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Nutrition: Vitamins
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Total 289 results found since Jan 2013.
Akt/AMPK/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells.
Abstract
Vitamin E succinate (VES), a derivative of vitamin E, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing apoptotic cell death. The effects of VES on autophagy, an intricate programmed process which helps cells survive in some stressed situations by degrading some cytoplasmic material, are unclear. When human gastric cancer cells SCG-7901 were exposed to VES, both the level of microtubule-associated protein 1 light chain 3 and the yeast ATG6 homolog Beclin-1 increased, and related autophagy genes were activated, thereby suggesting that autophagy was induced by VES. We als...
Source: Molecular and Cellular Biochemistry - October 27, 2016 Category: Biochemistry Authors: Yu Y, Hou L, Song H, Xu P, Sun Y, Wu K Tags: Mol Cell Biochem Source Type: research
15-Deoxy- Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.
15-Deoxy-Δ(12,14)-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.
Free Radic Res. 2016 Oct;50(10):1140-1152
Authors: Choi JE, Kim JH, Song NY, Suh J, Kim DH, Kim SJ, Na HK, Nadas J, Dong Z, Cha YN, Surh YJ
Abstract
15-Deoxy-Δ(12,14)-prostaglandin J2 (15d-PGJ2), a representative J-series cyclopentenone prostaglandin, has biphasic roles in cell proliferation and apoptosis. Hypoxia inducible factor-1 (HIF-1) regulates expression of various genes involved in tumor growth and angiogenesis. In the present study...
Source: Free Radical Research - November 6, 2016 Category: Research Tags: Free Radic Res Source Type: research
Maternal 25 ‐hydroxyvitamin D is inversely correlated with fetal serotonin
ConclusionsThese observations provide the first evidence of an inverse relationship between maternal 25(OH)D and fetal serotonin concentrations. We propose that maternal vitamin D deficiency increases fetal serotonin concentrations and thereby contributes to longer‐term neurocognitive impairment in infants and children.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - October 31, 2016 Category: Endocrinology Authors: Padma Murthi, Miranda Davies ‐Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M Wallace, Peter R Ebeling Tags: Original Article Source Type: research
Vitamin D Enhances the Efficacy of Irinotecan through miR-627-Mediated Inhibition of Intratumoral Drug Metabolism
Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression of CYP3A4 are linked to drug resistance. We investigated the function of vitamin D–regulated miR-627 in intratumoral CYP3A4 suppression and its role in enhancing the efficacy of chemotherapy. We found that miR-627 targets CYP3A4 and suppresses CYP3A4 expression in colon cancer cell lines. Furthermore, calcitriol (the active form of vitamin D) suppressed CYP3A4 expression by activating miR-627. As a result, calcitriol inhibited CYP3A4-mediated metabolism of irinotecan (a topoisomerase I inhibitor) in cancer ce...
Source: Molecular Cancer Therapeutics - August 31, 2016 Category: Cancer & Oncology Authors: Sun, M., Zhang, Q., Yang, X., Qian, S. Y., Guo, B. Tags: Small Molecule Therapeutics Source Type: research
Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition
In conclusion, our data demonstrated that GPx4 is an essential antioxidant enzyme for protecting lipid peroxidation, and is a regulator of ferroptosis in vascular endothelial cells. Furthermore, vitamin E rich food, such as brown rice, can compensate for GPx4 loss by protecting cells against lipid peroxidation.
Source: Pathophysiology - November 30, 2016 Category: Pathology Source Type: research
1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells
In conclusion, 1,25-dihydroxy vitamin D3 regulates System A activity through increased mRNA expression of SNAT2 transporters. Effects on placental amino acid transport may be the mechanism underlying the association between maternal vitamin D status and fetal growth.
Source: Molecular and Cellular Endocrinology - December 15, 2016 Category: Endocrinology Source Type: research
Maternal 25 ‐hydroxyvitamin D is inversely correlated with foetal serotonin
ConclusionsThese observations provide the first evidence of an inverse relationship between maternal 25(OH)D and foetal serotonin concentrations. We propose that maternal vitamin D deficiency increases foetal serotonin concentrations and thereby contributes to longer‐term neurocognitive impairment in infants and children.
