in F9 Cells.
Abstract Increasing evidence has suggested an important role played by reactive oxygen species (ROS) in the pathogenesis of fluorosis. Accumulating evidence demonstrates that vitamin C administration ameliorate sodium fluoride (NaF)-induced oxidative stress. However, the potentially beneficial effects of vitamin C against NaF-induced cytotoxicity and the underlying molecular mechanisms of this protection are not fully understood. Here, we found that NaF stimulated cytotoxicity, increased mitochondrial reactive oxygen species (mROS) production, and induced apoptosis in F9 embryonic carcinoma cells. Consistent with ...
Source: Biological Trace Element Research - December 18, 2018 Category: Biology Authors: Peng W, Xu S, Zhang J, Zhang Y Tags: Biol Trace Elem Res Source Type: research