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Total 124 results found since Jan 2013.

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Prenatal Exposure to Mercury: Associations with Global DNA Methylation and Hydroxymethylation in Cord Blood and in Childhood
Conclusions: Prenatal mercury exposure was associated with lower %-5hmC genomic content and a corresponding increase in the ratio of %-5mC to %-5hmC in cord blood. This association was persistent in early but not midchildhood blood. Our results demonstrate the potential malleability of epigenetic modifications associated with mercury exposure in utero. https://doi.org/10.1289/EHP1467 Received: 06 December 2016 Revised: 04 May 2017 Accepted: 19 May 2017 Published: 29 August 2017 Address correspondence to A. Cardenas, Dept. of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 401 Pa...
Source: EHP Research - August 29, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Network Medicine in the Age of Biomedical Big Data
Conclusion and Future Directions Above we reviewed a limited set of network medicine philosophies that seek to integrate biomedical big data to uncover meaningful biology. Network medicine approaches provide customized and optimized ways to leverage biomedical data. The choice of the appropriate network method is largely dictated by the underlying biological inquiry, hypotheses, study design, and available data. Although this review is not meant to be exhaustive, our intent was to give a essence of how biomedical data requires a nuanced approach when selecting network analyses and provide a resource for both network scien...
Source: Frontiers in Genetics - April 10, 2019 Category: Genetics & Stem Cells Source Type: research

To Embed or Not: Network Embedding as a Paradigm in Computational Biology
Conclusion We have reviewed several classes of approaches for network embedding, including spectral-based methods, random-walk based approaches and deep neural network techniques. We have demonstrated the utility of these approaches in a broad set of applications, ranging from network alignment to community detection, protein function prediction, and network denoising. We have also discussed recent embedding approaches in pharmacogenomics. We were interested in seeing whether the field of network embedding indeed enhances the types of questions that can be answered using graph-based approaches and our conclusion is that t...
Source: Frontiers in Genetics - April 30, 2019 Category: Genetics & Stem Cells Source Type: research

RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection
In conclusion, the transcriptome analyses reported here present a unique and detailed genetic profile of zebrafish larval immune cells, thereby providing a valuable resource that can be data mined to verify the expression of specific genes in the profiled cell types or to identify novel genes of interest and potential cell-specific markers. In future work single cell RNA sequencing technology will be useful to interrogate the heterogeneity in expression profiles of resting and activated macrophages. Ethics Statement This study was carried out in accordance with the local animal welfare regulations as overseen by the Anim...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation
Conclusion It was showed that e-As4S4 could alleviate the metastatic features of aggressive breast cancers through correcting the tumor microenvironment, which prolonged the survival of tumor-bearing mice, showing its important therapeutic implications to the anti-metastasis therapy for breast cancer. Ethics Statement Six-week-old, female BALB/c mice were bred at the Experimental Animal Center at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (Beijing, China) under specific pathogen-free conditions. All the animal experiments reported herein were carried out in compliance with the regulatio...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

Markers of Pulmonary Oxygen Toxicity in Hyperbaric Oxygen Therapy Using Exhaled Breath Analysis
Conclusion In this study, after daily HBOT for 6 days, we identified 11 VOCs which could be divided into two PCs. PC1 (inflammation) showed no significant changes over time, PC2 (methyl alkanes) was significantly reduced after daily exposure for 5 days, to approximately 60% after 2 days’ rest. This suggests that daily HBOT does not induce cumulative damage to the pulmonary system of healthy volunteers, but triggers an adaptive response. Additional studies including more treatment sessions, and perhaps additional systemic parameters on radical oxygen scavengers and inflammatory markers, are necessary to substantiate...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

The Saliva Exposome for Monitoring of Individuals ’ Health Trajectories
Conclusions: Saliva contains molecular information worthy of interrogation via EWAS. The simplicity of specimen collection suggests that saliva offers a practical alternative to blood for measurements that can be used to characterize individual exposomes. https://doi.org/10.1289/EHP1011 Received: 23 August 2016 Revised: 08 November 2016 Accepted: 18 November 2016 Published: 20 July 2017 Address correspondence to V. Bessonneau, Silent Spring Institute, 320 Nevada St., Suite 302, Newton, Massachusetts 02460 USA. Telephone: (617) 332-4288. Email: vincent.bessonneau@gmail.com The authors declare they have no actual or po...
Source: EHP Research - July 20, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Source Type: research