Source: Clinical Endocrinology - December 18, 2016 Category: Endocrinology Authors: Padma Murthi, Miranda Davies ‐Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M. Wallace, Peter R. Ebeling Tags: Original Article Source Type: research
Calcipotriol inhibits α‐synuclein aggregation in SH‐SY5Y neuroblastoma cells by a Calbindin‐D28K‐dependent mechanism
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - February 5, 2017 Category: Neuroscience Authors: Alexandre N. Rcom ‐H'cheo‐Gauthier, Adrian C. B. Meedeniya, Dean L. Pountney Tags: Original Article Source Type: research
Experimental Study on 1,25(OH)2D3 Amelioration of Oral Lichen Planus through Regulating NF ‐κB Signaling Pathway
ConclusionThese results suggest that 1,25(OH)2D3 plays an anti‐inflammatory role in OLP by mediating NF‐κB signaling pathway but not AP‐1 signaling pathway with a VDR‐dependent manner, predicting vitamin D supplement may be a potential strategy for the OLP management.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - February 22, 2017 Category: ENT & OMF Authors: Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang Tags: Original Article Source Type: research
Autocrine and Paracrine Interactions between Multiple Myeloma Cells and Bone Marrow Stromal Cells by Growth Arrest-specific Gene 6 Cross-talk with Interleukin-6 Signal Transduction
The pathogenesis of multiple myeloma (MM) has not yet been fully elucidated. Our microarray analysis and immunohistochemistry revealed significant up-regulation of growth arrest-specific gene 6 (Gas6), a vitamin K-dependent protein with a structural homology with protein S, in bone marrow (BM) cells of MM patients. ELISA showed that the serum levels of soluble Gas6 were significantly increased in the MM patients when compared with healthy controls. Gas6 was overexpressed in the human CD138-positive MM cell line RPMI-8226. Exogenous Gas6 suppressed apoptosis induced by serum deprivation and enhanced cell proliferation of th...
Source: Journal of Biological Chemistry - March 9, 2017 Category: Chemistry Authors: Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeishi Tags: Cell Biology Source Type: research
MAPK Signaling has Stage-dependent Osteogenic Effects on Human Adipose-derived Stem Cells in vitro.
CONCLUSIONS: It is likely that MAPK signaling plays a significant role in ASC osteogenesis, affecting differentiation in kinase- and stage-specific manners.
PMID: 28398098 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - April 13, 2017 Category: Research Tags: Connect Tissue Res Source Type: research
1,25-Dihydroxyvitamin D3 suppresses gastric cancer cell growth through VDR- and mutant p53-mediated induction of p21
Publication date: Available online 29 April 2017 Source:Life Sciences Author(s): Mingxing Li, Longfei Li, Lin Zhang, Wei Hu, Jing Shen, Zhangang Xiao, Xu Wu, Franky Leung Chan, Chi Hin Cho Aims Previous studies have indicated that vitamin D deficiency correlates with cancer risk and vitamin D potentiates antitumor effects in a variety of cancers. The antitumor effect of vitamin D on gastric cancer was rarely studied. We aimed to investigate the antitumor effect of vitamin D on gastric cancer and underlying mechanisms. Main methods We investigated the antitumor activity of the active form of vitamin D, 1α,25-dihydroxyvita...
Source: Life Sciences - April 30, 2017 Category: Biology Source Type: research
Calcitriol-mediated reduction in IFN- γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation
Publication date: Available online 20 July 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): M. Paige Kulling, C. Kristine Olson, L. Thomas Olson, E. Cait Hamele, N. Kathryn Carter, J. David Feith, P. Thomas Loughran Constitutively activated STAT1 and elevated IFN-γ are both characteristic of T cell large granular lymphocytic leukemia (T-LGLL), a rare incurable leukemia with clonal expansion of cytotoxic T cells due to defective apoptosis. Interferon gamma (IFN-γ) is an inflammatory cytokine that correlates with worse progression and symptomology in multiple autoimmune diseases and cancers...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 21, 2017 Category: Biochemistry Source Type: research
Advances in nanomicelles for sustained drug delivery
Publication date: 25 November 2017 Source:Journal of Industrial and Engineering Chemistry, Volume 55 Author(s): Najmeh Amirmahani, Nosrat O. Mahmoodi, Mohsen Mohammadi Galangash, Atefeh Ghavidast The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions. Over the past decades, polymeric micelles are interesting nanocarries for drug delivery systems due to small size (10–100nm), low toxicity, capacity to solubilize lipophilic drugs in core and high drug loading. Here, the design of various nanomicelles such as amphiphilic dendrimer,...
Source: Journal of Industrial and Engineering Chemistry - August 5, 2017 Category: Chemistry Source Type: research
A new combination therapy for asthma using dual function dexamethsone-conjugated polyethylenimine and vitamin D binding protein siRNA
Gene Therapy, Published online: 28 August 2017; doi:10.1038/gt.2017.83
Source: Gene Therapy - August 28, 2017 Category: Genetics & Stem Cells Authors: M Choi J Gu M Lee T Rhim Source Type: research