Mineralized alginate hydrogels using marine carbonates for bone tissue engineering applications
Publication date: 1 September 2018 Source:Carbohydrate Polymers, Volume 195 Author(s): P. Diaz-Rodriguez, P. Garcia-Triñanes, M.M. Echezarreta López, A. Santoveña, M. Landin The search for an ideal bone tissue replacement has led to the development of new composite materials designed to simulate the complex inorganic/organic structure of bone. The present work is focused on the development of mineralized calcium alginate hydrogels by the addition of marine derived calcium carbonate biomineral particles. Following a novel approach, we were able to obtain calcium carbonate particles of high purity and complex micro and n...
Source: Carbohydrate Polymers - May 2, 2018 Category: Biomedical Science Source Type: research

Adverse reactions on day zero of hematopoietic stem cell transplantation: integrative review.
CONCLUSION: The main adverse reactions identified in the studies were nausea and emesis. Those classified as mild and moderate were the most frequent in the studies that used the severity classification; and the cardiovascular, respiratory and gastrointestinal systems were the most affected in those that used the classification by organic systems. PMID: 30517435 [PubMed - in process]
Source: Revista gaucha de enfermagem EENFUFRGS - December 7, 2018 Category: Nursing Tags: Rev Gaucha Enferm Source Type: research

A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression
Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Bone regeneration as an example of tissue engineering in dentistry, with an emphasis on the development of scaffolds
Conclusiones: Los andamios son los que brindan mayor oferta para su uso y la elección de cada uno de ellos no depende del material en sí mismo.Resumo: A engenharia de tecidos é uma área científica multidisciplinar cujo objetivo é restaurar, substituir e aumentar as atividades funcionais dos tecidos orgânicos. Objetivos: O objetivo deste trabalho é revisar a literatura sobre engenharia de tecidos no nível da área bucomaxilofacial. Métodos: Foi realizada uma p esquisa bibliográfica no portals PubMed MEDLINE, Google Scholar, e LILACS, utilizando os termos “ c élulas-tronco, regeneração óssea e fatores de cre...
Source: Odontoestomatologia - December 4, 2020 Category: Dentistry Source Type: research

Janssen Highlights Commitment to Advancing Transformative Innovations in Oncology with Scientific Updates from Deep, Diverse Pipeline and Portfolio at ASCO and EHA Virtual Scientific Programs
June 1, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 30 company-sponsored studies, including six oral presentations, will be featured during the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, June 4-8. Janssen presentations will include new data and updates for both approved and investigational therapeutics that are being studied for the treatment of various solid tumors and blood cancers. Immediately following ASCO, additional data will be featured during the European Hematology Association (EHA) Virtual Congress, June 9-17. A comp...
Source: Johnson and Johnson - June 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression
Exp Mol Med. 2023 Aug 1. doi: 10.1038/s12276-023-01059-0. Online ahead of print.ABSTRACTImproving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that plays an important role in regulating cell biological functions, and ALKBH5 is one of the key m6A demethylases. However, the role of m6A and ALKBH5 in MSC senescence is still unclear. Here, we found that the m6A level was enhanced and ALKBH5 expressio...
Source: Molecular Medicine - July 31, 2023 Category: Molecular Biology Authors: Guiwen Ye Jinteng Li Wenhui Yu Zhongyu Xie Guan Zheng Wenjie Liu Shan Wang Qian Cao Jiajie Lin Zepeng Su Dateng Li Yunshu Che Shuai Fan Peng Wang Yanfeng Wu Huiyong Shen Source Type: research

Effects of Inorganic Arsenic, Methylated Arsenicals, and Arsenobetaine on Atherosclerosis in the apoE-/- Mouse Model and the Role of As3mt-Mediated Methylation
Conclusion: Taken together, our findings indicate that As3MT acts to promote cardiovascular toxicity of arsenic and suggest that human AS3MT SNPs that correlate with enzyme function could predict those most at risk to develop atherosclerosis among the millions that are exposed to arsenic. https://doi.org/10.1289/EHP806 Received: 15 July 2016 Revised: 21 December 2016 Accepted: 21 December 2016 Published: 05 July 2017 Correspondence: K.K. Mann, Lady Davis Institute for Medical Research, McGill University, 3755 Cote Ste Catherine Rd., Montreal, QC, H3T 1E2 Canada; Telephone: (514) 340-8222 ext. 2760; Email: koren.mann@...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research